Skip to main content
SpringerLink
Log in

Signal and regulatory effects of methylglyoxal in eukaryotic cells (review)

  • Published:
Applied Biochemistry and Microbiology Aims and scope Submit manuscript

    We’re sorry, something doesn't seem to be working properly.

    Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

Abstract

Methylglyoxal (MG) is one of the physiological glucose metabolites formed in living organisms. The data on the influence of MG on different internal systems of eukaryotic cells, including the central signaling pathways, are been discussed in the review. The central signaling pathways are stress-activated and sensitive to the action of reactive oxygen species. Integration of the literary data and authors’ results has allowed the conclusion that MG action on cells is multidirectional and is determined by its concentration and the physiological state of the cell. The cellular reaction upon increasing MG concentrations has a phase pattern and can be described by the hormesis concept. It has been hypothesized that MG participates in the formation of the braking regulatory circuit, which modulates the sensitivity of hypothalamus neurons to glucose. It is concluded that MG has a possible role in the functioning of the great biological clock. We propose that the data discussed in this review allow methylglyoxal to be considered a molecule with signal and regulatory functions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Thornalley, P.J., Gen. Pharmacol., 1996, vol. 27, no. 4, pp. 565–573.

    Article  CAS  PubMed  Google Scholar 

  2. Thornalley, P.J., Ann. N.Y. Acad. Sci., 2005, vol. 1043, pp. 111–117.

    Article  CAS  PubMed  Google Scholar 

  3. Zeng, J. and Davies, M.J., Chem. Res. Toxicol., 2005, vol. 18, no. 8, pp. 1232–1241.

    Article  CAS  PubMed  Google Scholar 

  4. Golubev, A.G., Biokhimiya, 1996, vol. 61, no. 11, pp. 2018–2039.

    CAS  Google Scholar 

  5. Golubev, A.G., Biologiya prodolzhitel’nosti zhizni i stareniya (Biology of Life Expectancy and Aging), St. Petersburg Izd. N-L, 2015.

    Google Scholar 

  6. Skulachev, V.P., Skulachev, M.V., and Fenyuk, B.A., Zhizn’ bez starosti (Life without Senility), Moscow Eksmo, 2014.

    Google Scholar 

  7. Davydov, V.V. and Bozhkov, A.I., Biomed. Khim., 2003, vol. 49, no. 4, pp. 374–387.

    CAS  PubMed  Google Scholar 

  8. Richard, J.P., Biochem. Soc. Trans., 1993, vol. 21, no. 2, pp. 549–553.

    Article  CAS  PubMed  Google Scholar 

  9. Kalapos, M.P., Drug Metabol. Drug Interact., 2008, vol. 23, nos. 1–2, pp. 69–91.

    CAS  PubMed  Google Scholar 

  10. Dutra, F., Knudsen, F.S., Curi, D., and Bechara, E.J.H., Chem. Res. Toxicol., 2001, vol. 14, no. 9, pp. 1323–1329.

    Article  CAS  PubMed  Google Scholar 

  11. Abordo, E.A., Harjit, S.M., and Thornalley, P.J., Biochem. Pharmacol., 1999, vol. 58, pp. 641–648.

    Article  CAS  PubMed  Google Scholar 

  12. Kalapos, M.P., Toxicol. Lett., 1999, vol. 110, no. 3, pp. 145–175.

    Article  CAS  PubMed  Google Scholar 

  13. Thornalley, P.J., Drug Metabol. Drug Interact., 2008, vol. 23, nos 1-2, pp. 125–150.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Angeloni, C., Zambonin, L., and Hrelia, S., Biomed. Res. Int., 2014, vol. 2014. doi 10.1155/2014/238485

  15. Maessen, D.E., Stehouwer, C.D., and Schalkwijk, C.G., Clin. Sci. (Lond.), 2015, vol. 28, no. 12, pp. 839–861.

    Article  CAS  Google Scholar 

  16. Koch, W.F., A Brief History of the Development of the Koch Synthetic Antitoxins. Reprinted in part from the Journal of the American Association for Medico-Physical Research, Detroit Koch Laboratories, 1941.

    Google Scholar 

  17. Szent-Gyorgyi, A., Science, 1965, vol. 149, no. 3679, pp. 34–37.

    Article  Google Scholar 

  18. Egyud, L.G. and Szent-Gyorgyi, A., Proc. Natl. Acad. Sci. U. S. A., 1966, vol. 56, no. 1, pp. 203–207.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Szent-Gyorgyi, A., Egyud, L.G., and McLaughlin, J.A., Science, 1967, vol. 155, no. 3762, pp. 539–541.

    Article  CAS  PubMed  Google Scholar 

  20. Liu, B.F., Miyata, S., Hirota, Y., Higo, S., Miyazaki, H., Fukunaga, M., Hamada, Y., Ueyama, S., Muramoto, O., Uriuhara, A., and Kasuga, M., Kidney Int., 2003, vol. 63, no. 3, pp. 947–957.

    Article  CAS  PubMed  Google Scholar 

  21. Fukunaga, M., Miyata, S., Higo, S., Hamada, Y., Ueyama, S., and Kasuga, M., Ann. N.Y. Acad. Sci., 2005, vol. 1043, pp. 151–157.

    Article  CAS  PubMed  Google Scholar 

  22. Portero-Otin, M., Pamplona, R., Bellmunt, M.J., Ruiz, M.C., Prat, J., Salvayre, R., and Negre-Salvayre, A., Diabetes, 2002, vol. 51, no. 5, pp. 1535–1542.

    Article  CAS  PubMed  Google Scholar 

  23. Liu, Y., Qu, Y., Wang, R., Ma, Y., Xia, C., Gao, C., Liu, J., Lian, K., Xu, A., Lu, X., Sun, L., Yang, L., Lau, W.B., Gao, E., Koch, W., Wang, H., and Tao, L., Am. J. Physiol. Endocrinol. Metab., 2012, vol. 303, no. 7, pp. 841–852.

    Article  CAS  Google Scholar 

  24. Riboulet-Chavey, A., Pierron, A., Durand, I., Murdaca, J., Giudicelli, J., and van Obberghen, E., Diabetes, 2006, vol. 55, no. 5, pp. 1289–1299.

    Article  CAS  PubMed  Google Scholar 

  25. Fiory, F., Lombardi, A., Miele, C., Giudicelli, J., Beguinot, F., and van Obberghen, E., Diabetologia, 2011, vol. 54, no. 11, pp. 2941–2952.

    Article  CAS  PubMed  Google Scholar 

  26. Yim, H.S., Kang, S.O., Hah, Y.C., Chock, P.B., and Yim, M.B., J. Biol. Chem., 1995, vol. 270, no. 47, pp. 28228–28233.

