Skip to main content
SpringerLink
Log in

Mechanisms of tumor promotion by reactive oxygen species

  • Review
  • Published:
Biochemistry (Moscow) Aims and scope Submit manuscript

Abstract

This review analyzes the available information concerning mechanisms of non-genotoxic action of reactive oxygen species (ROS) during tumor promotion and pathways of their generation under the influence of chemical compounds. Special attention is given to the ability of ROS to induce pseudohypoxia through inhibition of prolyl oxidase, which is an oxygen sensor in the cell. Functions of HIF-1α as a main contributor to the ROS-induced promotion are analyzed. Data suggest that an unregulated high level of HIF-1α in the cell could induce the development of tumors. Hypothetical possibilities of ROS production under the influence of different environmental pollutants, which are promoters of tumorigenesis, include functioning of cytochrome P450 during oxidation of substrates, functioning of the mitochondrial respiratory chain, and action of peroxisome proliferators.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Kobliakov, V. A. (1998) Biochemistry (Moscow), 63, 885–898.

    Google Scholar 

  2. Peters, J. M., Cattley, R. C., and Gonzalez, F. J. (1997) Carcinogenesis, 18, 2029–2033.

    Article  CAS  PubMed  Google Scholar 

  3. Yamamoto, Y., Moore, R., Goldsworthy, T. L., Negishi, M., and Maronpot, R. R. (2004) Cancer Res., 64, 7197–7200.

    Article  CAS  PubMed  Google Scholar 

  4. Courtney, G. H., Ho, A., Yoshioka, N., and Dowdy, S. F. (2006) Mol. Cell. Biol., 26, 4701–4711.

    Article  CAS  Google Scholar 

  5. Menon, S., Sarsour, E., Spitz, D., Higashikuba, R., Sturm, M., Zhang, H., and Gaswami, P. (2003) Cancer Res., 63, 2109–2117.

    CAS  PubMed  Google Scholar 

  6. Wu, W. S. (2006) Cancer Metast. Rev., 25, 695–705.

    Article  CAS  Google Scholar 

  7. Adler, V., Zhimin, Y., Tew, K. D., and Ronai, Z. (1999) Oncogene, 18, 6104–6111.

    Article  CAS  PubMed  Google Scholar 

  8. Adler, V., Yin, Z., Fuchs, S. Y., Benezra, M., Rosario, L., Tew, K. D., Pincus, M. R., Sardana, M., Henderson, C. J., Wolf, C. R., and Ronai, Z. (1999) EMBO J., 18, 1321–1334.

    Article  CAS  PubMed  Google Scholar 

  9. Villafania, A., Anwar, K., Amar, S., Chie, L., Way, D., Chung, D. L., Adler, V., and Ronai, Z. (2000) Ann. Clin. Lab. Sci., 30, 57–64.

    CAS  PubMed  Google Scholar 

  10. Giles, G. (2006) Curr. Pharm. Design, 12, 4427–4443.

    Article  CAS  Google Scholar 

  11. Fujiki, H., and Suganuma, M. (2009) Prog. Mol. Subcell. Biol., 46, 221–254.

    Article  CAS  PubMed  Google Scholar 

  12. Slaga, T. J., Klein-Szanto, A. J., Triplett, L. L., Yotti, L. P., and Trosko, K. E. (1981) Science, 213, 1023–1025.

    Article  CAS  PubMed  Google Scholar 

  13. Rohr-Udilova, N. V., Stolze, K., Sagmeister, S., Nohl, H., Schulte-Hermann, R., and Grasl-Kraupp, B. (2008) Mol. Nutr. Food Res., 52, 352–359.

    Article  CAS  PubMed  Google Scholar 

  14. Giri, U., Iqbal, M., and Athar, M. (1996) Carcinogenesis, 17, 2023–2028.

    Article  CAS  PubMed  Google Scholar 

  15. Teufelhofer, O., Parzefall, W., Kainzbauer, E., Ferk, F., Freiler, C., Knasmuller, S., Elbling, L., Thurman, R., and Schulte-Herman, R. (2005) Carcinogenesis, 26, 319–329.

