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Iron-sulfur clusters in mitochondrial metabolism: Multifaceted roles of a simple cofactor

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Abstract

Iron-sulfur metabolism is essential for cellular function and is a key process in mitochondria. In this review, we focus on the structure and assembly of mitochondrial iron-sulfur clusters and their roles in various metabolic processes that occur in mitochondria. Iron-sulfur clusters are crucial in mitochondrial respiration, in which they are required for the assembly, stability, and function of respiratory complexes I, II, and III. They also serve important functions in the citric acid cycle, DNA metabolism, and apoptosis. Whereas the identification of iron-sulfur containing proteins and their roles in numerous aspects of cellular function has been a long-standing research area, that in mitochondria is comparatively recent, and it is likely that their roles within mitochondria have been only partially revealed. We review the status of the field and provide examples of other cellular iron-sulfur proteins to highlight their multifarious roles.

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Abbreviations

BN-PAGE:

blue native polyacrylamide gel electrophoresis

cI-III:

respiratory complexes I-III

CIA:

cytosolic iron-sulfur protein assembly

ETC:

electron transport chain

Fe-S:

iron-sulfur

IRE:

iron-responsive elements

IRP:

ironregulatory protein

ISCs:

iron-sulfur clusters

ISP:

iron-sulfur protein

mtDNA:

mitochondrial DNA

Q:

ubiquinone

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Authors and Affiliations

  1. Department of Biology and Biochemistry, Birzeit University, P.O. Box 14, West Bank 627, Birzeit, Palestine

    Johnny Stiban

  2. Department of Biochemistry and Molecular Biology and Center for Mitochondrial Science and Medicine, Michigan State University, East Lansing, 48824, Michigan, USA

    Minyoung So & Laurie S. Kaguni

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  1. Johnny Stiban
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  2. Minyoung So
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Published in Russian in Biokhimiya, 2016, Vol. 81, No. 10, pp. 1332–1348.

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Stiban, J., So, M. & Kaguni, L.S. Iron-sulfur clusters in mitochondrial metabolism: Multifaceted roles of a simple cofactor. Biochemistry Moscow 81, 1066–1080 (2016). https://doi.org/10.1134/S0006297916100059

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