    Article  CAS  PubMed  Google Scholar 

  27. Goldin, A., Beckman, J.A., Schmidt, A.M., and Creager, M.A., Circulation, 2006, vol. 114, no. 6, p. 597.

    Article  CAS  PubMed  Google Scholar 

  28. Pun, P.B.L. and Murphy, M.P., Int. J. Cell Biol., 2012. doi 10.1155/2012/843505

    Google Scholar 

  29. Vistoli, G., de Maddis, D., Cipak, A., Zarkovic, N., Carini, M., and Aldin, G., Free Radic. Res., 2013, vol. 47, no. 1, pp. 3–27.

    Article  CAS  PubMed  Google Scholar 

  30. Nowotny, K., Jung, T., Grune, T., and Hohn, A., Exp. Gerontol., 2014, vol. 57, pp. 122–131.

    Article  CAS  PubMed  Google Scholar 

  31. Bourajjaj, M., Stehouwer, C.D.A., van Hinsbergh, V.W.M., and Schalkwijk, C.G., Biochem. Soc. Transact., 2003, vol. 31, no. 6, p. 1400.

    Article  CAS  Google Scholar 

  32. Vasdev, S. and Stuckless, J., J. Angiol., 2010, vol. 19, no. 1, pp. 58–65.

    Google Scholar 

  33. Ott, C., Jacobs, K., Haucke, E., Santos, A.N., Grune, T., and Simm, A., Redox Biol., 2014, vol. 2, no. 1, pp. 411–429.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Cantero, A.V., Portero-Otin, M., Ayala, V., Auge, N., Sanson, M., Elbaz, M., Thiers, J.C., Pamplona, R., Salvayre, R., and Negre-Salvayre, A., FASEB J., 2007, vol. 21, no. 12, pp. 3096–3106.

  35. Li, X.H., Xie, J.Z., Jiang, X., Lv, B.L., Cheng, X.S., Du, L.L., Zhang, J.Y., Wang, J.Z., and Zhou, X.W., Neuromol. Med., 2012, vol. 14, no. 4, pp. 338–348.

    Article  CAS  Google Scholar 

  36. Suravajjala, S., Cohenford, M., Frost, L.R., Pampati, P.K., and Dain, J.A., Clin. Chem. Acta, 2013, vol. 421, pp. 170–176.

    Article  CAS  Google Scholar 

  37. Lankin, V.Z., Konovalova, G.G., Tikhaze, A.K., Shumaev, K.B., Belova-Kumskova, E.M., Grechnikova, M.A., and Viigimaa, M., J. Diabetes, 2016, vol. 8, no. 3, pp. 398–404.

    Article  CAS  PubMed  Google Scholar 

  38. Rosca, M.G., Mustad, T.G., Kinter, M.T., Ozdemir, A.M., Kern, T.S., Szweda, L.I., Brownlee, M., Monnier, V.M., and Weiss, M.F., Am. J. Physiol.–Renal, 2005, vol. 289, no. 3, pp. 420–430.

    Article  CAS  Google Scholar 

  39. Uribarri, J., Cai, W., Peppa, M., Goodman, S., Ferrucci, L., Striker, G., and Vlassara, H., J. Gerontol. A Biol. Sci. Med. Sci., 2007, vol. 62, no. 4, pp. 427–433.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Desai, K.M. and Wu, L., Drug Metabol. Drug Interact., 2008, vol. 23, nos. 1–2, pp. 151–173.

    Article  CAS  PubMed  Google Scholar 

  41. Shumaev, K.B., Gubkina, S.A., Kumskova, E.M., Shepelkova, G.S., Ruuge, E.K., and Lankin, V.Z., Biochemistry (Moscow), 2009, vol. 74, no. 4., pp. 461–466.

    Article  CAS  Google Scholar 

  42. Kosmachevskaya, O.V., Shumaev, K.B., Nasybullina, E.I., Gubkina, S., and Topunov, A.F., Hemoglobin, 2013, vol. 37, no. 3, pp. 205–218.

    Article  CAS  PubMed  Google Scholar 

  43. Kosmachevskaya, O.V., Shumaev, K.B., Nasybullina, E.I., and Topunov, A.F., Clin. Chem. Lab. Med., 2014, vol. 52, no. 1, pp. 161–168.

    Article  CAS  PubMed  Google Scholar 

  44. Wu, L. and Juurlink, B.H., Hypertension, 2002, vol. 39, no. 3, pp. 809–814.

    Article  CAS  PubMed  Google Scholar 

  45. Wu, L., Can. J. Physiol. Pharmacol., 2005, vol. 83, no. 1, pp. 63–68.

    Article  CAS  PubMed  Google Scholar 

  46. Ramasamy, R., Vannucci, S.J., Yan, S.S., Herold, K., Yan, S.F., and Schmidt, A.M., Glycobiology, 2005, vol. 15, no. 7, pp. 16–28.

    Article  CAS  Google Scholar 

  47. Hsuuw, Y.D., Chang, C.K., Chan, W.H., and Yu, J.S., J. Cell Physiol., 2005, vol. 205, no. 3, pp. 379–386.

    Article  CAS  PubMed  Google Scholar 

  48. Ho, C., Lee, P.H., Huang, W.J., Hsu, Y.C., Lin, C.L., and Wang, J.Y., Nephrology (Carlton), 2007, vol. 12, no. 4, pp. 348–356.

    Article  CAS  Google Scholar 

  49. Matsuo, J., Oku, H., Kanbara, Y., Kobayashi, T., Sugiyama, T., and Ikeda, T., Exp. Eye Res., 2009, vol. 89, no. 5, pp. 693–699.

    Article  CAS  PubMed  Google Scholar 

  50. Guo, Y., Lu, M., Qian, J., and Cheng, Y.-L., J. Gerontol., 2009, vol. 64A, no. 6, pp. 629–635.

    Article  CAS  Google Scholar 

  51. Lee, C., Yim, M.B., Chock, P.B., Yim, H.S., and Kang, S.O., J. Biol. Chem., 1998, vol. 273, no. 39, pp. 25272–25278.

    Article  CAS  PubMed  Google Scholar 

  52. Brouwers, O., Niessen, P.M., Haenen, G., Miyata, T., Brownlee, M., Stehouwer, C.D., de Mey, J.G., and Schalkwijk, C.G., Diabetologia, 2010, vol. 53, no. 5, pp. 989–1000.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. Dhar, A., Dhar, I., Desai, K.M., and Wu, L., British J. Pharmacol., 2010, vol. 161, no. 8, pp. 1843–1856.

