Skip to main content
SpringerLink
Log in

Nucleotide excision repair: DNA damage recognition and preincision complex assembly

  • Review
  • Published:
Biochemistry (Moscow) Aims and scope Submit manuscript

Abstract

Nucleotide excision repair (NER) is one of the major DNA repair pathways in eukaryotic cells counteracting genetic changes caused by DNA damage. NER removes a wide set of structurally diverse lesions such as pyrimidine dimers arising upon UV irradiation and bulky chemical adducts arising upon exposure to carcinogens or chemotherapeutic drugs. NER defects lead to severe diseases including some forms of cancer. In view of the broad substrate specificity of NER, it is of interest to understand how a certain set of proteins recognizes various DNA lesions in the context of a large excess of intact DNA. This review focuses on DNA damage recognition and following stages resulting in preincision complex assembly, the key and still most unclear steps of NER. The major models of primary damage recognition and preincision complex assembly are considered. The contribution of affinity labeling techniques in study of this process is discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

a.a.:

amino acid residue

Cen2:

protein centrin-2

NER:

nucleotide excision repair

nt:

nucleotide residue

RPA:

replication protein A

XP:

xeroderma pigmentosum

References

  1. Lindahl, T., and Wood, R. D. (1999) Science, 286, 1897–1905.

    Article  CAS  PubMed  Google Scholar 

  2. Hoeijmakers, J. H. (2001) Nature, 411, 366–374.

    Article  CAS  PubMed  Google Scholar 

  3. Scharer, O. D. (2003) Angew. Chem. Int. Ed. Engl., 42, 2946–2974.

    Article  PubMed  Google Scholar 

  4. Sancar, A., Lindsey-Boltz, L. A., Unsal-Kacmaz, K., and Linn, S. (2004) Annu. Rev. Biochem., 73, 39–85.

    Article  CAS  PubMed  Google Scholar 

  5. Wood, R. D., Mitchell, M., Sgouros, J., and Lindahl, T. (2001) Science, 291, 1284–1289.

    Article  CAS  PubMed  Google Scholar 

  6. Gillet, L. C., and Scharer, O. D. (2006) Chem. Rev., 106, 253–276.

    Article  CAS  PubMed  Google Scholar 

  7. Sweder, K. S., and Hanawalt, P. C. (1993) Science, 262, 439–440.

    Article  CAS  PubMed  Google Scholar 

  8. Aboussekhra, A., Biggerstaff, M., Shivji, M. K., Vilpo, J. A., Moncollin, V., Podust, V. N., Protic, M., Hubscher, U., Egly, J. M., and Wood, R. D. (1995) Cell, 80, 859–681.

    Article  CAS  PubMed  Google Scholar 

  9. Mu, D., Park, C. H., Matsunaga, T. D., Hsu, S. J., Reardon, T., and Sancar, A. (1995) J. Biol. Chem., 270, 2415–2418.

    Article  CAS  PubMed  Google Scholar 

  10. Araujo, S. J., Tirode, F., Coin, F., Pospiech, H., Syvaoja, J. E., Stucki, M., Hubscher, U., Egly, J. M., and Wood, R. D. (2000) Genes Dev., 14, 349–359.

    CAS  PubMed  Google Scholar 

  11. Hoogstraten, D., Nigg, A. L., Heath, H. L., Mullenders, H., van Driel, R., Hoeijmakers, J. H., Vermeulen, W., and Houtsmuller, A. B. (2002) Mol. Cell, 10, 1163–1174.

    Article  CAS  PubMed  Google Scholar 

  12. Rademakers, S., Volker, M., Hoogstraten, D., Nigg, A. L., Mone, M. J., van Zeeland, A. A., Hoeijmakers, J. H., Houtsmuller, A. B., and Vermeulen, W. (2003) Mol. Cell. Biol., 23, 5755–5767.

    Article  CAS  PubMed  Google Scholar 

  13. Hoogstraten, D., Bergink, S., Verbiest, V. H., Luijsterburg, M. S., Geverts, B., Raams, A., Dinant, C., Hoeijmakers, J. H., Vermeulen, W., and Houtsmuller, A. B. (2008) J. Cell. Sci., 121, 2850–2859.

