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A Facile One-Pot Four-Component Green Synthesis of 4-(1H-Indol-2-yl)-4H-chromenes Conjugated with Phthalazine-1,4-diones

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Abstract

The synthesis of 2-(2-amino-4-(1H-indol-2-yl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chro­mene-3-carbonyl)-2,3-dihydrophthalazine-1,4-diones with good yields of 80–85% was accomplished by reacting diethyl phthalate, 2-cyanoacetohydrazide, 1H-indole-2-carbaldehydes, and 5,5-dimethylcyclohexane-1,3-dione in [BMIM]BF4 as ionic liquid medium at 70–75°C for 110–120 min. The product structure was characterized by NMR and mass spectrometry. The proposed synthetic strategy has the remarkable advantages of excellent yields, straightforward protocol, environmental friendliness, short reaction times, and mild reaction conditions. There is no need for catalyst or solvent since a catalytically active ionic liquid is used as a medium.

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ACKNOWLEDGMENTS

The authors are thankful to the authorities of Maharaja Agrasen University, Baddi, for providing the necessary research facilities.

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  1. School of Basic and Applied Sciences, Maharaja Agrasen University, 174103, Baddi, India

    S. Dhavaria & M. Dhiman

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  1. S. Dhavaria
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  2. M. Dhiman
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Correspondence to M. Dhiman.

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Dhavaria, S., Dhiman, M. A Facile One-Pot Four-Component Green Synthesis of 4-(1H-Indol-2-yl)-4H-chromenes Conjugated with Phthalazine-1,4-diones. Russ J Org Chem 59, 726–732 (2023). https://doi.org/10.1134/S1070428023040231

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