    Article  CAS  PubMed  Google Scholar 

  16. Peters, J. M., and Gonzalez, F. (2005) J. Mol. Med., 83, 774–785.

    Article  CAS  PubMed  Google Scholar 

  17. Ohshima, H., Tatemichi, M., and Sawa, T. (2003) Arch. Biochem. Biophys., 417, 3–11.

    Article  CAS  PubMed  Google Scholar 

  18. Keisari, Y., Flescher, E., and Geva, I. (1984) Int. J. Cancer, 34, 845–848.

    Article  CAS  PubMed  Google Scholar 

  19. Cerutti, P. A. (1985) Science, 227, 375–381.

    Article  CAS  PubMed  Google Scholar 

  20. Yeldandi, A. V., Rao, M. S., and Reddy, J. K. (2000) Mutat. Res., 448, 159–177.

    CAS  PubMed  Google Scholar 

  21. Alsharif, N. Z., Lawson, T., and Stohs, S. J. (1994) Toxicology, 92, 39–51.

    Article  CAS  PubMed  Google Scholar 

  22. Dostalek, M., Brooks, J. D., Hardy, K. D., Milne, G. L., Moore, M. M., Sharma, S., Morrow, J. D., and Guengerich, F. R. (2007) Mol. Pharmacol., 72, 1419–1424.

    Article  CAS  PubMed  Google Scholar 

  23. Park, J. Y., Shigenaga, M. K., and Ames, B. N. (1996) Proc. Natl. Acad. Sci. USA, 93, 2322–2327.

    Article  CAS  PubMed  Google Scholar 

  24. Schulte-Hermann, R., Timmermann-Trosiener, I., Barthel, G., and Bursch, W. (1990) Cancer Res., 50, 5127–5135.

    CAS  PubMed  Google Scholar 

  25. Stohs, S. J., Alsharif, N. Z., Shara, M. A., Al-Bayati, Z. A., and Wahba, Z. Z. (1991) Adv. Exp. Med. Biol., 283, 827–831.

    CAS  PubMed  Google Scholar 

  26. Gottlieb, E., and Tomlinson, I. P. (2005) Nat. Rev. Cancer, 5, 857–866.

    Article  CAS  PubMed  Google Scholar 

  27. Lee, K., Roth, R., and LaPres, J. (2007) Pharmacol. Therap., 113, 229–246.

    Article  CAS  Google Scholar 

  28. Chandel, N. S., and Budinger, G. R. (2007) Free Rad. Biol. Med., 42, 165–174.

    Article  CAS  PubMed  Google Scholar 

  29. Piret, J. P., Minet, E., Cosse, J. P., Ninane, N., Debacq, C., Raes, M., and Michiels, C. (2005) J. Biol. Chem., 280, 9336–9644.

    Article  CAS  PubMed  Google Scholar 

  30. King, A., Selak, M. A., and Gottlieb, E. (2006) Oncogene, 25, 4675–4682.

    Article  CAS  PubMed  Google Scholar 

  31. Koivunen, P., Hirsil, M., Remes, A. M., Hassinen, I. E., Kivirikko, K. I., and Myllyharju, J. (2007) J. Biol. Chem., 282, 4524–4532.

    Article  CAS  PubMed  Google Scholar 

  32. Chandel, N. S., McClintock, D. S., Feliciano, C. E., Wood, T. M., Melendez, J. A., Rodriguez, A. M., and Schumaker, R. T. (2000) J. Biol. Chem., 275, 25130–25138.

    Article  CAS  PubMed  Google Scholar 

  33. Jung, S. N., Yang, W. K., Kim, J., Kim, H. S., Kim, E. J., Yun, H., Park, H., Kim, S. S., Choe, W., Kang, I., and Ha, J. (2008) Carcinogenesis, 29, 713–721.

    Article  CAS  PubMed  Google Scholar 

  34. Mansfield, K. D., Guzy, R. D., Pan, Y., Young, R. M., Cash, T. P., Schumaker, P. T., and Simon, M. C. (2005) Cell Metab., 1, 393–399.

