Skip to main content
SpringerLink
Log in

Neuroprotective Activity of Docosahexaenoic Acid in the Central and Peripheral Nervous System after Chronic Constriction Injury of the Sciatic Nerve

  • EXPERIMENTAL ARTICLES
  • Published:
Neurochemical Journal Aims and scope Submit manuscript

Abstract—The analgesic and neuroprotective activity of docosahexaenoic acid (DHA, 22:6 n-3) was studied in a model of rat chronic constriction injury of the sciatic nerve. We characterized the morphological and chemical state of the distal sciatic nerve segment and the activity of GFAP-positive astroglia and SP-ergic nerve fibers on the 7th and 28th day after the operation. It was found that DHA improves the morphological state of the sciatic nerve, prevents the degradation of the myelin basic protein and stabilizes the activity level of astroglia and SP-positive nerve fibers in the surface plates of the posterior horns of the spinal cord. In general, DHA has a complex effect on the course of the post-traumatic process in the central and peripheral nervous system, which indicates its high therapeutic potential.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.
Fig. 3.
Fig. 4.

Similar content being viewed by others

REFERENCES

  1. Colloca, L., Ludman, T., Bouhassira, D., Baron, R., Dickenson, A.H., Yarnitsky, D., Freeman, R., Truini, A., Attal, N., Finnerup, N.B., Eccleston, C., Kalso, E., Bennett, D.L., Dworkin, R.H., and Raja, S.N., Nat. Rev. Dis. Prim., 2017, vol. 3, p. 17002.

    Article  Google Scholar 

  2. Woolf, C.J. and Mannion, R.J., Lancet, 1999, vol. 353, pp. 1959–1964.

    Article  CAS  Google Scholar 

  3. Obata, H., Sakurazawa, S., Kimura, M., and Saito, S., Brain Res., 2010, vol. 1363, pp. 72–80.

    Article  CAS  Google Scholar 

  4. Ji, R.-R., Chamessian, A., and Zhang, Y.-Q., Science, 2016, vol. 354, pp. 572–577.

    Article  CAS  Google Scholar 

  5. Pinho-Ribeiro, F.A., Verri, W.A., and Chiu, I.M., Trends Immunol., 2017, vol. 38, pp. 5–19.

    Article  CAS  Google Scholar 

  6. Arcos, M., Palanca, J.M., Montes, F., and Barrios, C., J. Invest. Surg, 2013, vol. 26, no. (3), pp. 109–117.

  7. Farooqui, A.A., Horrocks, L.A., and Farooqui, T., J. Neurochem., 2007, vol. 101, pp. 577–599.

    Article  CAS  Google Scholar 

  8. Bazan, N.G., Curr. Opin. Clin. Nutr. Metab. Care, 2007, vol. 10, pp. 136–141.

    Article  CAS  Google Scholar 

  9. Nakamoto, K. and Nishinaka, T., Biol. Pharm. Bull, 2010, vol. 33, pp. 1070–1072.

    Article  CAS  Google Scholar 

  10. Manzhulo, I.V., Ogurtsova, O.S., Lamash, N.E., Latyshev, N.A., Kasyanov, S.P., and Dyuizen, I.V., Acta Histochem., 2015, vol. 117, pp. 659–666.

    Article  CAS  Google Scholar 

  11. Xu, Z.Z., Liu, X.J., Berta, T., Park, C.K., Lu, N., Serhan, C.N., and Ji, R.R., Ann. Neurol., 2013, vol. 74, no. 3, pp. 490–495.

