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Localization of the dopamine receptors of types 1 and 2 on the bodies of POMC-expressing neurons of the arcuate nucleus of the hypothalamus in mice and rats

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Abstract

Using immunofluorescent techniques, we have demonstrated the presence of two main types of dopamine receptors, D1 and D2, on the bodies of neurons of the arcuate nucleus of the hypothalamus expressing the precursor of peptides of the melanocortin family proopiomelanocortin in C57Bl/6J mice and Wistar rats. These data show close functional relationship between the dopamine and melanocortin systems of the brain and involvement of dopamine in the control of synthesis and secretion of peptides of the melanocortin family.

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Authors and Affiliations

  1. Sechenov Institute of Evolutionary Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia

    I. V. Romanova, A. L. Mikhrina & A. O. Shpakov

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  1. I. V. Romanova
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  2. A. L. Mikhrina
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  3. A. O. Shpakov
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Correspondence to I. V. Romanova.

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Original Russian Text © I.V. Romanova, A.L. Mikhrina, A.O. Shpakov, 2017, published in Doklady Akademii Nauk, 2017, Vol. 472, No. 5, pp. 608–611.

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Romanova, I.V., Mikhrina, A.L. & Shpakov, A.O. Localization of the dopamine receptors of types 1 and 2 on the bodies of POMC-expressing neurons of the arcuate nucleus of the hypothalamus in mice and rats. Dokl Biol Sci 472, 11–14 (2017). https://doi.org/10.1134/S0012496617010082

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  • DOI: https://doi.org/10.1134/S0012496617010082

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