    Article  CAS  PubMed  Google Scholar 

  35. Kohl, R., Zhou, J., and Brune, B. (2006) Free Rad. Biol. Med., 40, 1430–1442.

    Article  PubMed  CAS  Google Scholar 

  36. Haddad, J. J. (2002) Eur. Cytokine Netw., 13, 250–260.

    CAS  PubMed  Google Scholar 

  37. Park, J. H., Kim, T. Y., Jong, H. S., Kim, T. Y., Chun, Y. S., Park, J. W., Lee, C. T., Jung, H. C., Kim, N. K., and Bang, Y. J. (2003) Clin. Cancer Res., 9, 433–440.

    CAS  PubMed  Google Scholar 

  38. Yang, H., and Kaelin, W. G., Jr. (2001) Cell Growth Differentiation, 12, 447–455.

    CAS  PubMed  Google Scholar 

  39. Pollard, P. J., Briere, J. J., Alam, N. A., Barwell, J., Barclay, E., Wortham, N. C., Hunt, T., Mitchell, M., Olpin, S., Moat, S. J., Hargreaves, I. P., Heales, S. J., Chung, Y. L., Griffiths, J. R., Dalgleish, A., McGrath, J. A., Gleeson, M. J., Hodgson, S. V., Poulsom, R., Rustin, P., and Tomlinson, I. P. (2005) Hum. Mol. Genet., 14, 2231–2239.

    Article  CAS  PubMed  Google Scholar 

  40. Baysal, B. E. (2006) Endocr. Pathol., 17, 203–212.

    Article  CAS  PubMed  Google Scholar 

  41. Chen, H., and Costa, M. (2006) Exp. Biol. Med. (Maywood), 231, 1474–1480.

    CAS  Google Scholar 

  42. Ahn, Y. S., Chemeris, G. Y., Turusov, V. S., and Bannasch, P. (1994) Toxicol. Pathol., 22, 415–422.

    Article  CAS  PubMed  Google Scholar 

  43. Arulkumaran, S., Ramprasath, V. R., Shanthi, P., and Sachdanandam, P. (2007) Chem. Biol. Interact., 167, 99–106.

    Article  CAS  PubMed  Google Scholar 

  44. Zhao, T., Zhang, C. P., Liu, Z. H., Wu, L. Y., Huang, X., Wu, H. T., Xiong, L., Wang, X., Wang, X. M., Zhu, L. L., and Fan, M. (2008) FEBS J., 275, 1824–1834.

    Article  CAS  PubMed  Google Scholar 

  45. Lee, S. H., Lee, M. Y., and Han, H. J. (2008) Cell Prolif., 41, 230–247.

    Article  CAS  PubMed  Google Scholar 

  46. Di Carlo, A., De Mori, R., Martelli, F., Pompilio, G., Capogrossi, M. C., and Germani, A. (2004) J. Biol. Chem., 279, 16332–16338.

    Article  PubMed  CAS  Google Scholar 

  47. Lin, Q., Lee, Y. J., and Yun, Z. (2006) J. Biol. Chem., 281, 30678–30683.

    Article  CAS  PubMed  Google Scholar 

  48. Cowden, K. D., Robertson, S. E., Weaver, V. M., and Simon, M. C. (2005) Mol. Biol. Cell, 16, 1901–1912.

    Article  CAS  Google Scholar 

  49. Krishnamachary, B., Berg-Dixon, S., Kelly, B., Agani, F., Feldser, D., and Ferreira, G. (2003) Cancer Res., 63, 1138–1143.

    CAS  PubMed  Google Scholar 

  50. Piret, J. P., Minet, E., Cosse, J. P., Ninane, N., Debacq, C., Raes, M., and Michiels, C. (2005) J. Biol. Chem., 280, 9336–9644.

    Article  CAS  PubMed  Google Scholar 

  51. Brahimi-Horn, M. C. (2007) FEBS Lett., 581, 3582–3591.

    Article  CAS  PubMed  Google Scholar 

  52. Gwak, G. Y., Yoon, J. H., Kim, K. M., Lee, H. S., Chung, J. W., and Gores, G. J. (2005) J. Hepatol., 42, 358–364.

    Article  CAS  PubMed  Google Scholar 

  53. Lu, C. W., Lin, S. C., Chen, K. F., Lai, Y. Y., and Tsai, S. J. (2008) J. Biol. Chem., 283, 28106–28114.

    Article  CAS  PubMed  Google Scholar 

  54. Minamino, T., Mitsialis, S. A., and Kourembanas, S. (2001) Mol. Cell Biol., 21, 3336–3342.

    Article  CAS  PubMed  Google Scholar 

  55. Yatabe, N., Kyo, S., Maida, Y., Nishi, H., Nakamura, M., Kanaya, T., Tanaka, T., Tanaka, M., Isaka, K., Ogawa, S., and Inoue, M. (2004) Oncogene, 23, 3708–3715.