  54. Su, Y., Qadri, S.M., Hossain, M., Wu, L., and Liu, L., Biochem. Pharmacol., 2013, vol. 86, no. 12, pp. 1762–1774.

    Article  CAS  PubMed  Google Scholar 

  55. Rojas, A., Romay, S., Gonzalez, D., Herrera, B., Delgado, R., and Otero, K., Circ. Res., 2000, vol. 86, no. 3, pp. 50–54.

    Article  Google Scholar 

  56. Brouwers, O., Teerlink, T., van Bezu, J., Barto, R., Stehouwer, C., and Schalkwijk, C., Ann. N.Y. Acad. Sci., 2008, vol. 1126, pp. 231–234.

    Article  CAS  PubMed  Google Scholar 

  57. Chang, T., Wang, R., and Wu, L., Free Radic. Biol. Med., 2005, vol. 38, no. 2, pp. 286–293.

    Article  CAS  PubMed  Google Scholar 

  58. Kobayashi, T., Oku, H., Komori, A., Okuno, T., Kojima, S., Obayashi, H., Sugiyama, T., Hasegawa, G., Fukui, M., Nakamura, N., and Ikeda, T., Exp. Eye Res., 2005, vol. 81, no. 6, pp. 647–654.

    Article  CAS  PubMed  Google Scholar 

  59. Pacher, P., Beckman, J.S., and Liaudet, L., Physiol Rev., 2007, vol. 87, no. 1, pp. 315–424.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  60. Massari, J., Tokikawa, R., Zanolli, L., Tavares, M.F.M., Assuncao, N.A., and Bechara, E.J.H., Chem. Res. Toxicol., 2010, vol. 23, no. 11, pp. 1762–1770.

    Article  CAS  PubMed  Google Scholar 

  61. Shumaev, K.B., Gubkina, S.A., Vanin, A.F., Burbaev, D.Sh., Mokh, V.P., Topunov, A.F., and Ruuge, E.K., Biophysics, 2013, vol. 58, no. 2, pp. 172–177.

    Article  CAS  Google Scholar 

  62. Shumaev, K.B., Kosmachevskaya, O.V., Nasybullina, E.I., Gromov, S.V., Novikov, A.A., and Topunov, A.F., J. Biol. Inorg. Chem., 2017, vol. 22, no. 1, pp. 153–160.

    Article  CAS  PubMed  Google Scholar 

  63. Halder, J., Ray, M., and Ray, S., Int. J. Cancer, 1993, vol. 54, no. 3, pp. 443–449.

    Article  CAS  PubMed  Google Scholar 

  64. Ray, S., Dutta, S., Halder, J., and Ray, M., Biochem. J., 1994, vol. 303, no. 11, pp. 69–72.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  65. Biswas, S., Ray, M., Misra, S., Dutta, D.P., and Ray, S., Biochem. J., 1997, vol. 323, no. 2, pp. 343–348.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  66. Wang, H., Liu, J., and Wu, L., Biochem. Pharmacol., 2009, vol. 77, no. 11, pp. 1709–1716.

    Article  CAS  PubMed  Google Scholar 

  67. Suh, K.S., Choi, E.M., Rhee, S.Y., and Kim, Y.S., Free Radical Res., 2014, vol. 48, no. 2, pp. 206–217.

    Article  CAS  Google Scholar 

  68. de Arriba, S.G., Krugel, U., Regenthal, R., Vissiennon, Z., Verdaguer, E., Lewerenz, A., Garcia-Jorda, E., Pallas, M., Camins, A., Munch, G., Nieber, K., and Allgaier, C., Free Radic. Biol. Med., 2006, vol. 40, no. 5, pp. 779–790.

    Article  PubMed  CAS  Google Scholar 

  69. de Arriba, S.G., Stuchbury, G., Yarin, J., Burnell, J., Loske, C., and Munch, G., Neurobiol. Aging, 2007, vol. 28, no. 7, pp. 1044–1050.

    Article  PubMed  CAS  Google Scholar 

  70. Okouchi, M., Okayama, N., and Aw, T.Y., Curr. Neurovasc. Res., 2005, vol. 2, no. 1, pp. 13–22.

    Article  CAS  PubMed  Google Scholar 

  71. Seo, K., Ki, S.H., and Shin, S.M., Toxicol. Res., 2014, vol. 30, no. 3, pp. 193–198.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  72. Hipkiss, A.R., Biogerontology, 2008, vol. 9, no. 1, pp. 49–55.

    Article  CAS  PubMed  Google Scholar 

  73. Hipkiss, A.R., Front. Aging Neurosci., 2010, vol. 2. doi 10.3389/fnagi.2010.00010

  74. Brownlee, M., Nature, 2001, vol. 414, no. 6865, pp. 813–820.

    Article  CAS  PubMed  Google Scholar 

  75. Bulteau, A.L., Lundberg, K.C., Ikeda-Saito, M., Isaya, G., and Szweda, L.I., Proc. Natl. Acad. Sci. U. S. A., 2005, vol. 102, no. 17, pp. 5987–5991.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  76. Leoncini, G., Maresca, M., and Buzzi, E., Cell Biochem. Funct., 1989, vol. 7, no. 1, pp. 65–70.

    Article  CAS  PubMed  Google Scholar 

  77. Stein, J., Milewski, W.M., Hara, M., Steiner, D.F., and Dey, A., Islets, 2011, vol. 3, no. 1, pp. 21–34.

    Article  PubMed  PubMed Central  Google Scholar 

  78. Nikoulina, S.E., Ciaraldi, T.P., Mudaliar, S., Mohideen, P., Carter, L., and Henry, R.R., Diabetes, 2000, vol. 49, no. 2, pp. 263–271.

    Article  CAS  PubMed  Google Scholar 

  79. Chang, T., Wang, R., Olson, D.J., Mousseau, D.D., Ross, A.R., and Wu, L., FASEB J., 2011, vol. 25, no. 5, pp. 1746–1757.

  80. Tanabe, K., Liu, Z., Patel, S., Doble, B.W., Li, L., Cras-Meneur, C., Martinez, S.C., Welling, C.M., White, M.F., Bernal-Mizrachi, E., Woodgett, J.R., and Permutt, M.A., PLoS Biol., 2008, vol. 6, no. 2, p. e37. doi 10.1371/journal.pbio.0060037

    Google Scholar 

  81. Sweeney, G., Somwar, R., Ramlal, T., Volchuk, A., Ueyama, A., Klip, A.J., J. Biol. Chem., 1999, vol. 274, no. 15, pp. 10071–10078.

    Article  CAS  PubMed  Google Scholar 

  82. Somwar, R., Niu, W., Kim, D.Y., Sweeney, G., Randhawa, V.K., Huang, C., Ramlal, T., and Klip, A., J. Biol. Chem., 2001, vol. 276, no. 49, pp. 46079–46087.

