Skip to main content
Log in

Formation of pyrimidin-2-ylcyanamide and 2-aminopyrimidine in the reaction of aniline derivatives with cyanamide and dimethylamino-1-pyridyl-2-propenone

  • Published:
Russian Journal of Organic Chemistry Aims and scope Submit manuscript

Abstract

Substituted o- and p-nitroanilines and m-benzylaminoanilines in the reaction with cyanamide failed to yield the corresponding arylguanidines, and in the presence of 3-dimethylamino-1-(3-pyridyl)-2-propen-1-one formed 4-pyridyl-substituted pyrimidin-2-ylcyanamides and 2-amino-pyrimidines.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Koroleva, E.V., Gusak, K.N., and Ignatovich, Zh.V., Usp. Khim., 2010, vol. 79, p. 720.

    Google Scholar 

  2. Paul, R., Halet, W.A., Hanifin, J.W., Reich, M.F., Johnson, B.D., Lenhard, R.H., Dusza, J.P., Kerwar, S.S., Yangi-Lin, Pickett, W.C., Seifert, C.M., Torley, L.M., Tarrant, M.E., and Wrenn, S.J., J. Med. Chem., 1993, vol. 36, p. 2716.

    Article  CAS  Google Scholar 

  3. Szakacs, Z., Beni, S., Vagra, Z., Orfi, L., Keri, G., and Noszal, B., J. Med. Chem., 2005, vol. 48, p. 249.

    Article  CAS  Google Scholar 

  4. Zimmermann, J., WO Patent 0564409, 1994.

  5. Kankan, R.N. and Rao, D.R., WO Patent 074502, 2004

  6. Szczepek, W., Luniewsky, W., Kaczmarek, L., Zagrodzki, B., Samson-Lazinska, D., Szelejewski, W., Skarzynski, M., WO Patent 071130, 2006.

  7. Koroleva, E.V., Ignatovich, Zh.V., Gusak, K.N., and Kovalev, V.V., Izv. Belarussian Akad. Nauk, Ser. Khim. Nauk, 2010, no. 2, p. 84.

Download references

Author information

Authors and Affiliations

Authors

Additional information

Original Russian Text © E.V. Koroleva, Zh.V. Ignatovich, S.V. Ignatovich, K.N. Gusak, 2011, published in Zhurnal Organicheskoi Khimii, 2011, Vol. 47, No. 8, pp. 1204–1208.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Koroleva, E.V., Ignatovich, Z.V., Ignatovich, S.V. et al. Formation of pyrimidin-2-ylcyanamide and 2-aminopyrimidine in the reaction of aniline derivatives with cyanamide and dimethylamino-1-pyridyl-2-propenone. Russ J Org Chem 47, 1222–1226 (2011). https://doi.org/10.1134/S1070428011080173

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1070428011080173

Keywords

Navigation