    Article  CAS  PubMed  Google Scholar 

  14. Shimizu, Y., Iwai, S., Hanaoka, F., and Sugasawa, K. (2003) EMBO J., 22, 164–173.

    Article  CAS  PubMed  Google Scholar 

  15. D’Errico, M., Parlanti, E., Teson, M., de Jesus, B. M., Degan, P., Calcagnile, A., Jaruga, P., Bjoras, M., Crescenzi, M., Pedrini, A. M., Egly, J. M., Zambruno, G., Stefanini, M., Dizdaroglu, M., and Dogliotti, E. (2006) EMBO J., 25, 4305–4315.

    Article  PubMed  Google Scholar 

  16. Hiyama, H., Yokoi, M., Masutani, C., Sugasawa, K., Maekawa, T., Tanaka, K., Hoeijmakers, J. H., and Hanaoka, F. (1999) J. Biol. Chem., 274, 28019–28025.

    Article  CAS  PubMed  Google Scholar 

  17. Schaeffer, L., Roy, R., Humbert, S., Moncollin, V., Vermeulen, W., Hoeijmakers, J. H., Chambon, P., and Egly, J. M. (1993) Science, 260, 58–63.

    Article  CAS  PubMed  Google Scholar 

  18. Matsuno, M., Kose, H., Okabe, M., and Hiromi, Y. (2007) Genes Cells, 12, 1289–1300.

    Article  CAS  PubMed  Google Scholar 

  19. Zhang, N., Liu, X., Li, L., and Legerski, R. (2007) DNA Repair, 6, 1670–1678.

    Article  CAS  PubMed  Google Scholar 

  20. Klungland, A., Hoss, M., Gunz, D., Constantinou, A., Clarkson, S. G., Doetsch, P. W., Bolton, P. H., Wood, R. D., and Lindahl, T. (1999) Mol. Cell, 3, 33–42.

    Article  CAS  PubMed  Google Scholar 

  21. Bomgarden, R. D., Lupardus, P. J., Soni, D. V., Yee, M. C., Ford, J. M., and Cimprich, K. A. (2006) EMBO J., 25, 2605–2614.

    Article  CAS  PubMed  Google Scholar 

  22. Wu, X., Shell, S. M., Yan, Z., and Zou, Y. (2006) Cancer Res., 66, 2997–3005.

    Article  CAS  PubMed  Google Scholar 

  23. Wu, X., Shell, S. M., Liu, Y., and Zou, Y. (2007) Oncogene, 26, 757–764.

    Article  CAS  PubMed  Google Scholar 

  24. Wold, M. S. (1997) Annu. Rev. Biochem., 66, 61–92.

    Article  CAS  PubMed  Google Scholar 

  25. Fanning, E., Klimovich, V., and Nager, A. R. (2006) Nucleic Acids Res., 34, 4126–4137.

    Article  CAS  PubMed  Google Scholar 

  26. Pestryakov, P. E., and Lavrik, O. I. (2008) Biochemistry (Moscow), 73, 1388–1404.

    Article  CAS  Google Scholar 

  27. Fitch, M. E., Nakajima, S., Yasui, A., and Ford, J. M. (2003) J. Biol. Chem., 278, 46906–46910.

    Article  CAS  PubMed  Google Scholar 

  28. Wang, Q. E., Zhu, Q., Wani, G., Chen, J., and Wani, A. A. (2004) Carcinogenesis, 25, 1033–1043.

    Article  CAS  PubMed  Google Scholar 

  29. Moser, J., Volker, M., Kool, H., Alekseev, S., Vrieling, H., Yasui, A., van Zeeland, A. A., and Mullenders, L. H. (2005) DNA Repair, 4, 571–582.

    Article  CAS  PubMed  Google Scholar 

  30. Nishi, R., Alekseev, S., Dinant, C., Hoogstraten, D., Houtsmuller, A. B., Hoeijmakers, J. H., Vermeulen, W., Hanaoka, F., and Sugasawa, K. (2009) DNA Repair, 8, 767–776.

    Article  CAS  PubMed  Google Scholar 

  31. Hey, T., Lipps, G., Sugasawa, K., Iwai, S., Hanaoka, F., and Krauss, G. (2002) Biochemistry, 41, 6583–6587.

    Article  CAS  PubMed  Google Scholar 

  32. Sugasawa, K., Ng, J. M., Masutani, C., Iwai, S., van der Spek, P. J., Eker, A. P., Hanaoka, F., Bootsma, D., and Hoeijmakers, J. H. (1998) Mol. Cell, 2, 223–232.

