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Peptide Modulators of ASIC Channels of the Sea Anemone Urticina aff. coriacea (Cuvier, 1798) from the Sea of Okhotsk

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Abstract

A search for biologically active peptides has been performed in an aqueous extract of the sea anemone Urticina aff. coriacea (Cuvier, 1798) (Actiniidae) from the Sea of Okhotsk. A separation of the peptides by size-exclusion chromatography and subsequent electrophysiological testing have shown that peptides of three fractions can completely inhibit currents of mammalian ASIC1a channels. The sea anemone Urticina aff. coriacea is believed to be a promising source of novel peptides that interact with ASIC channels.

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Authors and Affiliations

  1. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences, 690022, Vladivostok, Russia

    I. N. Gladkikh, A. N. Kvetkina, R. S. Kalina, B. B. Grebnev, M. M. Monastyrnaya & E. P. Kozlovskaya

  2. Zhirmunsky Institute of Marine Biology, National Scientific Center of Marine Biology, Far East Branch, Russian Academy of Sciences, 690041, Vladivostok, Russia

    E. E. Kostina

  3. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997, Moscow, Russia

    S. G. Koshelev & S. A. Kozlov

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  1. I. N. Gladkikh
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  2. A. N. Kvetkina
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  6. S. G. Koshelev
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  8. M. M. Monastyrnaya
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Correspondence to I. N. Gladkikh.

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Translated by E. Shvetsov

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Gladkikh, I.N., Kvetkina, A.N., Kostina, E.E. et al. Peptide Modulators of ASIC Channels of the Sea Anemone Urticina aff. coriacea (Cuvier, 1798) from the Sea of Okhotsk. Russ J Mar Biol 44, 458–464 (2018). https://doi.org/10.1134/S1063074018060044

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