Abstract
3,11-Dihydroxy and 3,11-dioxo triterpenoids of the fusidane series reacted with acrylonitrile in 1,4-dioxane in the presence of alkali and phase-transfer catalyst to give mono- and bis(2-cyanoethoxy) and 2-cyanoethyl derivatives. The reaction with 3,11-dioxo analog afforded 2,2-disubstituted derivative as a result of addition of two cyanoethyl groups to the α-position with respect to the C3=O carbonyl group. The isolated compounds were screened for antibacterial and antifungal activities.
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Original Russian Text © E.V. Salimova, A.G. Mamaev, E.V. Tret’yakova, O.S. Kukovinets, A.R. Mavzyutov, K.Yu. Shvets, L.V. Parfenova, 2018, published in Zhurnal Organicheskoi Khimii, 2018, Vol. 54, No. 9, pp. 1395–1402.
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Salimova, E.V., Mamaev, A.G., Tret’yakova, E.V. et al. Synthesis and Biological Activity of Cyanoethyl Derivatives of Fusidic Acid. Russ J Org Chem 54, 1411–1418 (2018). https://doi.org/10.1134/S1070428018090245
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DOI: https://doi.org/10.1134/S1070428018090245