    Article  CAS  PubMed  Google Scholar 

  33. Batty, D., Rapic-Otrin, V. A., Levine, S., and Wood, R. D. (2000) J. Mol. Biol., 300, 275–290.

    Article  CAS  PubMed  Google Scholar 

  34. Sugasawa, K., Shimizu, Y., Iwai, S., and Hanaoka, F. (2002) DNA Repair, 1, 95–107.

    Article  CAS  PubMed  Google Scholar 

  35. Riedl, T., Hanaoka, F., and Egly, J. M. (2003) EMBO J., 22, 5293–5303.

    Article  CAS  PubMed  Google Scholar 

  36. Volker, M., Mone, M. J., Karmakar, P., van Hoffen, A., Schul, W., Vermeulen, W., Hoeijmakers, J. H., van Driel, R., van Zeeland, A. A., and Mullenders, L. H. (2001) Mol. Cell., 8, 213–224.

    Article  CAS  PubMed  Google Scholar 

  37. Reardon, J. T., and Sancar, A. (2003) Genes Dev., 17, 2539–2551.

    Article  CAS  PubMed  Google Scholar 

  38. Maltzeva, E. A., Rechkunova, N. I., Petruseva, I. O., Sil’nikov, V. N., Vermeulen, V., and Lavrik, O. I. (2006) Biochemistry (Moscow), 71, 270–278.

    Article  Google Scholar 

  39. Kesseler, K. J., Kaufmann, W. K., Reardon, J. T., Elston, T. C., and Sancar, A. (2007) J. Theor. Biol., 249, 361–375.

    Article  CAS  PubMed  Google Scholar 

  40. Krasikova, U. S., Rechkunova, N. I., Maltzeva, E. A., Petruseva, I. O., Sil’nikov, V. N., Zatsepin, T. S., Oretskaya, T. S., Sherer, O. D., and Lavrik, O. I. (2008) Biochemistry (Moscow), 73, 886–896.

    Article  CAS  Google Scholar 

  41. Van der Spek, P. J., Eker, A., Rademakers, S., Visser, C., Sugasawa, K., Masutani, C., Hanaoka, F., Bootsma, D., and Hoeijmakers, J. H. (1996) Nucleic Acids Res., 24, 2551–2559.

    Article  PubMed  Google Scholar 

  42. Araki, M., Masutani, C., Takemura, M., Uchida, A., Sugasawa, K., Kondoh, J., Ohkuma, Y., and Hanaoka, F. (2001) J. Biol. Chem., 276, 18665–18672.

    Article  CAS  PubMed  Google Scholar 

  43. Ng, J. M., Vermeulen, W., van der Horst, G. T., Bergink, S., Sugasawa, K., Vrieling, H., and Hoeijmakers, J. H. (2003) Genes Dev., 17, 1630–1645.

    Article  CAS  PubMed  Google Scholar 

  44. Sugasawa, K., Masutani, C., Uchida, A., Maekawa, T., van der Spek, P. J., Bootsma, D., Hoeijmakers, J. H., and Hanaoka, F. (1996) Mol. Cell. Biol., 16, 4852–4861.

    CAS  PubMed  Google Scholar 

  45. Masutani, C., Araki, M., Sugasawa, K., van der Spek, P. J., Yamada, A., Uchida, A., Maekawa, T., Bootsma, D., Hoeijmakers, J. H., and Hanaoka, F. (1997) Mol. Cell. Biol., 17, 6915–6923.

    CAS  PubMed  Google Scholar 

  46. Sugasawa, K., Ng, J. M., Masutani, C., Maekawa, T., Uchida, A., van der Spek, P. J., Eker, A. P., Rademakers, S., Visser, C., Aboussekhra, A., Wood, R. D., Hanaoka, F., Bootsma, D., and Hoeijmakers, J. H. (1997) Mol. Cell. Biol., 17, 6924–6931.

    CAS  PubMed  Google Scholar 

  47. Sugasawa, K., Okuda, Y., Saijo, M., Nishi, R., Matsuda, N., Chu, G., Mori, T., Iwai, S., Tanaka, K., and Hanaoka, F. (2005) Cell, 121, 387–400.