    Article  CAS  PubMed  Google Scholar 

  56. Nishi, H., Nakada, T., Kyo, S., Inoue, M., Shay, J. W., and Isaka, K. (2004) Mol. Cell Biol., 24, 6076–6083.

    Article  CAS  PubMed  Google Scholar 

  57. Anderson, C. J., Hoare, S. F., Ashcroft, M., Bilsland, A. E., and Keith, W. N. (2006) Oncogene, 25, 61–69.

    CAS  PubMed  Google Scholar 

  58. Phesse, T. J., and Clarke, A. R. (2009) Br. J. Cancer, 100, 221–227.

    Article  CAS  PubMed  Google Scholar 

  59. Wicha, M. S., Liu, S., and Dontu, G. (2006) Cancer Res., 66, 1883–1890.

    Article  CAS  PubMed  Google Scholar 

  60. Simon, M. C., and Keith, B. (2008) Nat. Rev. Mol. Cell Biol., 9, 285–296.

    Article  CAS  PubMed  Google Scholar 

  61. Keith, B., and Simon, M. C. (2007) Cell, 129, 465–472.

    Article  CAS  PubMed  Google Scholar 

  62. Cipolleschi, M. G., Dello Sbarba, P., and Olivotto, M. (1993) Blood, 82, 2031–2037.

    CAS  PubMed  Google Scholar 

  63. Covello, K. L., Kehler, J., Yu, H., Arsham, A. M., Hu, C. J., Labosky, P. A., Simon, M., and Keith, B. (2006) Genes Dev., 20, 557–570.

    Article  CAS  PubMed  Google Scholar 

  64. Gustafsson, M. V., Zheng, X., Pereira, T., Gradin, K., Jin, S., Lundkwist, J., Ruas, J. L., Poelinger, L., Lendahl, U., and Bondesson, M. (2005) Dev. Cell, 9, 617–628.

    Article  CAS  PubMed  Google Scholar 

  65. Diez, H., Fischer, A., Winkler, A., Hu, C. J., Hatzopoulos, A. K., Breier, G., and Gessler, M. (2007) Exp. Cell Res., 313, 1–9.

    Article  CAS  PubMed  Google Scholar 

  66. Poellinger, L., and Lendahl, U. (2008) Curr. Opin. Genet. Dev., 18, 449–454.

    Article  CAS  PubMed  Google Scholar 

  67. Sahlgren, C., Gustafsson, M., Jin, S., Poellinger, L., and Lendahl, U. (2008) Proc. Natl. Acad. Sci. USA, 105, 6392–6397.

    Article  CAS  PubMed  Google Scholar 

  68. Wilson, A., and Radtke, F. (2006) FEBS Lett., 580, 2860–2868.

    Article  CAS  PubMed  Google Scholar 

  69. Comerford, K. M., Wallace, T. J., Karhausen, J., Louis, N. A., Montalto, M. C., and Sean, P. (2002) Cancer Res., 62, 3387–3394.

    CAS  PubMed  Google Scholar 

  70. Valko, M., Rhodes, C. J., Moncol, J., Izakovic, M., and Mazur, M. (2006) Chem. Biol. Interact., 160, 1–40.

    Article  CAS  PubMed  Google Scholar 

  71. Galanis, A., Pappa, A., Giannakakis, A., Lanitis, E., Dangaj, D., and Sandaltzopoulos, R. (2008) Cancer Lett., 266, 12–20.

