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Modeling the induced mutation process in bacterial cells with defects in excision repair system

  • Radiobiology, Ecology and Nuclear Medicine
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Abstract

A mathematical model of the UV-induced mutation process in Escherichia coli cells with defects in the uvrA and polA genes has been developed. The model describes in detail the reaction kinetics for the excision repair system. The number of mismatches as a result of translesion synthesis is calculated for both wild-type and mutant cells. The effect of temporal modulation of the number of single-stranded DNA during postreplication repair has been predicted. A comparison of effectiveness of different repair systems has been conducted.

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Authors and Affiliations

  1. Joint Institute for Nuclear Research, Dubna, Moscow oblast, 141980, Russia

    A. N. Bugay, M. A. Vasilyeva, E. A. Krasavin & A. Yu. Parkhomenko

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  1. A. N. Bugay
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  2. M. A. Vasilyeva
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  3. E. A. Krasavin
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  4. A. Yu. Parkhomenko
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Correspondence to A. N. Bugay.

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Original Russian Text © A.N. Bugay, M.A. Vasilyeva, E.A. Krasavin, A.Yu. Parkhomenko, 2015, published in Pis’ma v Zhurnal Fizika Elementarnykh Chastits i Atomnogo Yadra, 2015.

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Bugay, A.N., Vasilyeva, M.A., Krasavin, E.A. et al. Modeling the induced mutation process in bacterial cells with defects in excision repair system. Phys. Part. Nuclei Lett. 12, 850–862 (2015). https://doi.org/10.1134/S1547477115070067

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