    Article  CAS  PubMed  Google Scholar 

  48. Nishi, R., Okuda, Y., Watanabe, E., Mori, T., Iwai, S., Masutani, C., Sugasawa, K., and Hanaoka, F. (2005) Mol. Cell. Biol., 25, 5664–5674.

    Article  CAS  PubMed  Google Scholar 

  49. Kusumoto, R., Masutani, C., Sugasawa, K., Iwai, S., Araki, M., Uchida, A., Mizukoshi, T., and Hanaoka, F. (2001) Mutat. Res., 485, 219–227.

    CAS  PubMed  Google Scholar 

  50. Sugasawa, K., Okamoto, T., Shimizu, Y., Masutani, C., Iwai, S., and Hanaoka, F. (2001) Genes Dev., 15, 507–521.

    Article  CAS  PubMed  Google Scholar 

  51. Buterin, T., Meyer, C., Giese, B., and Naegeli, H. (2005) Chem. Biol., 12, 913–922.

    Article  CAS  PubMed  Google Scholar 

  52. Maillard, O., Solyom, S., and Naegeli, H. (2007) PLoS Biol., 5, e79.

    Article  PubMed  Google Scholar 

  53. Min, J.-H., and Pavletich, N. P. (2007) Nature, 449, 570–575.

    Article  CAS  PubMed  Google Scholar 

  54. Maillard, O., Camenisch, U., Blagoev, K. B., and Naegeli, H. (2008) Mutat. Res., 658, 271–286.

    Article  CAS  PubMed  Google Scholar 

  55. Camenisch, U., Trautlein, D., Clement, F. C., Fei, J., Leitenstorfer, A., Ferrando-May, E., and Naegeli, H. (2009) EMBO J., 28, 2387–2399.

    Article  CAS  PubMed  Google Scholar 

  56. Sugasawa, K., Akagi, J., Nishi, R., Iwai, S., and Hanaoka, F. (2009) Mol. Cell., 36, 642–653.

    Article  CAS  PubMed  Google Scholar 

  57. Blagoev, K. B., Alexandrov, B. S., Goodwin, E. H., and Bishop, A. R. (2006) DNA Repair, 5, 863–867.

    Article  CAS  PubMed  Google Scholar 

  58. Maillard, O., Camenisch, U., Clement, F. C., Blagoev, K. B., and Naegeli, H. (2007) Trends Biochem. Sci., 32, 494–499.

    Article  CAS  PubMed  Google Scholar 

  59. Janicijevic, A., Sugasawa, K., Shimizu, Y., Hanaoka, F., Wijgers, N., Djurica, M., Hoeijmakers, J. H., and Wyman, C. (2003) DNA Repair, 2, 325–336.

    Article  CAS  PubMed  Google Scholar 

  60. Yokoi, M., Masutani, C., Maekawa, T., Sugasawa, K., Ohkuma, Y., and Hanaoka, F. (2000) J. Biol. Chem., 275, 9870–9875.

    Article  CAS  PubMed  Google Scholar 

  61. Yang, Z. G., Liu, Y., Mao, L. Y., Zhang, J. T., and Zou, Y. (2002) Biochemistry, 41, 13012–13020.

    Article  CAS  PubMed  Google Scholar 

  62. Li, L., Lu, X., Peterson, C. A., and Legerski, R. J. (1995) Mol. Cell. Biol., 15, 5396–5402.

    CAS  PubMed  Google Scholar 

  63. Li, L., Elledge, S. J., Peterson, C. A., Bales, E. S., and Legerski, R. J. (1994) Proc. Natl. Acad. Sci. USA, 91, 5012–5016.

    Article  CAS  PubMed  Google Scholar 

  64. Park, C. H., Mu, D., Reardon, J. T., and Sancar, A. (1995) J. Biol. Chem., 270, 4896–4902.

    Article  CAS  PubMed  Google Scholar 

  65. Missura, M., Buterin, T., Hindges, R., Hubscher, U., Kasparkova, J., Brabec, V., and Naegeli, H. (2001) EMBO J., 20, 3554–3564.