    Article  CAS  PubMed  Google Scholar 

  72. Schmid, T., Zhou, J., and Brune, B. (2004) J. Cell Mol. Med., 8, 423–431.

    Article  CAS  PubMed  Google Scholar 

  73. Peng, X. H., Karna, P., Cao, Z., Jiang, B. H., Zhou, M., and Yang, L. (2006) J. Biol. Chem., 281, 25903–25914.

    Article  CAS  PubMed  Google Scholar 

  74. Yang, L., Cao, Z., Li, F., Post, D. E., van Meir, E. G., Zhong, H., and Wood, W. C. (2004) Gene Ther., 11, 1215–1223.

    Article  CAS  PubMed  Google Scholar 

  75. Villafania, A., Anwar, K., Amar, S., Chie, L., Way, D., Chung, D. L., Adler, V., and Ronai, Z. (2000) Ann. Clin. Lab. Sci., 30, 57–64.

    CAS  PubMed  Google Scholar 

  76. Duffy, M. J., O’Donovan, N., Brennan, D. J., Gallagher, W. M., and Ryan, B. M. (2007) Cancer Lett., 249, 49–60.

    Article  CAS  PubMed  Google Scholar 

  77. Hsue, S. S., Wang, W. C., Chen, Y. K., and Lin, L. M. (2008) Int. J. Exp. Pathol., 89, 309–320.

    Article  CAS  PubMed  Google Scholar 

  78. Abu-Hamad, S., Zaid, H., Israelson, A., Nahon, E., and Shoshan-Barmatz, V. (2008) J. Biol. Chem., 283, 13482–13490.

    Article  CAS  PubMed  Google Scholar 

  79. Vyssokikh, M., and Brdiczka, D. (2004) Mol. Cell Biochem., 256/257, 117–126.

    Article  CAS  Google Scholar 

  80. Pastorino, J. G., and Hoek, J. B. (2003) Curr. Med. Chem., 10, 1535–1551.

    Article  CAS  PubMed  Google Scholar 

  81. Sun, L., Shukair, S., Naik, T., Moazed, F., and Ardehali, H. (2008) Mol. Cell. Biol., 28, 1007–1017.

    Article  CAS  PubMed  Google Scholar 

  82. Abu-Hamad, S., Arbel, N., Calo, D., Arzoine, L., Israelson, A., Keinan, N., Ben-Romano, R., Friedman, O., and Shoshan-Barmatz, V. (2009) J. Cell. Sci., 122, 1906–1916.

    Article  CAS  PubMed  Google Scholar 

  83. Li, J., Zhang, X., Sejas, D. P., Bagby, G., and Pang, Q. (2004) J. Biol. Chem., 279, 41275–41279.

    Article  CAS  PubMed  Google Scholar 

  84. Maiguel, D. A., Jones, L., Chakravarty, D., Yang, C., and Carrier, F. (2004) Mol. Cell. Biol., 24, 3703–3711.

    Article  CAS  PubMed  Google Scholar 

  85. Li, J., Zhang, X., Sejas, D. P., and Pang, Q. (2005) Leuk. Res., 29, 1415–1423.

    Article  CAS  PubMed  Google Scholar 

  86. Piret, J. P., Minet, E., Cosse, J. P., Ninane, N., Debacq, C., Raes, M., and Michiels, C. (2005) J. Biol. Chem., 280, 9336–9644.

    Article  CAS  PubMed  Google Scholar 

  87. Radisky, D. C. (2005) J. Cell Sci., 118, 4325–4326.

    Article  CAS  PubMed  Google Scholar 

  88. Cannito, S., Novo, E., Compagnone, A., Valfri di Bonzo, L., Busletta, C., Zamara, E., Paternostro, C., Povero, D., Bandino, A., Bozzo, F., Cravanzola, C., Bravoco, V., Colombatto, S., and Parola, M. (2008) Carcinogenesis, 29, 2267–2278.

    Article  CAS  PubMed  Google Scholar 

  89. Imai, T., Horiuchi, A., Wang, C., Oka, K., Ohira, S., Nikaido, T., and Konishi, I. (2003) Am. J. Pathol., 163, 1437–1447.

    CAS  PubMed  Google Scholar 

  90. Russell, R. C., and Ohh, M. (2007) Cell Cycle, 6, 56–59.

    CAS  PubMed  Google Scholar 

  91. Leong, K. G., Niessen, K., Kulic, I., Raouf, A., Eaves, C., Pollet, I., and Karsan, A. (2007) J. Exp. Med., 204, 2935–2948.

