Abstract
In some cases standard chemotherapy of acute lymphocytic leukemia (ALL) leads to neurotoxicity; its mechanisms, methods of prognosis, and prevention are being actively studied. The aim of this study was to assess the cerebrospinal fluid (CSF) cytokine profile in children with ALL and neurotoxic side effects of chemotherapy. This prospective study included 24 children with ALL aged from 3 to 17 years. Patients were further subdivided into ALL patients with (the main group) and without neurological complications (the comparison group). The level of CSF cytokines was measured by the Xmap technology (Luminex) using Invitrogen test systems (eBioscience) and the Luminex 200 system. The comparative analysis of the cytokine profile in the group of children with chemotherapy-induced neurotoxic complications revealed elevated levels of chemokine CXCL12 (SDF-1α) and stem cell factor (SCF). The increased level of these cytokines in CSF suggested a relatively risk for development of the toxic peripheral neuropathy.
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ACKNOWLEDGMENTS
The authors are very grateful to the Deputy Chief Physician for Oncology and Hematology of the Regional Children’s Clinical Hospital, Ph.D. L.G. Fechina for invaluable assistance in organizing and conducting the study.
Funding
This study was supported by a grant of the Academic Council of the Ural State Medical University.
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The study was carried out in accordance with the World Medical Association Declaration of Helsinki (Helsinki, 2000). Informed consent was obtained from the legal representatives of the patients to participate in the study. The study design, its novelty, acceptability and acceptability were approved at a meeting of the Local Ethics Committee of the Ural State Medical University on December 16, 2018 (Protocol no. 10).
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Translated by A. Medvedev
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Bazarnyi, V.V., Kovtun, O.P., Koryakina, O.V. et al. The Study of the Cerebrospinal Fluid Cytokine Profile in Children with Acute Lymphocytic Leukemia and Neurotoxic Side Effects of Chemotherapy. Biochem. Moscow Suppl. Ser. B 16, 74–77 (2022). https://doi.org/10.1134/S1990750822010036
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DOI: https://doi.org/10.1134/S1990750822010036