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Gold Nanoparticles as Potential Radiosensitizing and Cytotoxic Agents

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Abstract—This review summarizes the data on the radiosensitizing properties and cytotoxic activity of gold nanoparticles obtained in studies of experimental tumor models. Plausible mechanisms that underlie the observed effects are considered.

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Authors and Affiliations

  1. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334, Moscow, Russia

    D. B. Korman, L. A. Ostrovskaya, N. V. Bluhterova, V. A. Rykova & M. M. Fomina

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  1. D. B. Korman
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  2. L. A. Ostrovskaya
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  3. N. V. Bluhterova
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  4. V. A. Rykova
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Correspondence to D. B. Korman.

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Translated by V. Gulevich

Abbreviations: GNs, gold nanoparticles; BC, breast carcinoma; CC, colorectal cancer; PC, prostate cancer; HNSCC, head and neck squamous cell carcinoma; EPR, enhanced permeability and retention; DIF, dose increase factor; ROS, reactive oxygen species; EGFR, epidermal growth factor receptor; PGNs, pegylated gold nanoparticles.

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Korman, D.B., Ostrovskaya, L.A., Bluhterova, N.V. et al. Gold Nanoparticles as Potential Radiosensitizing and Cytotoxic Agents. BIOPHYSICS 66, 1046–1058 (2021). https://doi.org/10.1134/S0006350921060063

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