    Article  CAS  PubMed  Google Scholar 

  92. Peinado, H., Carmen Iglesias-de la Cruz, M., Olmeda, D., Csiszar, K., Fong, K., Vega, S., Nieto, M., Cano, A., and Portillo, F. (2005) EMBO J., 24, 3446–3458.

    Article  CAS  PubMed  Google Scholar 

  93. Huber, M. A., Kraut, N., and Beug, H. (2005) Curr. Opin. Cell Biol., 17, 548–558.

    Article  CAS  PubMed  Google Scholar 

  94. Zavadil, J., and Boettinger, E. P. (2005) Oncogene, 24, 5764–5774.

    Article  CAS  PubMed  Google Scholar 

  95. Yang, M. H., and Wu, K. J. (2008) Cell Cycle, 7, 2090–2096.

    Article  CAS  PubMed  Google Scholar 

  96. Yang, M. H., Wu, M. Z., Chiou, S. H., Chen, P. M., Chang, S. Y., Liu, C. J., Teng, S. C., and Wu, K. J. (2008) Nat. Cell Biol., 10, 295–305.

    Article  CAS  PubMed  Google Scholar 

  97. Baghi, M., and Stohs, S. J. (1993) Free Rad. Biol. Med., 14, 11–18.

    Article  Google Scholar 

  98. Shertzer, H. G., Clay, C. D., Genter, M. B., Chames, M. C., Schneider, S. N., Oakley, G. G., Nebert, D. W., and Dalton, T. P. (2004) Free Rad. Biol. Med., 36, 618–631.

    Article  CAS  PubMed  Google Scholar 

  99. Schlezinger, J. J., Struntz, W. D., Goldstone, J. V., and Stegeman, J. J. (2006) Aquat. Toxicol., 77, 422–432.

    Article  CAS  PubMed  Google Scholar 

  100. Dostalek, M., Brooks, J. D., Hardy, K. D., Milne, G. L., Moore, M. M., Sharma, S., Morrow, J. D., and Guengerich, F. P. (2007) Mol. Pharmacol., 72, 1419–1424.

    Article  CAS  PubMed  Google Scholar 

  101. Shertzer, H. G., Genter, M. B., Shen, D., Nebert, D. W., Chen, Y., and Dalton, T. P. (2006) Toxicol. Appl. Pharmacol., 217, 363–374.

    Article  CAS  PubMed  Google Scholar 

  102. Howell, A. N., and Sager, R. (1978) Proc. Natl. Acad. Sci. USA, 75, 2358–2362.

    Article  CAS  PubMed  Google Scholar 

  103. Giguere, L., and Morais, R. (1981) Somatic Cell Genet., 7, 457–471.

    Article  CAS  PubMed  Google Scholar 

  104. Jonasson, J., Povey, S., and Harris, H. (1977) J. Cell Sci., 24, 217–254.

    CAS  PubMed  Google Scholar 

  105. Biswas, G., Guha, M., and Avadhani, N. G. (2005) Gene, 354, 132–139.

    Article  CAS  PubMed  Google Scholar 

  106. Amuthan, G., Biswas, G., Zhang, S. Y., Klein-Szanto, A., Vijayasarathy, C., and Avadhani, N. G. (2001) EMBO J., 20, 1910–1920.

    Article  CAS  PubMed  Google Scholar 

  107. Biswas, G., Anandatheerthavarada, H. K., and Avadhani, N. G. (2005) Cell Death Differ., 12, 266–278.

    Article  CAS  PubMed  Google Scholar 

  108. Baghi, M., and Stohs, S. J. (1993) Free Rad. Biol. Med., 14, 11–18.

    Article  Google Scholar 

  109. Stohs, S. J., Shara, M. A., Alsharif, N. Z., Wahba, Z. Z., and Al-Bayati, Z. A. (1990) Toxicol. Appl. Pharmacol., 106, 126–135.