    Article  CAS  PubMed  Google Scholar 

  83. Carlson, C.J., Koterski, S., Sciotti, R.J., Poccard, G.B., and Rondinone, C.M., Diabetes, 2003, vol. 52, no. 3, pp. 634–641.

    Article  CAS  PubMed  Google Scholar 

  84. Dhar, A., Dhar, I., Jiang, B., Desai, K.M., and Wu, L., Diabetes, 2011, vol. 60, no. 3, pp. 899–908.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  85. Higa, A. and Chevet, E., Cell Signal., 2012, vol. 24, no. 8, pp. 1548–1555.

    Article  CAS  PubMed  Google Scholar 

  86. Palsamy, P., Bidasee, K.R., Ayaki, M., Augusteyn, R.C., Chan, J.Y., and Shinohara, T., Free Radic. Biol. Med., 2014, vol. 72, pp. 134–148.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  87. Mesitov, M.V., Ignashkova, T.I., Meshcherskii, M.E., Akopov, A.S., Sokolovskaya, A.A., Moskovtsev, A., and Kubatiev, A.A., Patol. Fiziol. Eksp. Terap., 2012, vol. 3, no. 3, pp. 87–93.

    Google Scholar 

  88. Kuntz, S., Rudloff, S., Ehl, J., Bretzel, R.G., and Kunz, C., Eur. J. Nutr., 2009, vol. 48, no. 8, pp. 499–503.

    Article  CAS  PubMed  Google Scholar 

  89. Kuntz, S., Kunz, C., and Rudloff, S., Mol. Nutr. Food Res., 2010, vol. 54, no. 10, pp. 1458–1467.

    Article  CAS  PubMed  Google Scholar 

  90. Akhand, A.A., Hossain, K., Mitsui, H., Kato, M., Miyata, T., Inagi, R., Du, J., Takeda, K., Kawamoto, Y., Suzuki, H., Kurokawa, K., and Nakashima, I., Free Radic. Biol. Med., 2001, vol. 31, no. 1, pp. 20–30.

    Article  CAS  PubMed  Google Scholar 

  91. Akhand, A.A., Hossain, K., Kato, M., Miyata, T., Du, J., Suzuki, H., Kurokawa, K., and Nakashima, I., Free Radic. Biol. Med., 2001, vol. 31, no. 10, pp. 1228–1235.

    Article  CAS  PubMed  Google Scholar 

  92. Du, J., Cai, S., Suzuki, H., Akhand, A.A., Ma, X., Takagi, Y., Miyata, T., Nakashima, I., and Nagase, F., J. Cell. Biochem., 2003, vol. 88, no. 6, pp. 1235–1246.

    Article  CAS  PubMed  Google Scholar 

  93. Wang, H., Meng, Q.H., Gordon, J.R., Khandwala, H., and Wu, L., Clin. Biochem, 2007, vol. 40, nos. 16–17, pp. 1232–1239.

    Article  CAS  PubMed  Google Scholar 

  94. Yamawaki, H. and Hara, Y., Biochem. Biophys. Res. Commun., 2008, vol. 369, no. 4, pp. 1155–1159.

    Article  CAS  PubMed  Google Scholar 

  95. Yamawaki, H., Saito, K., Okada, M., and Hara, Y., Am. J. Physiol. Cell Physiol., 2008, vol. 295, no. 6, pp. 1510–1517.

    Article  CAS  Google Scholar 

  96. Tikellis, C., Pickering, R.J., Tsorotes, D., Huet, O., Cooper, M.E., Jandeleit-Dahm, K., and Thomas, M.C., Diabetes, 2014, vol. 63, no. 11, pp. 3915–3925.

    Article  CAS  PubMed  Google Scholar 

  97. Webster, L., Abordo, E.A., Thornalley, P.J., and Limb, G.A., Biochem. Soc. Trans., 1997, vol. 25, no. 2, p. 250.

    Article  Google Scholar 

  98. Su, Y., Qadri, S.M., Cayabyab, F.S., Wu, L., and Liu, L., Biochim. Biophys. Acta, 2014, vol. 1843, no. 11, pp. 2481–2491.

    Article  CAS  PubMed  Google Scholar 

  99. Qadri, S.M., Su, Y., Cayabyab, F.S., and Liu, L., Cardiovasc. Diabetol., 2014, vol. 13. doi 10.1186/s12933- 014-0134-7

  100. Wakabayashi, S., Hisamitsu, T., and Nakamura, T.Y., J. Mol. Cell Cardiol., 2013, vol. 61, pp. 68–76. doi 10.1016/j.yjmcc.2013.02.007

    Article  CAS  PubMed  Google Scholar 

  101. Jandeleit-Dahm, K., Hannan, K.M., Farrelly, C.A., Allen, T.J., Rumble, J.R., Gilbert, R.E., Cooper, M.E., and Little, P.J., Circ. Res., 2000, vol. 87, no. 12, pp. 1133–1140.

    Article  CAS  PubMed  Google Scholar 

  102. Uriuhara, A., Miyata, S., Liu, B-F., Miyazaki, H., Kusunoki, H., Kojima, H., Yamashita, Y., Suzuki, K., Inaba, K., and Kasuga, M., Kobe J. Med. Sci., 2007, vol. 53, no. 6, p. 305.

    CAS  Google Scholar 

  103. Itoh, K., Mimura, J., and Yamamoto, M., Antioxid. Redox Signal., 2010, vol. 13, no. 11, pp. 1665–1678.

    Article  CAS  PubMed  Google Scholar 

  104. Turpaev, K.T., Biochemistry (Moscow), 2013, vol. 78, no. 2, pp. 111–126.

    Article  CAS  Google Scholar 

  105. Zenkov, N.K., Menshchikova, E.B., and Tkachev, V.O., Biochemistry (Moscow), 2013, vol. 78, no. 1, pp. 19–36.

    Article  CAS  Google Scholar 

  106. Xue, M., Rabbani, N., Momiji, H., Imbasi, P., Anwar, M.M., Kitteringham, N., Park, B.K., Souma, T., Moriguchi, T., Yamamoto, M., and Thornalley, P.J., Biochem. J., 2012, vol. 443, no. 1, pp. 213–222.

    Article  CAS  PubMed  Google Scholar 

  107. Sato, K., Tatsunami, R., Yama, K., Murao, Y., and Tampo, Y., Toxicol. Rep., 2015, vol. 2, pp. 1454–1462.

    Article  CAS  Google Scholar 

  108. Takizawa, N., Takada, K., and Ohkawa, K., Biochem. Biophys. Res. Commun., 1993, vol. 192, no. 2, pp. 700–706.

    Article  CAS  PubMed  Google Scholar 

  109. Colzani, M., Criscuolo, A., Casali, G., Carini, M., and Aldini, G., Free Radic. Res., 2016, vol. 50, no. 3, pp. 328–336.