    Article  CAS  PubMed  Google Scholar 

  66. Schweizer, U., Hey, T., Lipps, G., and Krauss, G. (1999) Nucleic Acids Res., 27, 3183–3189.

    Article  CAS  PubMed  Google Scholar 

  67. Wang, M., Mahrenholz, A., and Lee, S. (2000) Biochemistry, 39, 6433–6439.

    Article  CAS  PubMed  Google Scholar 

  68. Hey, T., Lipps, G., and Krauss, G. (2001) Biochemistry, 40, 2901–2910.

    Article  CAS  PubMed  Google Scholar 

  69. Camenisch, U., Dip, R., Schumacher, S. B., Schuler, B., and Naegeli, H. (2006) Nat. Struct. Mol. Biol., 13, 278–284.

    Article  CAS  PubMed  Google Scholar 

  70. Yang, Z., Roginskaya, M., Colis, L. C., Basu, A. K., Shell, S. M., Liu, Y., Musich, P. R., Harris, C. M., Harris, T. M., and Zou, Y. (2006) Biochemistry, 45, 15921–15930.

    Article  CAS  PubMed  Google Scholar 

  71. Saijo, M., Kuraoka, I., Masutani, C., Hanaoka, F., and Tanaka, K. (1996) Nucleic Acids Res., 24, 4719–4724.

    Article  CAS  PubMed  Google Scholar 

  72. Orelli, B., McClendon, T. B., Tsodikov, O. V., Ellenberger, T., Niedernhofer, L. J., and Scharer, O. D. (2010) J. Biol. Chem., 285, 3705–3712.

    Article  CAS  PubMed  Google Scholar 

  73. Lavrik, O. I., Kolpashchikov, D. M., Weisshart, K., Nasheuer, H. P., Khodyreva, S. N., and Favre, A. (1999) Nucleic Acids Res., 27, 4235–4240.

    Article  CAS  PubMed  Google Scholar 

  74. Bochkareva, E., Korolev, S., Lees-Miller, S. P., and Bochkarev, A. (2002) EMBO J., 21, 1855–1863.

    Article  CAS  PubMed  Google Scholar 

  75. Lavrik, O. I., Nasheuer, H. P., Weisshart, K., Wold, M. S., Prasad, R., Beard, W. A., Wilson, S. H., and Favre, A. (1998) Nucleic Acids Res., 26, 602–607.

    Article  CAS  PubMed  Google Scholar 

  76. De Laat, W. L., Appeldoorn, E., Sugasawa, K., Weterings, E., Jaspers, N. G., and Hoeijmakers, J. H. (1998) Genes Dev., 12, 2598–2609.

    Article  PubMed  Google Scholar 

  77. Kolpashchikov, D. M., Khodyreva, S. N., Khlimankov, D. Y., Wold, M. S., Favre, A., and Lavrik, O. I. (2001) Nucleic Acids Res., 29, 373–379.

    Article  CAS  PubMed  Google Scholar 

  78. Tapias, A., Auriol, J., Forget, D., Enzlin, J. H., Scharer, O. D., Coin, F., Coulombe, B., and Egly, J. M. (2004) J. Biol. Chem., 279, 19074–19083.

    Article  CAS  PubMed  Google Scholar 

  79. Hermanson-Miller, I. L., and Turchi, J. J. (2002) Biochemistry, 41, 2402–2408.

    Article  CAS  PubMed  Google Scholar 

  80. Lee, J. H., Park, C. J., Arunkumar, A. I., Chazin, W. J., and Choi, B. S. (2003) Nucleic Acids Res., 31, 4747–4754.

    Article  CAS  PubMed  Google Scholar 

  81. Patrick, S. M., and Turchi, J. J. (2002) J. Biol. Chem., 277, 16096–16101.

    Article  CAS  PubMed  Google Scholar 

  82. Gomes, X. V., and Burgers, P. M. (2001) J. Biol. Chem., 276, 34768–34775.

    Article  CAS  PubMed  Google Scholar 

  83. Della Vecchia, M. J., Croteau, D. L., Skorvaga, M., Dezhurov, S. V., Lavrik, O. I., and van Houten, B. (2004) J. Biol. Chem., 279, 45245–45256.

