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Role of YB-1 Protein in Inflammation

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Abstract

This review discusses the role of the multifunctional DNA/RNA-binding protein YB-1 in inflammation. YB-1 performs multiple functions in the cell depending on its location: it acts as transcriptional factor for many genes in the nucleus, regulates translation and stability of mRNA in the cytoplasm, and becomes a paracrine factor when secreted from the cells. The review presents the data on the YB-1-mediated regulation of inflammation-associated genes, as well as results of studies on the YB-1 role in animal model of various inflammatory diseases, such as glomerulonephritis, tubulointerstitial fibrosis, and bacterial sepsis, and on the YB-1 expression in different human diseases associated with inflammatory processes in kidney, liver, and endometrium. The last section of the review presents several approaches to the regulation of YB-1 with small molecules in the treatment of inflammatory diseases.

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Abbreviations

GM-CSF:

granulocyte-macrophage colony-stimlating factor

IL:

interleukin

LPS:

lipopolysaccharide

PDGF-B:

platelet-derived growth factor B

YB-1:

Y-box binding protein 1

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  1. Blokhin National Research Center of Oncology, Ministry of Health of the Russian Federation, 115478, Moscow, Russia

    Ekaterina Yu. Rybalkina & Natalia I. Moiseeva

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  1. Ekaterina Yu. Rybalkina
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  2. Natalia I. Moiseeva
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Correspondence to Natalia I. Moiseeva.

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The authors declare no conflicts of interest in financial or any other sphere. This article does not contain any studies with human participants or animals performed by any of the authors.

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Translated from Uspekhi Biologicheskoi Khimii, 2022, Vol. 62, pp. 205-224.

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Rybalkina, E.Y., Moiseeva, N.I. Role of YB-1 Protein in Inflammation. Biochemistry Moscow 87 (Suppl 1), S94–S102 (2022). https://doi.org/10.1134/S0006297922140085

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