    Article  CAS  PubMed  Google Scholar 

  110. Moheimani, F., Morgan, P.E., van Reyk, D.M., and Davies, M.J., Biochim. Biophys. Acta, 2010, vol. 1802, no. 6, pp. 561–571.

    Article  CAS  PubMed  Google Scholar 

  111. Queisser, M.A., Yao, D., Geisler, S., Hammes, H.P., Lochnit, G., Schleicher, E.D., Brownlee, M., and Preissner, K.T., Diabetes, 2010, vol. 59, no. 3, pp. 670–678.

    Article  CAS  PubMed  Google Scholar 

  112. Du, J., Zeng, J., Ou, X., Ren, X., and Cai, S., Int. J. Biochem. Cell. Biol., 2006, vol. 38, no. 7, pp. 1084–1091.

    Article  CAS  PubMed  Google Scholar 

  113. Bento, C.F., Fernandes, R., Ramalho, J., Marques, C., Shang, F., Taylor, A., and Pereira, P., PLoS One, 2010, vol. 5, p. e15062. doi 10.1371/journal.pone.0015062

  114. Roy, A., Hashmi, S., Li, Z., Dement, A.D., Cho, K.H., and Kim, J.-H., Mol. Biol. Cell, 2016, vol. 27, no. 5, pp. 862–871.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  115. Chang, Y.C., Hsieh, M.C., Wu, H.J., Wu, W.C., and Kao, Y.H., Toxicol. in Vitro, 2015, vol. 29, no. 7, pp. 1358–1368.

    Article  CAS  PubMed  Google Scholar 

  116. Fang, L., Li, X., Zhong, Y., Yu, J., and Dai, H., J. Neurochem., 2015, vol. 135, no. 2, pp. 431–440.

    Article  CAS  PubMed  Google Scholar 

  117. Jan, C.R., Chen, C.H., Wang, S.C., and Kuo, S.Y., Cell. Signal., 2005, vol. 17, no. 7, pp. 847–855.

    Article  CAS  PubMed  Google Scholar 

  118. Kuhla, B., Luth, H.J., Haferburg, D., Weick, M., Reichenbach, A., Arendt, T., and Munch, G., J. Neurosci. Res., 2006, vol. 83, no. 8, pp. 1591–1600.

    Article  CAS  PubMed  Google Scholar 

  119. Chan, W.H. and Wu, H.J., J. Cell. Biochem., 2008, vol. 103, no. 4, pp. 1144–1157.

    Article  CAS  PubMed  Google Scholar 

  120. Radu, B.M., Dumitrescu, D.I., Mustaciosu, C.C., and Radu, M., Cell. Mol. Neurobiol., 2012, vol. 32, no. 6, pp. 1047–1057.

    Article  CAS  PubMed  Google Scholar 

  121. Maeta, K., Izawa, S., and Inoue, Y., J. Biol. Chem., 2005, vol. 280, no. 1, pp. 253–260.

    Article  CAS  PubMed  Google Scholar 

  122. Koivisto, A., Hukkanen, M., Saarnilehto, M., Chapman, H., Kuokkanen, K., Wei, H., Viisanen, H., Akerman, K.E., Lindstedt, K., and Pertovaara, A., Pharmacol. Res., 2012, vol. 65, no. 1, pp. 149–158.

    Article  CAS  PubMed  Google Scholar 

  123. Andersson, D.A., Gentry, C., Light, E., Vastani, N., Vallortigara, J., Bierhaus, A., Fleming, T., and Bevan, S., PLoS One, 2013, vol. 8, p. e77986. doi 10.1371/journal.pone.0077986

  124. Oguri, G., Nakajima, T., Yamamoto, Y., Takano, N., Tanaka, T., Kikuchi, H., Morita, T., Nakamura, F., Yamasoba, T., and Komuro, I., Am. J. Physiol. Heart Circ. Physiol., 2014, vol. 307, no. 9, pp. 1339–1352.

    Article  CAS  Google Scholar 

  125. Yang, Y., Konduru, A.S., Cui, N., Yu, L., Trower, T.C., Shi, W., Shi, Y., and Jiang, C., Acta Pharmacol. Sin., 2014, vol. 35, no. 1, pp. 58–64.

    Article  CAS  PubMed  Google Scholar 

  126. Mukohda, M., Yamawaki, H., Nomura, H., Okada, M., and Hara, Y., J. Pharmacol. Sci., 2009, vol. 109, no. 2, pp. 305–310.

    Article  CAS  PubMed  Google Scholar 

  127. Bierhaus, A., Fleming, T., Stoyanov, S., Leffler, A., Babes, A., Neacsu, C., Sauer, S.K., Eberhardt, M., Schnölzer, M., Lasitschka, F., Neuhuber, W.L., Kichko, T.I., Konrade, I., Elvert, R., Mier, W., Pirags, V., Lukic, I.K., Morcos, M., Dehmer, T., Rabbani, N., Thornalley, P.J., Edelstein, D., Nau, C., Forbes, J., Humpert, P.M., Schwaninger, M., Ziegler, D., Stern, D.M., Cooper, M.E., Haberkorn, U., Brownlee, M., Reeh, P.W., and Nawroth, P.P., Nat. Med., 2012, vol. 18, no. 6, pp. 926–933.

    Article  CAS  PubMed  Google Scholar 

  128. Hambsch, B., Chen, B.G., Brenndorfer, J., Meyer, M., Avrabos, C., Maccarrone, G., Maccarrone, G., Liu, R.H., Eder, M., Turck, C.W., and Landgraf, R., J. Neurochem., 2010, vol. 113, no. 5, pp. 1240–1251.

    CAS  PubMed  Google Scholar 

  129. Distler, M.G. and Palmer, A.A., Front. Genet., 2012, vol. 3, p. e250. doi 10.3389/fgene.2012.00250

  130. Xie, B., Lin, F., Peng, L., Ullah, K., Wu, H., Qing, H., and Deng, Y., Acta Biochim. Biophys. Sin. (Shanghai), 2014, vol. 46, no. 11, pp. 950–956.

    Article  CAS  Google Scholar 

  131. Li, D., Ma, S., and Ellis, E.M., Chem.-Biol. Interact., 2015, vol. 234, pp. 366–371.

    Article  CAS  PubMed  Google Scholar 

  132. Dafre, A.L., Goldberg, J., Wang, T., Spiegel, D.A., and Maher, P., Free Radic. Biol. Med., 2015, vol. 89, pp. 8–19. doi 10.1016/j.freeradbiomed.2015.07.005

    Article  CAS  PubMed  Google Scholar 

  133. Nomura, W., Maeta, K., Kita, K., Izawa, S., and Inoue, Y., Appl. Microbiol. Biotechnol., 2010, vol. 86, no. 6, pp. 1887–1894.