    Article  Google Scholar 

  84. Khodyreva, S. N., and Lavrik, O. I. (2005) Curr. Med. Chem., 12, 641–655.

    Article  CAS  PubMed  Google Scholar 

  85. Rechkunova, N. I., and Lavrik, O. I. (2010) Subcell. Biochem., 50, 251–277.

    Article  CAS  PubMed  Google Scholar 

  86. Maltseva, E. A., Rechkunova, N. I., Gillet, L. C., Petruseva, I. O., Scharer, O. D., and Lavrik, O. I. (2007) Biochim. Biophys. Acta, 1770, 781–789.

    CAS  PubMed  Google Scholar 

  87. Heflich, R. H., and Neft, R. E. (1994) Mutat. Res., 318, 73–114.

    CAS  PubMed  Google Scholar 

  88. Gillet, L. C., Alzeer, J., and Scharer, O. D. (2005) Nucleic Acids Res., 33, 1961–1969.

    Article  CAS  PubMed  Google Scholar 

  89. Shivji, M. K., Moggs, J. G., Kuraoka, I., and Wood, R. D. (1999) Meth. Mol. Biol., 113, 373–392.

    CAS  Google Scholar 

  90. Gunz, D., Hess, M. T., and Naegeli, H. (1996) J. Biol. Chem., 271, 25089–25098.

    Article  CAS  PubMed  Google Scholar 

  91. Geacintov, N. E., Broyde, S., Buterin, T., Naegeli, H., Wu, M., Yan, S., and Patel, D. J. (2002) Biopolymers, 65, 202–210.

    Article  CAS  PubMed  Google Scholar 

  92. Mocquet, V., Kropachev, K., Kolbanovskiy, M., Kolbanovskiy, A., Tapias, A., Cai, Y., Broyde, S., Geacintov, N. E., and Egly, J. M. (2007) EMBO J., 26, 2923–2932.

    Article  CAS  PubMed  Google Scholar 

  93. Maltseva, E. A., Rechkunova, N. I., Petruseva, I. O., Vermeulen, W., Scharer, O. D., and Lavrik, O. I. (2008) Bioorg. Chem., 36, 77–84.

    Article  CAS  PubMed  Google Scholar 

  94. Petruseva, I. O., Tikhanovich, I. S., Chelobanov, B. P., and Lavrik, O. I. (2008) J. Mol. Recognit., 21, 154–162.

    Article  CAS  PubMed  Google Scholar 

  95. Meisenheimer, K. M., and Koch, T. H. (1997) Crit. Rev. Biochem. Mol. Biol., 32, 101–140.

    Article  CAS  PubMed  Google Scholar 

  96. Nakano, T., Katafuchi, A., Shimizu, R., Terato, H., Suzuki, T., Tauchi, H., Makino, K., Skorvaga, M., van Houten, B., and Ide, H. (2005) Nucleic Acids Res., 33, 2181–2191.

    Article  CAS  PubMed  Google Scholar 

  97. Wakasugi, M., and Sancar, A. (1999) J. Biol. Chem., 274, 18759–18768.

    Article  CAS  PubMed  Google Scholar 

  98. Krasikova, Y. S., Rechkunova, N. I., Maltseva, E. A., Petruseva, I. O., and Lavrik, O. I. (2010) Nucleic Acids Res., 38, 8083–8094.

    Article  CAS  PubMed  Google Scholar 

  99. Salas, T. R., Petruseva, I., Lavrik, O., Bourdoncle, A., Mergny, J. L., Favre, A., and Saintome, C. (2006) Nucleic Acids Res., 34, 4857–4865.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, pr. Akademika Lavrent’eva 8, 630090, Novosibirsk, Russia

    N. I. Rechkunova, Yu. S. Krasikova & O. I. Lavrik

Authors
  1. N. I. Rechkunova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yu. S. Krasikova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. O. I. Lavrik
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to N. I. Rechkunova.

Additional information

Original Russian Text © N. I. Rechkunova, Yu. S. Krasikova, O. I. Lavrik, 2011, published in Biokhimiya, 2011, Vol. 76, No. 1, pp. 32–45.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rechkunova, N.I., Krasikova, Y.S. & Lavrik, O.I. Nucleotide excision repair: DNA damage recognition and preincision complex assembly. Biochemistry Moscow 76, 24–35 (2011). https://doi.org/10.1134/S0006297911010056

Download citation

  • Received:

  • Revised:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0006297911010056

Key words

Search

Navigation