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Murine embryonic stem cells as a model for human embryonic stem-cell research

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Abstract

Over the last several decades, murine embryonic stem cells (mESCs) have been used as a model for human embryonic stem cell (hESC) research. The relevance of this approach has not yet been proven. There is a great deal of evidence that is indicative of substantial differences between these two cell types. An analysis of the literature shows that the differences concern ESC proliferation, self-renewal, and differentiation. Consequently, mESC may be considered as a model object for hESC studies only for some aspects of their biology. The alternative model objects, such as primate ESC, are also discussed briefly in this review.

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Abbreviations

ICM:

inner cell mass

ESC:

embryonic stem cells

mESC:

murine embryonic stem cells

hESC:

human embryonic stem cells

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Original Russian Text © A.S. Grigoryan, P.V. Kruglyakov, 2009, published in Tsitologiya, vol.51, No. 5, 2009, pp. 442–454.

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Grigoryan, A.S., Kruglyakov, P.V. Murine embryonic stem cells as a model for human embryonic stem-cell research. Cell Tiss. Biol. 3, 199–212 (2009). https://doi.org/10.1134/S1990519X09030018

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