    Article  CAS  PubMed  Google Scholar 

  134. Galligan, J.J., Mitchener, M.M., Wauchope, O.R., Wang, T., Rose, K.L., Spiegel, D.A., and Marnett, L.J., FASEB J., 2016, vol. 30 (suppl.), abstract 586.2.

  135. Rajasekar, P., O’Neill, C.L., Eeles, L., Stitt, A.W., and Medina, R.J., J. Diabetes Res., 2015, vol. 2015, p. e436879. doi 10.1155/2015/436879

  136. Mir, A.R., Uddin, M., Khan, F., Alam, K., and Ali, A., PLoS One, 2015, vol. 10, p. e0136197. doi 10.1371/journal. pone.0136197

  137. Mir, A.R., Moinuddin, HabibS., Khan, F., Alam, K., and Ali, A., Glycobiology, 2016, vol. 26, no. 2, pp. 129–141.

    Article  CAS  PubMed  Google Scholar 

  138. Jia, X. and Wu, L., Mol. Cell. Biochem., 2007, vol. 306, nos. 1–2, pp. 133–139.

    Article  CAS  PubMed  Google Scholar 

  139. Jia, X., Chang, T., Wilson, T.W., and Wu, L., PLoS One, 2012, vol. 7, p. e36610. doi 10.1371/journal. pone.0036610

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  140. Harper, J.W., Adami, G.R., Wei, N., Keyomarsi, K., and Elledge, S.J., Cell, 1993, vol. 75, no. 4, pp. 805–816.

    Article  CAS  PubMed  Google Scholar 

  141. Waskiewicz, A.J. and Cooper, J.A., Curr. Opin. Cell. Biol., 1995, vol. 7, no. 6, pp. 798–805.

    Article  CAS  PubMed  Google Scholar 

  142. Nokin, M.J., Durieux, F., Peixoto, P., Chiavarina, B., Peulen, O., Blomme, A., Turtoi, A., Costanza, B., Smargiasso, N., Baiwir, D., Scheijen, J.L., Schalkwijk, C.G., Leenders, J., de Tullio, P., Bianchi, E., Thiry, M., Uchida, K., Spiegel, D.A., Cochrane, J.R., Hutton, C.A., de Pauw, E., Delvenne, P., Belpomme, D., Castronovo, V., and Bellahcè ne, A., eLife, 2016, vol. 5, p. e19375. doi 10.7554/eLife.19375

  143. Di Loreto, S., Caracciolo, V., Colafarina, S., Sebastiani, P., Gasbarri, A., and Amicarelli, F., Brain Res., 2004, vol. 1006, no. 2, pp. 157–167.

    Article  PubMed  CAS  Google Scholar 

  144. Heimfarth, L., Loureiro, S.O., Pierozan, P., de Lima, B.O., Reis, K.P., Torres, E.B., and Pessoa-Pureur, R., Metab. Brain Dis., 2013, vol. 28, no. 3, pp. 429–438.

    Article  CAS  PubMed  Google Scholar 

  145. Huang, S.M., Hsu, C.L., Chuang, H.C., Shih, P.H., Wu, C.H., and Yen, G.C., Neurotoxicology, 2008, vol. 29, pp. 1016–102.

    Article  CAS  PubMed  Google Scholar 

  146. Huang, W.J., Tung, C.W., Ho, C., Yang, J.T., Chen, M.L., Chang, P.J., Lee, P.H., Lin, C.L., and Wang, J.Y., Ren. Fail., 2007, vol. 29, no. 7, pp. 911–921.

    Article  CAS  PubMed  Google Scholar 

  147. Kani, S., Nakayama, E., Yoda, A., Onishi, N., Sougawa, N., Hazaka, Y., Umeda, T., Takeda, K., Ichijo, H., Hamada, Y., and Minami, Y., Genes Cells, 2007, vol. 12, no. 8, pp. 919–928.

    Article  CAS  PubMed  Google Scholar 

  148. Li, G., Chang, M., Jiang, H., Xie, H., Dong, Z., and Hu, L., Cell Biochem. Funct., 2011, vol. 29, no. 1, pp. 30–35.

    Article  PubMed  CAS  Google Scholar 

  149. Kim, J., Son, J.W., Lee, J.A., Oh, Y.S., and Shinn, S.H., J. Korean. Med. Sci., 2004, vol. 19, no. 1, pp. 95–100.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  150. Kang, Y., Edwards, L.G., and Thornalley, P.J., Leukemia Res., 1996, vol. 20, pp. 397–405.

    Article  CAS  Google Scholar 

  151. Hsieh, M.S. and Chan, W.H., Int. J. Mol. Sci., 2009, vol. 10, no. 4, pp. 1445–1464.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  152. Du, J., Suzuki, H., Nagase, F., Akhand, A.A., Yokoyama, T., Miyata, T., Kurokawa, K., and Nakashima, I., J. Cell. Biochem., 2000, vol. 77, no. 2, pp. 333–344.

    Article  CAS  PubMed  Google Scholar 

  153. Okado, A., Kawassaki, Y., Hasuike, Y., Takahashi, M., Teshima, T., Fujii, J., and Taniguchi, N., Biochem. Biophys. Res. Commun., 1996, vol. 225, no. 1, pp. 219–224.

    Article  CAS  PubMed  Google Scholar 

  154. Gawlowski, T., Stratmann, B., Stirban, A.O., Negrean, M., and Tschoepe, D., Thromb Res., 2007, vol. 121, no. 1, pp. 117–126.

    Article  CAS  PubMed  Google Scholar 

  155. Figarola, J.L., Singhal, J., Rahbar, S., Awasthi, S., and Singhal, S.S., Apoptosis, 2014, vol. 19, no. 5, pp. 776–788.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  156. Kim, J., Kim, O.S., Kim, C.S., Sohn, E., Jo, K., and Kim, J.S., Exp. Mol. Med., 2012, vol. 44, no. 2, pp. 167–175.

    Article  PubMed  CAS  Google Scholar 

  157. Jeong, W.J., Rho, J.H., Yoon, Y.G., Yoo, S.H., Jeong, N.Y., Ryu, W.Y., Ahn, H.B., Park, W.C., Rho, S.H., Yoon, H.S., Choi, Y.H., and Yoo, Y.H., PLoS One, 2012, vol. 7, p. e45754. doi 10.1371/journal. pone.0045754

  158. Chen, J., Song, M., Yu, S., Gao, P., Yu, Y., Wang, H., and Huang, L., Mol. Cell. Biochem., 2010, vol. 335, nos. 1–2, pp. 137–146.

