Abstract
Activities of caspases involved in cell death have been investigated in lymphocytes of patients with borderline personality disorders (BPD). In the group of patients with organic mental disorders (OMD) caspase activity decreased in a depressive disorder and increased in an anxiety disorder, thus suggesting activation of apoptosis in lymphocytes of patients with the anxiety disorder. Caspase activities differed in lymphocytes of OMD patients with the depressive disorder and a recurrent depressive disorder. In BPD patients with OMD lymphocyte caspase activity was higher thus indicating activation of apoptosis in these cells. Results can be used for specification of mechanisms of pathogenesis of mental disorders and search for new markers of these diseases.
Similar content being viewed by others
References
Schmidt, H.D., Shelton, R.C., and Duman, R.S., Neuropsychopharmacology, 2011, vol. 36, pp. 2375–2394.
Gladkevich, A., Kauffman, H.F., and Korf, J., Progr. Neuro-Psychopharmacol. Biol. Psychiatr., 2004, vol. 28, pp. 559–576.
Eilat, E., Mendlovic, S., Doron, A., Zakuth, V., and Spirer, Z., J. Immunol., 1999, vol. 163, pp. 533–534.
Szuster-Ciesielska, A., Słotwińska, M., Stachura, A., Marmurowska-Michałowska, H., Dubas-Ślemp, H., Bojarska-Junak, A., and Kandefer-Szerszeń, M., Progr. Neuro-Psychopharmacol. Biol. Psychiatr., 2008, vol. 32, pp. 686–694.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © E.S. Gerasimovich, A.A. Yakovlev, T.A. Druzhkova, M.N. Grishkina, A.B. Guekht, N.V. Gulyaeva, 2016, published in Biomeditsinskaya Khimiya.
Rights and permissions
About this article
Cite this article
Gerasimovich, E.S., Yakovlev, A.A., Druzhkova, T.A. et al. Activation of caspases in lymphocytes of patients with borderline personality disorders. Biochem. Moscow Suppl. Ser. B 10, 246–250 (2016). https://doi.org/10.1134/S1990750816030021
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1990750816030021