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SkQ1 as a Tool for Controlling Accelerated Senescence Program: Experiments with OXYS Rats

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Abstract

According to the concept suggested by V. P. Skulachev and co-authors, aging of living organisms can be considered as a special case of programmed death of an organism – phenoptosis, and mitochondrial antioxidant SkQ1 is capable of inhibiting both acute and chronic phenoptosis (aging). The authors of the concept associate effects of SkQ1 with suppression of the enhanced generation of ROS in mitochondria. Numerous studies have confirmed the ability of SkQ1 to inhibit manifestations of the “healthy”, or physiological, aging. According to the results of our studies, SkQ1 is especially effective in suppressing the program of genetically determined accelerated senescence in OXYS rats, which appears as an early development of a complex of age-related diseases: cataracts, retinopathy (similar to the age-related macular degeneration in humans), osteoporosis, and signs of Alzheimer’s disease. Accelerated senescence in OXYS rats is associated with mitochondrial dysfunction, but no direct associations with oxidative stress have been identified. Nevertheless, SkQ1 is able to prevent and/or suppress development of all manifestations of accelerated senescence in OXYS rats. Its effects are due to impact on the activity of many signaling pathways and processes, but first of all they are associated with restoration of the structural and functional parameters of mitochondria. It could be suggested that the use of SkQ1 could represent a promising strategy in prevention of accelerated phenoptosis – early development of a complex of age-related diseases (multimorbidity) in people predisposed to it.

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Abbreviations

Aβ:

amyloid beta

AD:

Alzheimer disease

AMD:

age-related macular degeneration

GH:

growth hormone

MAPK:

mitogen-activated protein kinases

ROS:

reactive oxygen species

SkQ1:

plastoquinonyl decyl triphenylphosphonium

VEGF:

vascular endothelial growth factor

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Funding

This study was financially supported by the State Budget project FWNR-2022-0016.

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Authors and Affiliations

  1. Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 630090, Novosibirsk, Russia

    Nataliya G. Kolosova, Oyuna S. Kozhevnikova, Natalia A. Muraleva, Ekaterina A. Rudnitskaya, Yuliya V. Rumyantseva, Natalia A. Stefanova, Darya V. Telegina, Mikhail A. Tyumentsev & Anzhella Zh. Fursova

  2. Novosibirsk State Medical University, 630091, Novosibirsk, Russia

    Anzhella Zh. Fursova

Authors
  1. Nataliya G. Kolosova
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  2. Oyuna S. Kozhevnikova
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  3. Natalia A. Muraleva
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  4. Ekaterina A. Rudnitskaya
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  5. Yuliya V. Rumyantseva
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  6. Natalia A. Stefanova
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  7. Darya V. Telegina
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  8. Mikhail A. Tyumentsev
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  9. Anzhella Zh. Fursova
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Contributions

N. G. Kolosova – concept of the study, supervision of work, preparation of the review; all other authors – equal contribution to investigation of the processes of accelerated aging in OXYS rats and effects of SkQ1 on them.

Corresponding author

Correspondence to Nataliya G. Kolosova.

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The authors declare no conflict of interest in financial or any other sphere. This article does not contain any studies with human participants or animals performed by any of the authors.

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Kolosova, N.G., Kozhevnikova, O.S., Muraleva, N.A. et al. SkQ1 as a Tool for Controlling Accelerated Senescence Program: Experiments with OXYS Rats. Biochemistry Moscow 87, 1552–1562 (2022). https://doi.org/10.1134/S0006297922120124

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  • DOI: https://doi.org/10.1134/S0006297922120124

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