    Article  CAS  PubMed  Google Scholar 

  159. Lee, B.H., Hsu, W.H., Hsu, Y.W., and Pan, T.M., Free Radic. Biol. Med., 2013, vol. 60, pp. 7–16. doi 10.1016/ j.freeradbiomed.2013.01.030

    Article  CAS  PubMed  Google Scholar 

  160. Fan, X., Subramaniam, R., Weiss, M.F., and Monnier, V.M., Arch. Biochem. Biophys., 2003, vol. 4, no. 2, pp. 274–286.

    Article  Google Scholar 

  161. Pal, A., Bhattacharya, I., Bhattacharya, K., Mandal, C., and Ray, M., Mol. Immunol., 2009, vol. 46, no. 10, pp. 2039–2044.

    Article  CAS  PubMed  Google Scholar 

  162. Milanesa, D.M., Choudhury, M.S., Mallouh, C., Tazaki, H., and Konno, S., Eur. Urol., 2000, vol. 37, no. 6, pp. 728–734.

    Article  CAS  PubMed  Google Scholar 

  163. Nass, N., Bromme, H.-J., Hartig, R., Korkmaz, S., Sel, S., Hirche, F., Ward, A., Simm, A., Wiemann, S., Lykkesfeldt, A.E., Roessner, A., and Kalinski, T., PLoS One, 2014, vol. 9, p. e101473. doi 10.1371/journal. pone.0101473

  164. Belanger, M., Yang, J., Petit, J.M., Laroche, T., Magistretti, P.J., and Allaman, I., J. Neurosci., 2011, vol. 31, no. 50, pp. 18338–18352.

    Article  CAS  PubMed  Google Scholar 

  165. Lee, C.I., Perng, J.H., Chen, H.Y., Hong, Y.R., and Wang, J.J., J. Cell. Biochem., 2015, vol. 116, no. 9, pp. 2074–2085.

    Article  CAS  PubMed  Google Scholar 

  166. Együd, L.G. and Szent-Györgyi, A., Science, 1968, vol. 160, no. 3832, p. 1140.

    Article  PubMed  Google Scholar 

  167. Paul-Samojedny, M., Lasut, B., Pudelko, A., Fila-Danilow, A., Kowalczyk, M., Suchanek-Raif, R., Zielinski, M., Borkowska, P., and Kowalski, J., Biomed. Pharmacother., 2016, vol. 80, pp. 236–243. doi 10.1016/j.biopha.2016.03.021

    Article  CAS  PubMed  Google Scholar 

  168. Chakraborty, S., Karmakar, K., and Chakravortty, D., IUBMB Life, 2014, vol. 66, no. 10, pp. 667–678.

    Article  CAS  PubMed  Google Scholar 

  169. Ghosh, M., Talukdar, D., Ghosh, S., Bhattacharyya, N., Ray, M., and Ray, S., Toxicol. Appl. Pharmacol., 2006, vol. 212, no. 1, pp. 45–58.

    Article  CAS  PubMed  Google Scholar 

  170. Morgan, P.E., Dean, R.T., and Davies, M.J., Arch. Biochem. Biophys., 2002, vol. 403, no. 2, pp. 259–269.

    Article  CAS  PubMed  Google Scholar 

  171. Ghosh, S., Mukherjee, K., Ray, M., and Ray, S., Eur. J. Biochem., 2001, vol. 268, no. 23, pp. 6037–6044.

    Article  CAS  PubMed  Google Scholar 

  172. Ghosh, S., Ray, M., and Ray, S., Indian J. Biochem. Biophys., 2004, vol. 41, no. 1, pp. 7–13.

  173. Price, C.L., Hassi, H.O., English, N.R., Blakemore, A.I., Stagg, A.J., and Knight, S.C., J. Cell Mol. Med., 2010, vol. 14, no. 6B, pp. 1806–1815.

    CAS  PubMed  Google Scholar 

  174. Bhattacharyya, N., Pal, A., Patra, S., Haldar, A.K., Roy, S., and Ray, M., Int. Immunophar., 2008, vol. 8, no. 11, pp. 1503–1512.

    Article  CAS  Google Scholar 

  175. Geng, X., Ma, J., Zhang, F., and Xu, C., Oncol. Res. Treat., 2014, vol. 37, no. 10, pp. 570–574.

    Article  CAS  PubMed  Google Scholar 

  176. More, S.S. and Vince, R., J. Med. Chem., 2009, vol. 52, no. 15, pp. 4650–4656.

    Article  CAS  PubMed  Google Scholar 

  177. Zhang, H., Huang, Q., Zhai, J., Zhao, Y.N., Zhang, L.P., Chen, Y.Y., Zhang, R.W., Li, Q., and Hu, X.P., Acta Pharmacol. Sin., 2015, vol. 36, no. 9, pp. 1145–1150.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  178. Zhang, H., Zhai, J., Zhang, L., Li, C., Zhao, Y., Chen, Y., Li, Q., and Hu, X.P., Curr. Top. Med. Chem., 2016, vol. 16, no. 4, pp. 460–466.

    Article  CAS  PubMed  Google Scholar 

  179. Sang, Y., Shi, Q., Mo, M., Ni, C., Li, Z., Liu, B., Deng, Q., Creighton, D.J., and Zheng, Z.B., Bioorg. Med. Chem. Lett., 2015, vol. 25, no. 21, pp. 4724–4727.

    Article  CAS  PubMed  Google Scholar 

  180. Mihai, D.M., Hall, S., Deng, H., Welch, C.J., and Kawamura, A., Bioorg. Med. Chem. Lett., 2015, vol. 25, no. 22, pp. 5349–5351.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  181. Zuin, A., Vivancos, A.P., Sanso, M., Takatsume, Y., Ayte, J., Inoue, Y., and Hidalgo, E., J. Biol. Chem., 2005, vol. 280, no. 44, pp. 36708–36713.

    Article  CAS  PubMed  Google Scholar 

  182. Maeta, K., Izawa, S., Okazaki, S., Kuge, S., and Inoue, Y., Mol. Cell. Biol., 2004, vol. 24, no. 19, pp. 8753–8764.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  183. Takatsume, Y., Izawa, S., and Inoue, Y., J. Biol. Chem., 2006, vol. 281, no. 14, pp. 9086–9092.

