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Evolution of DNA polymerase ι structure and function in eukaryotes

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Abstract

Analysis of DNA polymerase ι (Pol ι) enzymic activity in different classes of eukaryotes has shown that error-prone activity of this enzyme can be found only in mammals, and that it is completely absent from organisms that are at lower stages of development. It was supposed that the emergence of the error-prone Pol ι activity in mammals is caused by structural alteration of the active center. Possible functions of error-prone Pol ι in higher eukaryotes are discussed.

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Authors and Affiliations

  1. Institute of Molecular Genetics, Russian Academy of Sciences, pl. Kurchatova 2, 123182, Moscow, Russia

    A. V. Makarova, V. Z. Tarantul & L. V. Gening

Authors
  1. A. V. Makarova
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  2. V. Z. Tarantul
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  3. L. V. Gening
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Correspondence to A. V. Makarova.

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Original Russian Text © A. V. Makarova, V. Z. Tarantul, L. V. Gening, 2008, published in Biokhimiya, 2008, Vol. 73, No. 3, pp. 426–433.

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Makarova, A.V., Tarantul, V.Z. & Gening, L.V. Evolution of DNA polymerase ι structure and function in eukaryotes. Biochemistry Moscow 73, 346–352 (2008). https://doi.org/10.1134/S0006297908030176

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  • DOI: https://doi.org/10.1134/S0006297908030176

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