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Mechanical characteristics of composites of polylactide and nanosized calcium phosphates formed in supercritical carbon dioxide

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Abstract

Composite materials for biomedical applications based on polylactide, a bioresorbable polymer, and nanosized calcium phosphate (hydroxyapatite) were produced using supercritical (SC) carbon dioxide. For composites with different polymer-to-mineral ratios, the bending stress-strain diagrams were investigated. The elasticity moduli of composites obtained in SC-CO2 from powdered bioresorbable polymer and bioactive nanoceramics ranged elastic modulus of natural bone. Experiments on adhesion of human embryonic fibroblasts demonstrated the suitability of generated samples for use in bone tissue scaffold engineering and regenerative medicine.

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References

  1. E. Nejati, V. Firouzdor, M. B. Eslaminejad, and F. Bagheri, Mater. Sci. Eng. 29, 942 (2009).

    Article  CAS  Google Scholar 

  2. D. Puppi, F. Chiellini, A. M. Piras, and E. Chiellini, Progress Polym. Sci. 35, 403 (2010).

    Article  CAS  Google Scholar 

  3. F. Carrasco, P. Pages, J. Gamez-Perez, O. O. Santana, and M. L. Maspoch, Polymer Degrad. Stabil. 95, 116 (2010).

    Article  CAS  Google Scholar 

  4. Y. Fan, H. Nishida, Y. Shirai, Y. Tokiwa, and T. Endo, Polymer Degrad. Stabil. 86, 197 (2004).

    Article  CAS  Google Scholar 

  5. N. Ignjatovic, S. Tomic, M. Dakic, M. Miljkovic, M. Plavsic, and D. Uskokovic, Biomaterials 20, 809 (1999).

    Article  CAS  Google Scholar 

  6. N. Ignjatovic, M. Plavsic, M. Miljkovic, Lj. Zivkovic, and D. Uskokovic, J. Microscopy, 196, 243 (1999).

    Article  CAS  Google Scholar 

  7. D. J. Mooney, D. F. Baldwin, N. P. Suh, J. P. Vacanti, and R. Langer, Biomaterials 17, 1417 (1996).

    Article  CAS  Google Scholar 

  8. J. J. A. Barry, M. M. C. G. Silva, V. K. Popov, K. M. Shakesheff, and S. M. Howdle, Phil. Trans. A: Math. Phys. Eng. Sci. 364, 249 (2006).

    Article  CAS  Google Scholar 

  9. K. Pielichowska and S. Blazewicz, Adv. Polym. Sci. 232, 97 (2010).

    Article  CAS  Google Scholar 

  10. J. S. Sun, Y. H. Tsuang, W. H. S. Chang, et al., Biomaterials 18, 683 (1997).

    Article  CAS  Google Scholar 

  11. V. N. Bagratashvili, A. I. Volozhin, A. P. Krasnov, V. K. Popov, and S. M. Khould, in Synthesis of New Mineral-Polymer Composites for Implantology and Tissue Engineering, Collected vol., Ed. by V. Ya. Panchenko and V. S. Golubev (Nauka, Interkontakt, 2005), p. 157 [in Russian].

    Google Scholar 

  12. National Institutes of Health Guidelines for Research Using Human Pluripotent Stem Cells. Final Rule, 65 Federal Register 51976-51981 (2000).

  13. Temporary Instruction on Researches in Cell Technology Area and their Use in Health Care (Expert Council of Russian Ministry of Health, 18.04. 2002).

  14. E. N. Chumachenko, A. I. Volozhin, and V. A. Markin, Naukoemk. Tekhnol., No. 2, 49 (2001).

  15. A. N. Chuiko, O. V. Gromov, and V. G. Vybornyi, Stomatolog, No. 1, 44 (2003).

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Authors and Affiliations

  1. Institute of Laser and Information Technologies, Russian Academy of Science, Troitsk, Moscow oblast, Russia

    E. N. Antonov, A. V. Popova & V. V. Trofimov

  2. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia

    I. I. Selezneva

  3. Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Moscow, Russia

    A. Yu. Fedotov & A. S. Fomin

Authors
  1. E. N. Antonov
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  2. A. V. Popova
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  3. I. I. Selezneva
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  4. V. V. Trofimov
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  5. A. Yu. Fedotov
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  6. A. S. Fomin
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Corresponding author

Correspondence to E. N. Antonov.

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Original Russian Text © E.N. Antonov, A.V. Popova, I.I. Selezneva, V.V. Trofimov, A.Yu. Fedotov, A.S. Fomin, 2011, published in Sverkhkriticheskie Flyuidy: Teoriya i Praktika, 2011, Vol. 6, No. 3, pp. 5–14.

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Antonov, E.N., Popova, A.V., Selezneva, I.I. et al. Mechanical characteristics of composites of polylactide and nanosized calcium phosphates formed in supercritical carbon dioxide. Russ. J. Phys. Chem. B 5, 1189–1194 (2011). https://doi.org/10.1134/S1990793111080033

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  • DOI: https://doi.org/10.1134/S1990793111080033

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