  12. Bennett, G.J. and Xie, Y.K., Pain, 1988, vol. 33, pp. 87–107.

    Article  CAS  Google Scholar 

  13. Nakazato-Imasato, E. and Kurebayashi, Y., Life Sci., 2009, vol. 84, pp. 622–626.

    Article  CAS  Google Scholar 

  14. Campana, W.M., Myers, R.R., and Rearden, A., Glia, 2003, vol. 41, pp. 213–223.

    Article  Google Scholar 

  15. Liu, H., Mantyh, P.W., and Basbaum, A.I., Nature, 1997, vol. 386, pp. 721–724.

    Article  CAS  Google Scholar 

  16. Wu, L., Xu, H., Ko, S.W., Yoshimura, M., and Zhuo, M., Mol. Pain, 2005, vol. 1, pp. 34–36.

    PubMed  PubMed Central  Google Scholar 

  17. Ren, K., Japan. Dental Sci. Rev., 2010, vol. 46, pp. 86–92.

    Article  Google Scholar 

  18. Hald, A., Nedergaard, S., Hansen, R.R., Ding, M., and Heegaard, A.M., Eur. J. Pain, 2009, vol. 13, pp. 138–145.

    Article  CAS  Google Scholar 

  19. Garrison, C.J., Dougherty, P.M., and Carlton, S.M., Brain Res., 1993, vol. 607, pp. 205–214.

    Article  CAS  Google Scholar 

  20. Coutinho, S.V., Urban, M.O., and Gebhart, G.F., Eur. J. Pharmacol., 2001, vol. 429, pp. 319–325.

    Article  CAS  Google Scholar 

  21. Zimmermann, M., Eur. J. Pharm., 2001, vol. 429, pp. 23–37.

    Article  CAS  Google Scholar 

  22. Yihong, Z., Tamada, Y., Akai, K., and Suwa, F., Okajimas. Folia Anat. Jpn., 2006, vol. 83, pp. 91–96.

    Article  Google Scholar 

  23. Guo, M., Stockert, L., Akbar, M., and Kim, H.Y., J. Mol. Neurosci., 2007, vol. 33, pp. 67–73.

    Article  CAS  Google Scholar 

  24. Nichols, M.L., Allen, B.J., Rogers, S.D., Ghilardi, J.R., Honore, P., Luger, N.M., Finke, M.P., Li, J., Lappi, D.A., Simone, D.A., and Mantyh, P.W., Science, 1999, vol. 286, pp. 1558–1561.

    Article  CAS  Google Scholar 

  25. Cunnane, S.C., Plourde, M., Pifferi, F., Bégin, M., Féart, C., and Barberger-Gateau, P., Prog. Lip. Res., 2009, vol. 48, pp. 239–256.

    Article  CAS  Google Scholar 

  26. Nakamoto, K., Nishinaka, T., Ambo, A., Mankura, M., Kasuya, F., and Tokuyama, S., Eur. J. Pharmacol., 2011, vol. 666, pp. 100–104.

    Article  CAS  Google Scholar 

  27. Mathieu, G., Denis, S., Langelier, B., Denis, I., Lavialle, M., and Vancassel, S., Neurochem. Int., 2010, vol. 56, pp. 94–100.

    Article  Google Scholar 

  28. Wei, T., Guo, T., Li, W., Hou, S., Kingery, W.S., and Clark, J.D., J. Neuroinflam., 2012, vol. 9, p. 181.

    Article  CAS  Google Scholar 

  29. Lukiw, W.J., Cui, J.G., Marcheselli, V.L., Bodker, M., Botkjaer, A., Gotlinger, K., Serhan, C.N., and Bazan, N.G., J. Clin. Invest., 2005, vol. 115, pp. 2774–2783.

    Article  CAS  Google Scholar 

  30. Manzhulo, I., Tyrtyshnaia, A., Kipryushina, Y., Dyuizen, I., Ermolenko, E., and Manzhulo, O., Neurosci. Let., 2018, vol. 672, pp. 6–14.

    Article  CAS  Google Scholar 

Download references

Funding

The study was supported by the Russian Science Foundation (project no. 17-74-20006).

Author information

Authors and Affiliations

  1. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, ul. Palchevskogo 17, 690041, Vladivostok, Russia

    I. V. Manzhulo, A. A. Tyrtyshnaia, O. S. Manzhulo, A. A. Starinets, S. P. Kasyanov & I. V. Dyuizen

  2. Far Eastern Federal University, Vladivostok, Russia

    I. V. Manzhulo, A. A. Tyrtyshnaia, O. S. Manzhulo & A. A. Starinets

Authors
  1. I. V. Manzhulo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. A. Tyrtyshnaia
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. O. S. Manzhulo
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. A. Starinets
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S. P. Kasyanov
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. I. V. Dyuizen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to I. V. Manzhulo.

Ethics declarations

Conflict of interest. The authors declared no conflicts of interest.

Ethical approval. All experimental manipulations with animals are approved by the Commission on Biomedical Ethics of the A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Manzhulo, I.V., Tyrtyshnaia, A.A., Manzhulo, O.S. et al. Neuroprotective Activity of Docosahexaenoic Acid in the Central and Peripheral Nervous System after Chronic Constriction Injury of the Sciatic Nerve. Neurochem. J. 14, 101–107 (2020). https://doi.org/10.1134/S1819712420010158

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1819712420010158

Keywords:

Search

Navigation