Abstract
There were no significant deviations from the norm in the functional state of the liver, kidneys, and pancreas in the study of the acute toxicity of iron-molybdenum buckyballs intended for targeted drug delivery. No accumulation of nanoparticles or deviation from the norm in any investigated parameter was detected in the study of subacute toxicity.
Similar content being viewed by others
References
S. D. Caruthers, S. A. Wickline, and G. M. Lanza, “Nanotechnological applications in medicine,” Curr. Opin. Biotechnol. 18(1), 26–30 (2007).
R. C. Dutta, “Drug carriers in pharmaceutical design: promises and progress,” Curr. Pharm. Des. 13(7), 76–79 (2007).
A. Müller, E. Krickemeyer, H. Bügge, M. Schidtmann, and F. Peters, “Organizational forms of matter: an inorganic superfullerene and keplerate based on molybdenum oxide,” Angew. Chem. Int. 37(24), 3360–3363 (1998).
A. Müller, S. Sarkar, S. Q. Nazir Shah, H. Bügge, M. Schmidtmann, Sarkar Shatarupa, P. Kögerler, B. Hauptfleisch, A. X. Trautwein, and V. Schünemann, “Archimedian synthesis and magic numbers: “sizing” giant molybdenum — oxide based molecular spheres of the Keplerate type,” Angew. Chem. Int. Ed. Engl. 38, 3238–3241 (1999).
A. A. Ostroushko, M. O. Tonkushina, and N. A. Martynova, “Mass and charge transfer in systems containing nanocluster molybdenum polyoxometallates with a fullerene structure,” Russ. J. Phys. Chem. A 84(6), 1022 (2010).
A. A. Ostroushko, M. Yu. Sennikov, and M. O. Tonkushina, “Polyoxometallate Mo132 interaction with polyvinyl alcohol,” Zh. Neorg. Khim. 84(4), 666–673 (2009).
F. Tian, D. Cui, H. Schwarz, G. G. Estrada, and H. Kobayashi, “Cytotoxicity of single-wall carbon nanotubes on human fibroblasts,” Toxicol. in Vitro 20, 1202–1212 (2006).
A. Sh. Zaichik and L. P. Churilov, Physiopathology, Vol. 2: Foundations of Pathochemistry (Elbi-SPb, St. Petersburg, 2001) [in Russian].
Yu. V. Chistyakov, Foundations of Bioinorganic Chemistry (Khimiya-KolosS, Moscow, 2007) [in Russian].
A. A. Ostroushko, I. G. Danilova, S. Yu. Medvedeva, I. F. Gette, and M. O. Tonkushina, “Study of safety of molybdenum and iron-molybdenum nanocluster polyoxometalates intended for targeted delivery of drugs,” Ural. Med. Zh. 74(9), 114–117 (2010).
A. A. Ostroushko, I. G. Danilova, I. F. Gette, S. Yu. Medvedeva, M. O. Tonkushina, A. V. Prokofieva, and M. V. Morozova, “Study of safety of molybdenum and iron-molybdenum nanocluster polyoxometalates intended for targeter delivery of drugs,” J. Biomater. Nanobiotechnol., No. 2, 557–560 (2011).
Guide on Experimental (Pre-Clinical) Research of New Pharmacological Matters (Minzdrav RF, Moscow, 2000) [in Russian].
A. A. Ostroushko, I. F. Gette, S. Yu. Medvedeva, M. O. Tonkushina, I. G. Danilova, A. V. Prokof’eva, and M. V. Morozova, “Study of safety of molybdenum and iron-molybdenum nanocluster polyoxometalates intended for targeter delivery of drugs,” Vestn. Ural. Med. Akad. Nauk 34(2), 107–110 (2011).
A. A. Ostroushko, I. F. Gette, I. G. Danilova, S. Yu. Medvedeva, M. O. Tonkushina, and A. V. Prokof’eva, “Chronicle toxicity of molybdenum and ferrum-molybdenum nanocluster polyoxometalates,” Ural. Med. Zh. 89(11), 75–80 (2011).
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © A.A. Ostroushko, I.F. Gette, S.Yu. Medvedeva, I.G. Danilova, E.A. Mukhlynina, M.O. Tonkushina, M.V. Morozova, 2013, published in Rossiiskie Nanotekhnologii, 2013, Vol. 8, Nos. 9–10.
Rights and permissions
About this article
Cite this article
Ostroushko, A.A., Gette, I.F., Medvedeva, S.Y. et al. Study of acute and subacute action of iron-molybdenum nanocluster polyoxometalates. Nanotechnol Russia 8, 672–677 (2013). https://doi.org/10.1134/S1995078013050108
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1995078013050108