Abstract
The aim of this study was to determine the reference interval of serum cobalt-binding capacity (CoBC), and to estimate the effect of factors unrelated to oxidative modification of serum albumin on this diagnostic marker. Healthy volunteers (n = 194), patients with autoimmune diseases (n = 44) and patients with type 2 diabetes mellitus (n = 50) were enrolled in the study. The regional reference interval was found to be 0,462–0,744 mmol Co2+/L of serum. The study of serum CoBC in patients with autoimmune pathology and type 2 diabetes mellitus has shown that the CoBC level strongly depends on the serum protein profile. Therefore, this test may be used to diagnose the ischemia, although other pathologies associated with changes in the ratio of blood protein fractions can also influence the serum CoBC level.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bar-Or, D., Lau, E., Rao, N., Bampos, N., Winkler, J.V., and Curtis, C.G., Ann. Emerg. Med., 1999, vol. 34, p. S56.
Bar-Or, D., Lau, E., and Winkler, J.V., J. Emerg. Med., 2000, vol. 19, pp. 311–315.
Abadie, J.M., Blassingame, C.L., and Bankson, D.D., Ann. Clin. Lab. Sci., 2005, vol. 35, pp. 66–72.
Behera, S., Mangaraj, M., and Mohapatra, P.Ch., Asian Pacific J. Tropic. Dis., 2012, vol. 2, no. 1, pp. 62–65.
Ustün, Y., Engin-Ustün, Y., Oztürk, O., Alanbay, I., and Yaman, H., J. Maternal-Fetal and Neonatal Medicine, 2011, vol. 24, pp. 418–421.
Wu, A., in International Workshop on Ischemia, Barcelona, Spain, 2002, pp. 18–20.
Lopatin, Yu.M., Litus, E.A., Zaitsev, V.G., Ostrovskiy, O.V., Dronova, E.P., Podvorchan, M.A., Trifonova, A.N., and Kosterina, N.S., Sovrem. Probl. Nauki i Obrazonaviya, 2011, no. 6 (www.science-education.ru/100-5114).
Nikitenko, E.A., Zaitsev, V.G., and Ostrovskii, O.V., Biomed. Khim., 2007, vol. 53, pp. 216–220.
Maguire, O.C., O’Sullivan, J., Cunningham, J.R., and Cunningham, S.K., Ann. Clin. Biochem., 2006, vol. 43, pp. 494–499.
Martins, S., Karmali, A., Andrade, J., and Serralheiro, M.L., Mol. Biotechnol., 2006, vol. 33, pp. 103–114.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © E.A. Litus, V.G. Zaitsev, V.E. Verovsky, L.V. Goncharova, G.P. Dudchenko, O.V. Ostrovskij, 2013, published in Biomeditsinskaya Khimiya.
Rights and permissions
About this article
Cite this article
Litus, E.A., Zaitsev, V.G., Verovsky, V.E. et al. Is cobalt-binding capacity of serum a new perspective diagnostic marker?. Biochem. Moscow Suppl. Ser. B 7, 222–225 (2013). https://doi.org/10.1134/S1990750813030086
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1990750813030086