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Prospects for Inhalation Delivery of Medical Protectors against Radiation Damage

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Abstract—The possibilities of improving medical protectors administered by inhalation for urgent assistance in emergency situations are discussed in this paper. The advantages of this method of administration are characterized, and the expediency of using portable dry powder inhalers as a technical means of drug delivery is substantiated. The sources containing information on the inhalation use of drugs from various pharmacological groups has been examined. Radioprotective agents (cystamine, indraline, naphthyzine), radioprotective agents for prophylactic use (estradiol), means of preventing and arresting the primary reaction to radiation (ondansetron, metoclopramide, metacin), radiomitigators (analogs of granulocyte colony stimulating factor (G-CSF), growth hormone, betaleukin), and incorporated binding agents radionuclides (pentacin) should be considered as the most promising medical preparations for inhalation under exposure to radiation factors. This is determined by the presence of effective inhalation forms approved for medical use and registered in the Russian Federation, as well as their technological feasibility.

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  1. State Research Testing Institute of Military Medicine, Ministry of Defense, St. Petersburg, Russia

    I. M. Ivanov, A. S. Nikiforov, M. A. Yudin, S. V. Chepur, Yu. A. Proshina & A. M. Sventitskaya

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  1. I. M. Ivanov
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  2. A. S. Nikiforov
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  3. M. A. Yudin
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Correspondence to Yu. A. Proshina.

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Ivanov, I.M., Nikiforov, A.S., Yudin, M.A. et al. Prospects for Inhalation Delivery of Medical Protectors against Radiation Damage . Biol Bull Russ Acad Sci 47, 1669–1679 (2020). https://doi.org/10.1134/S106235902012002X

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