    Article  CAS  PubMed  Google Scholar 

  184. Takatsume, Y., Izawa, S., and Inoue, Y., Biochem. Biophys. Res. Commun., 2007, vol. 363, no. 4, pp. 942–947.

    Article  CAS  PubMed  Google Scholar 

  185. Norbeck, J. and Blomberg, A., J. Biol. Chem., 1997, vol. 272, no. 9, pp. 5544–5554.

    Article  CAS  PubMed  Google Scholar 

  186. Aguilera, J. and Prieto, J.A., FEMS Yeast Res., vol. 4, no. 6, pp. 633–641.

  187. Aguilera, J., Rodriguez-Vargas, S., and Prieto, J.A., Mol. Microbiol., 2005, vol. 56, no. 1, pp. 228–239.

    Article  CAS  PubMed  Google Scholar 

  188. Aguilera, J. and Prieto, J.A., Curr. Genet., 2001, vol. 39, nos. 5–6, pp. 273–283.

    Article  CAS  PubMed  Google Scholar 

  189. Southam, C.M. and Ehrlich, J., Phytopathology, 1943, vol. 33, pp. 517–524.

    Google Scholar 

  190. Calabrese, V., Cornelius, C., Dinkova-Kostova, A.T., Calabrese, E.J., and Mattson, M.P., Antioxid. Redox Signal., 2010, vol. 13, no. 11, pp. 1763–1811.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  191. Calabrese, E.J., Microbial Cell, 2014, pp. 145–149.

    Google Scholar 

  192. Nasonov, D.N., Local Reaction of Protoplasm and Gradual Excitation (available at Office of Technical Services, USDepartment of Commerce.), Washington, DC National Science Foundation, 1962.

    Google Scholar 

  193. Simonov, P.V., Tri fazy v reaktsiyakh organizma na vozrastayushchii stimul (Three Phases in the Responses of the Body to Increasing Stimulus), Moscow Izdat. AN SSSR, 1962.

    Google Scholar 

  194. Klomsiri, C., Karplus, P.A., and Poole, L.B., Antioxid. Redox Signal., 2011, vol. 14, no. 6, pp. 1065–1077.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  195. Go, Y.M., Chandler, J.D., and Jones, D.P., Free Radic. Biol. Med., 2015, vol. 84, pp. 227–245. doi 10.1016/j.freeradbiomed.2015.03.022

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  196. Yang, J., Carroll, K.S., and Liebler, D.C., Mol. Cell. Proteomics, 2016, vol. 15, no. 1, pp. 1–11.

    Article  PubMed  CAS  Google Scholar 

  197. Szent-Gyorgyi, A., Bioelectronics: a Study in Cellular Regulations, Defense, and Cancer, New York Academic Press, 1968.

    Google Scholar 

  198. Dil’man, V.M., Bol’shie biologicheskie chasy. (Vvedenie v integral’nuyu meditsinu) (Large Biological Clock. (Introduction to Integral Medicine)), Moscow Znanie, 1986.

    Google Scholar 

  199. Severin, F.F., Feniouk, B.A., and Skulachev, V.P., Biochemistry (Moscow), 2013, vol. 78, no. 9, pp. 1043–1047.

    Article  CAS  Google Scholar 

  200. Routh, V.H., Diabetes Metab. Res. Rev., 2003, vol. 19, no. 5, pp. 348–356.

    Article  CAS  PubMed  Google Scholar 

  201. Toda, C., Kim, J.D., Impellizzeri, D., Cuzzocrea, S., Liu, Z.W., and Diano, S., Cell, 2016, vol. 164, no. 5, pp. 872–883.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  202. Kim, J.D., Toda, C., D’Agostino, G., Zeiss, C.J., DiLeone, R.J., Elsworth, J.D., Kibbey, R.G., Chan, O., Harvey, B.K., Richie, C.T., Savolainen, M., Myohanen, T., Jeong, J.K., and Diano, S., Proc. Natl. Acad. Sci. U. S. A., 2014, vol. 12, no. 32, pp. 11876–11881.

    Article  CAS  Google Scholar 

  203. Parton, L.E., Ye, C.P., Coppari, R., Enriori, P.J., Choi, B., Zhang, C.Y., Xu, C., Vianna, C.R., Balthasar, N., Lee, C.E., Elmquist, J.K., Cowley, M.A., and Lowell, B.B., Nature, 2007, vol. 449, no. 7159, pp. 228–232.

    Article  CAS  PubMed  Google Scholar 

  204. Echtay, K.S., Esteves, T.C., Pakay, J.L., Jekabsons, M.B., Lambert, A.J., Portero-Otín, M., Pamplona, R., Vidal-Puig, A.J., Wang, S., Roebuck, S.J., and Brand, M.D., EMBO J., 2003, vol. 22, no. 16, pp. 4103–4110.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  205. Elmore, M.J., Lamb, A.J., Ritchie, G.Y., Douglas, R.M., Munro, A., Gajewska, A., and Booth, I.R., Mol. Microbiol., 1990, vol. 4, no. 3, pp. 405–412.

    Article  CAS  PubMed  Google Scholar 

  206. Rodriguez, C., Kwon, O., and Georgellis, D., J. Bacteriol., 2004, vol. 186, no. 7, pp. 2085–2090.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  207. Kuhla, B., Boeck, K., Schmidt, A., Ogunlade, V., Arendt, T., Munch, G., and Luth, H.J., Neurobiol. Aging, 2007, vol. 28, no. 1, pp. 29–41.

    Article  CAS  PubMed  Google Scholar 

  208. Brewer, G.J., Exp. Gerontol., 2010, vol. 45, no. 3, pp. 173–179.

    Article  CAS  PubMed  Google Scholar 

  209. Rice, J.C. and Allis, C.D., Curr. Opin. Cell. Biol., 2001, vol. 13, no. 3, pp. 263–273.

    Article  CAS  PubMed  Google Scholar 

  210. Thomas, D.D., Redox Biol., 2015, vol. 5, pp. 225–233. doi 10.1016/j.redox.2015.05.002

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  211. Kosmachevskaya, O.V., Shumaev, K.B., and Topunov, A.F., Biochemistry (Moscow), 2015, vol. 80, no. 13, pp. 1655–1671.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Bach Institute of Biochemistry, Research Center of Biotechnology, Russian Academy of Sciences, Moscow, 119071, Russia

    O. V. Kosmachevskaya, K. B. Shumaev & A. F. Topunov

Authors
  1. O. V. Kosmachevskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. B. Shumaev
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. F. Topunov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. F. Topunov.

Additional information

Original Russian Text © O.V. Kosmachevskaya, K.B. Shumaev, A.F. Topunov, 2017, published in Prikladnaya Biokhimiya i Mikrobiologiya, 2017, Vol. 53, No. 3, pp. 253–270.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kosmachevskaya, O.V., Shumaev, K.B. & Topunov, A.F. Signal and regulatory effects of methylglyoxal in eukaryotic cells (review). Appl Biochem Microbiol 53, 273–289 (2017). https://doi.org/10.1134/S0003683817030103

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0003683817030103

Keywords

Search

Navigation