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Different effects of the immunostimulatory drug Stimforte on infections of hepatitis C virus and herpes simplex virus type 1

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Abstract

Stimforte, an immune response-stimulating preparation, is active with respect to hepatitis C virus (HCV) and herpes simplex virus type I (HSV-1). The effects of Stimforte in animals infected with either HCV or HSV-1 are fundamentally different. In mice with acute herpes virus infection, Stimforte administration leads to a higher activity of natural killer cells and cytotoxic lymphocytes, and the amount of interferon (IFN) λ grows. In mice infected with HCV, Stimforte administration results in a significant increase in IFN-β but not IFN-λ in blood and affected organs. Stimforte has been found to affect directly HCV reproduction that causes the infected cell death, but it does not affect HSV-1 reproduction in the Vero cells (V).

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References

  1. Tsalenchuck, Y., Steiner, I., and Panet, A., J. Neurovirol., 2016, vol. 22, no. 5, pp. 641–649.

    Article  CAS  PubMed  Google Scholar 

  2. Maldov, D.G., Grigoryan, S.S., Galegov, G.A., et al., Immunologiya, 2011, no. 5, pp. 250–256.

    Google Scholar 

  3. Maldov, D.G., Lebedinskaya, O.V., Chetvertnykh, V.A., et al., Med. Immunol., 2011, no. 2, pp. 133–138.

    Google Scholar 

  4. Maldov, D.G., Chirvon, E.A., Il’ichev, A.V., et al., Immunologiya, 2011, vol. 5, pp. 105–112.

    Google Scholar 

  5. Chew, T., Taylor, K.E., and Mossman, K.L., Viruses, 2009, vol. 1, pp. 979–1002.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Sun, J., Rajsbaum, R., and Yi, M., World J. Gastroenterol., 2015, vol. 21, no. 38, pp. 10739–10748.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Deryabin, P.G., Isaeva, E.I., Maldov, D.G., et al., Vopr. Virusol., 2009, no. 2, pp. 17–20.

    Google Scholar 

  8. Maldov, D.G., Andronova, V.L., Balakina, A.A., et al., Vopr. Virusol., 2016, no. 4, pp. 30–33.

    Google Scholar 

  9. Melroe, G.T., Silva, L., Schaffer, P.A., et al., Virology, 2007, vol. 360, no. 2, pp. 305–321.

    Article  CAS  PubMed  Google Scholar 

  10. Ank, N., West, H., Bartholdy, C., et al., J. Virol., 2006, vol. 80, pp. 4501–4509.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Pagliaccetti, N.E. and Robek, M.D., J. Int. Cytok. Res., 2010, vol. 30, no. 8, pp. 585–590.

    Article  CAS  Google Scholar 

  12. Thomas, E., Gonzalez, V.D., Li, Q., et al., Gastroenterology, 2012, vol. 142, no. 4, pp. 978–988.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Wang, S.H., Huang, C.X., Ye, L., et al, J. Viral. Hepat., 2008, vol. 15, no. 12, pp. 855–864.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Tatsumi, T. and Takehara, T., Hepatol. Res., 2016, vol. 46, no. 5, pp. 416–422.

    Article  CAS  PubMed  Google Scholar 

  15. Spaan, M., van Oord, G., Kreefft, K., et al., J. Infect. Dis., 2016, vol. 213, no. 2, pp. 216–223.

    Article  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. ZAO SKY LTD, Moscow, Russia

    D. G. Maldov & A. V. Ilyichev

  2. Gamaleya Institute of Epidemiology and Microbiology, Ministry of Health, Moscow, Russia

    V. L. Andronova, S. S. Grigorian, E. I. Isaeva, P. G. Deryabin, D. V. Mishin & G. A. Galegov

  3. Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow oblast, Russia

    A. A. Balakina & A. A. Terentyev

Authors
  1. D. G. Maldov
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  2. V. L. Andronova
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  3. S. S. Grigorian
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  4. E. I. Isaeva
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  5. P. G. Deryabin
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  6. D. V. Mishin
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  7. A. A. Balakina
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  8. A. V. Ilyichev
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  9. A. A. Terentyev
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  10. G. A. Galegov
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Corresponding author

Correspondence to D. G. Maldov.

Additional information

Presented by academician F.I. Ershov April 4, 2017

Original Russian Text © D.G. Maldov, V.L. Andronova, S.S. Grigorian, E.I. Isaeva, P.G. Deryabin, D.V. Mishin, A.A. Balakina, A.V. Ilyichev, A.A. Terentyev, G.A. Galegov, 2017, published in Doklady Akademii Nauk, 2017, Vol. 477, No. 2, pp. 257–260.

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Maldov, D.G., Andronova, V.L., Grigorian, S.S. et al. Different effects of the immunostimulatory drug Stimforte on infections of hepatitis C virus and herpes simplex virus type 1. Dokl Biol Sci 477, 219–222 (2017). https://doi.org/10.1134/S0012496617060035

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  • DOI: https://doi.org/10.1134/S0012496617060035

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