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Synthesis and Antibacterial Activity of New Oxadiazolylbenzodioxane Derivatives

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Abstract

Reactions of 5-(1,4-benzodioxan-2-yl)-1,3,4-oxadiazole-2-thiol with N-substituted chloroacetamides gave a series of the corresponding derivatives at the sulfur atom. Addition reactions of 5-(1,4-benzodioxan-2-yl)-1,3,4-oxadiazole-2-thiol to the C=C double bond of acrylonitrile, acrylamide, and ethyl acrylate, as well as Mannich condensation with morpholine and piperidine, were studied. The synthesized compounds were evaluated for their antibacterial activity.

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Authors and Affiliations

  1. Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, 0014, Yerevan, Armenia

    A. S. Avagyan, S. O. Vardanyan, A. B. Sargsyan, A. A. Aghekyan, H. A. Panosyan, R. V. Paronikyan, H. M. Stepanyan & R. E. Muradyan

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  1. A. S. Avagyan
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  2. S. O. Vardanyan
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  3. A. B. Sargsyan
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  4. A. A. Aghekyan
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  5. H. A. Panosyan
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  6. R. V. Paronikyan
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  7. H. M. Stepanyan
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  8. R. E. Muradyan
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Correspondence to A. A. Aghekyan.

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Avagyan, A.S., Vardanyan, S.O., Sargsyan, A.B. et al. Synthesis and Antibacterial Activity of New Oxadiazolylbenzodioxane Derivatives. Russ J Org Chem 56, 385–389 (2020). https://doi.org/10.1134/S1070428020030033

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  • DOI: https://doi.org/10.1134/S1070428020030033

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