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Chirality As a Symmetric Basis of Self-Organization of Biomacromolecules

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Abstract

A review of materials within the concept of chirality as a symmetric basis of self-organization in biomacromolecules is presented. The following topics are considered: methods for determining the chirality of regular and irregular protein structures, the distribution of helical and superhelical structures in polypeptide chains, a model for the formation of a three-dimensional structure of the right-handed α-helix from a chain of L-amino acid residues, and a model for the formation of the right-handed α-helix based on a two-particle model of movement in the Lennard-Jones potential. The applied aspects of the concept of chirality in pharmacology and bioengineering, the chirality of drugs with bioactive enantiomers and the mechanisms of self-assembly of helical structures of phenylalanine and diphenylalanine nanotubes of different chirality are discussed. The basic concepts of molecular machines as chiral hierarchical structures are presented.

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Funding

The research was carried out with the financial support of the Foundation for the Development of Theoretical Physics and Mathematics “BASIS” within projects no. 21-2-9-42-1 (to E.V. Semenova) and no. 21-2-1-14-1 (to O.E. Bagrova), as well as the Interdisciplinary Scientific and Educational School of Lomonosov Moscow State University “Fundamental and Applied Space Research”.

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  1. Faculty of Physics, Lomonosov Moscow State University, 119991, Moscow, Russia

    V. A. Tverdislov, A. E. Sidorova, O. E. Bagrova, E. V. Belova, N. T. Levashova, A. O. Lutsenko, E. V. Semenova & D. K. Shpigun

  2. Institute of Mathematical Problems of Biology, 142290, Pushchino, Moscow oblast, Russia

    V. S. Bystrov

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  1. V. A. Tverdislov
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  2. A. E. Sidorova
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  4. E. V. Belova
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  5. V. S. Bystrov
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  6. N. T. Levashova
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  7. A. O. Lutsenko
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Correspondence to A. E. Sidorova.

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Translated by E. Puchkov

Abbreviations: PDB, Protein Data Bank; PNT, peptide nanotube.

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Tverdislov, V.A., Sidorova, A.E., Bagrova, O.E. et al. Chirality As a Symmetric Basis of Self-Organization of Biomacromolecules. BIOPHYSICS 67, 673–691 (2022). https://doi.org/10.1134/S0006350922050190

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