    Article  CAS  PubMed  Google Scholar 

  110. Alsharif, N. Z., Grandjean, C. J., Murray, W. J., and Stohs, S. J. (1990) Xenobiotica, 20, 979–988.

    Article  CAS  PubMed  Google Scholar 

  111. Bagchi, M., Bagchi, D., and Stohs, S. J. (1996) Arch. Environ. Contam. Toxicol., 30, 418–422.

    Article  CAS  PubMed  Google Scholar 

  112. Senft, A., Dalton, T. P., Nebert, D. W., Genter, M. B., Hutchinson, R. J., and Shertzer, H. G. (2002) Toxicol. Appl. Pharmacol., 178, 15–21.

    Article  CAS  PubMed  Google Scholar 

  113. Chandel, N. S., and Budinger, G. R. (2007) Free Rad. Biol. Med., 42, 165–174.

    Article  CAS  PubMed  Google Scholar 

  114. Elchuri, S., Oberley, T. D., Qi, W., Eisenstein, R. S., Jackson, R. L., van Remmen, H., Epstein, C. H., and Huang, T. T. (2005) Oncogene, 24, 367–380.

    Article  CAS  PubMed  Google Scholar 

  115. Zhao, Y., Chaiswing, L., Oberley, T. D., Batinic-Haberle, I., and St. Clair, W. (2005) Cancer Res., 65, 1401–1405.

    Article  CAS  PubMed  Google Scholar 

  116. Oberley, T. D., Xue, Y., Zhao, Y., Kiningham, K., Szweda, L. I., and St. Clair, D. K. (2004) Antioxid. Redox Signal., 6, 537–548.

    Article  CAS  PubMed  Google Scholar 

  117. Genter, M. B., Clay, C. D., Dalton, T. P., Dong, H., Nebert, D. W., and Shertzer, H. G. (2006) Biochem. Biophys. Res. Commun., 342, 1375–1381.

    Article  CAS  PubMed  Google Scholar 

  118. Senft, A., Dalton, T. P., Nebert, D. W., Genter, M. B., Puga, A., Hutchinson, R. J., Kerzee, J. K., Uno, S., and Shertzer, H. G. (2002) Free Rad. Biol. Med., 33, 1268–1278.

    Article  CAS  PubMed  Google Scholar 

  119. Moennikes, O., Loeppen, S., Buchmann, A., Andersson, P., Ittrich, C., Poellinger, L., and Schwarz, M. (2004) Cancer Res., 64, 4707–4710.

    Article  CAS  PubMed  Google Scholar 

  120. Andersson, P., Rubio, C., Poellinger, L., and Hanberg, A. (2005) Anticancer Res., 25, 903–911.

    CAS  PubMed  Google Scholar 

  121. Traore, K., Sharma, R., Thimmulappa, R. K., Watson, W. H., Biswal, S., and Trush, M. A. (2008) J. Cell. Physiol., 216, 276–285.

    Article  CAS  PubMed  Google Scholar 

  122. Wang, Y., Biswas, G., Prabu, S. K, and Avadhani, N. G. (2006) Biochem. Pharmacol., 72, 881–892.

    Article  CAS  PubMed  Google Scholar 

  123. Fisher, M. T., Nagarkatti, M., and Nagarkatti, P. S. (2005) Toxicol. Lett., 157, 99–107.

    Article  CAS  PubMed  Google Scholar 

  124. Shen, D., Dalton, T. P., Nebert, D. W., and Shertzer, H. G. (2005) J. Biol. Chem., 280, 25305–25312.

    Article  CAS  PubMed  Google Scholar 

  125. Elsa, C., Jiang, C., Peshavariya, H. M., and Dusting, G. (2009) Pharmacol. Therap., 122, 97–108.

    Article  CAS  Google Scholar 

  126. Lambeth, D. J. (2007) Free Rad. Biol. Med., 43, 332–347.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Kashirskoe Shosse 24, 115478, Moscow, Russia

    V. A. Kobliakov

Authors
  1. V. A. Kobliakov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to V. A. Kobliakov.

Additional information

Original Russian Text © V. A. Kobliakov, 2010, published in Biokhimiya, 2010, Vol. 75, No. 6, pp. 757–769.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kobliakov, V.A. Mechanisms of tumor promotion by reactive oxygen species. Biochemistry Moscow 75, 675–685 (2010). https://doi.org/10.1134/S0006297910060015

Download citation

  • Received:

  • Revised:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0006297910060015

Key words

Search

Navigation