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Chromatographic analysis of Passifit multicomponent pharmaceutical syrup

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Abstract

Procedures are developed for the qualitative analysis of a new pharmaceutical preparation, Passifit syrup. The conditions for the separation of the active substances were optimized. Valerian and hop extracts were detected by thin-layer chromatography on Kieselgel 60/Kieselguhr F254 plates. Menthol (the volatile component of peppermint oil), thymol and its isomer carvacrol (the components of thyme extract), and sorbic acid (preserving agent) were identified by gas-liquid chromatography on a capillary column with an OV-101 stationary phase and a flame-ionization detector. Luteolin, thymol, rutin, and sorbic acid were identified by reversed-phase HPLC on a Zorbax SB C18 column in a gradient elution mode with UV detection at 210 and 330 nm. Rutin was not detected among the components of the syrup.

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References

  1. Komarova, E.L., Tsybul’ko, N.S., Sheichenko, V.I., Khorlin, A.Ya., Fonin, V.S., Ivleva, Zh.Yu., and Popov, D.M., Khim.-Farmats. Zhurnal, 2000, vol. 34, p. 22.

    Google Scholar 

  2. High Resolution Gas Chromatography, Hyver, K.J., Ed., Hewlett-Packard, 1989.

  3. Khimicheskii analiz lekarstvennykh rastenii (Chemical Analysis of Medicianl Plants), Grinkevich, N.I. and Safronich, L.N., Eds., Moscow: Vysshaya Shkola, 1983.

    Google Scholar 

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Authors and Affiliations

  1. OAO Pharmstandard-Leksredstva, Vtoraya Agregatnaya ul. 1a/18, Kursk, 305039, Russia

    G. B. Golubitskii & V. V. Dyul’dina

  2. Dubna International University of Nature, Society, and Human Being, Universitetskaya ul. 19, Dubna, Moscow oblast, 141980, Russia

    E. M. Basova

  3. Department of Chemistry, Moscow State University, Leninskie gory, Moscow, 119992, Russia

    V. M. Ivanov

  4. Kursk State Medical University, ul. K. Marksa 3, Kursk, 305004, Russia

    E. V. Budko

Authors
  1. G. B. Golubitskii
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  2. V. V. Dyul’dina
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  3. E. M. Basova
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  4. V. M. Ivanov
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  5. E. V. Budko
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Additional information

Original Russian Text © G.B. Golubitskii, V.V. Dyul’dina, E.M. Basova, V.M. Ivanov, E.V. Budko, 2008, published in Zhurnal Analiticheskoi Khimii, 2008, Vol. 63, No. 5, pp. 524–531.

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Golubitskii, G.B., Dyul’dina, V.V., Basova, E.M. et al. Chromatographic analysis of Passifit multicomponent pharmaceutical syrup. J Anal Chem 63, 477–484 (2008). https://doi.org/10.1134/S1061934808050134

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  • DOI: https://doi.org/10.1134/S1061934808050134

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