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The Effect of Molecular Architecture of Sulfobutyl Ether β-Cyclodextrin Nanoparticles on Physicochemical Properties of Complexes with Moxifloxacin

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Abstract

A method has been developed for nanoparticles synthesis based on oligomers of sulfobutyl ether β-cyclodextrin (SBE-β-CD) and their structure has been studied by FTIR spectroscopy. The physicochemical properties of “guest−host” inclusion complexes formed by SBE-β-CD and its oligomers with moxifloxacin have been investigated. It has been shown that, as compared with SBE-β-CD, the synthesized oligomers have an increased affinity for moxifloxacin: the dissociation constants for the complexes of monomeric and oligomeric SBE-β-CD are (1.0 ± 0.3) × 10−4 and nearly 5 × 10−6 M, respectively. The binding efficiency increases due to the multy-point interaction of a moxifloxacin molecule with functional groups of the oligomeric carrier. SBE-β-CD oligomers are promising carriers for drugs, in particular, fluoroquinolone-based antibacterial agents, and may be used for the development of new compositions with improved solubility, bioavailability, and prolonged drug release.

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References

  1. Le-Deigen, I.M., Skuredina, A.A., and Kudryashova, E.V., Russian Journal of Bioorganic Chemistry, 2017, vol. 43(5), p. 487.

    Article  Google Scholar 

  2. Loftsson, T. and Duchene, D., Int. J. Pharm. 2007, vol. 329, p. 1.

    Article  CAS  Google Scholar 

  3. Deigen, I.M., Egorov, A.M., and Kudryashova, E.V., Moscow University Chemistry Bulletin, 2016, 71(1), p. 1.

    Article  Google Scholar 

  4. Skuredina, A.A., Le-Deygen, I.M., Uporov, I.V., and Kudryashova, E.V., Colloid J. 2017, vol. 79, p. 668.

    Article  CAS  Google Scholar 

  5. Chadha, R., Kashid, N., and Saini, A., J. Sci. Ind. Res., 2014, vol. 63, p. 211.

    Google Scholar 

  6. Del Valle, E.M., Process Biochem. 2004, vol. 34, p. 1033.

    Article  CAS  Google Scholar 

  7. http://images.alfresco.advanstar.com/alfresco_images/pharma/2014/08/22/cc14038c-5022-4d20-b3d2-0bc14c095065/article-36186.pdf.

  8. Rodriguez-Aller, M., Guinchard, S., Guillarme, D., Pupier, M., Jeannerat, D., Rivara-Minten, E., Veuthey, J., and Gurny, R., Eur. J. Pharm. Biopharm. 2015, vol. 95, p. 203.

    Article  CAS  PubMed  Google Scholar 

  9. Mura, P., J. Pharm. Biomed. Anal., 2014, vol. 101, p. 238.

    Article  CAS  PubMed  Google Scholar 

  10. Szente, L. and Szejtli, J., Adv. Drug Deliv. Rev. 1999, vol. 36, p. 17.

    Article  CAS  Google Scholar 

  11. Shah, M., Shah, V., Ghosh, A., Zhang, Z., and Minko, T., J. Pharm. Pharmacol., 2014, vol. 2, no. 2, p. 8.

    Google Scholar 

  12. Le-Deygen, I.M., Skuredina, A.A., Uporov, I.V., and Kudryashova, E.V., Anal. Bioanal. Chem. 2017, vol. 409, p. 6451.

    Article  CAS  PubMed  Google Scholar 

  13. Xu, J., Zhang, Y., Li, X., and Zheng, Y., J. Mol. Struct., 2017, vol. 1141, p. 328.

    Article  CAS  Google Scholar 

  14. Deng, Y., Pang, Y., Guo, Y., Ren, Y., Wang, F., and Liao, X., J. Mol. Struct., 2016, vol. 1118, p. 307.

    Article  CAS  Google Scholar 

  15. Ma, M. and Li, D., Chem. Mater. 1999, vol. 11, p. 872.

    Article  CAS  Google Scholar 

  16. Gidwani, B. and Vyas, A., Colloids Surf. B 2014, vol. 114, p. 130.

    Article  CAS  Google Scholar 

  17. Ogoshi, T. and Harada, A., Sensors 2008, vol. 8, p. 4961.

    Article  CAS  PubMed  Google Scholar 

  18. Plata, M., Contento, A., and Rios, A., Sensors 2010, vol. 10, p. 2511.

    Article  CAS  PubMed  Google Scholar 

  19. Zhu, X. and Ping, W., Spectrochim. Acta 2014, vol. 132, p. 38.

    Article  CAS  Google Scholar 

  20. Lyashenko, D.Yu., Poverkhnost, 2014, no. 6(21), p. 56.

    Google Scholar 

  21. Junthip, J., Tabary, N., Leclercq, L., and Martel, B., Carbohydr. Res. 2015, vol. 126, p. 156.

    Article  CAS  Google Scholar 

  22. Cryan, S., Holohan, A., Donohue, R., Darcy, R., and O’Driscoll, C., Eur. J. Pharm. Sci. 2004, vol. 21, p. 625.

    Article  CAS  PubMed  Google Scholar 

  23. Wester, P., Van der Heijden, V., Bisschop, A., and Van Esch, G.J., Toxicology, 1985, vol. 36, p. 325.

    Article  CAS  PubMed  Google Scholar 

  24. Kono, H., Nakamura, T., Hashimoto, H., and Shimizu, Y., Carbohydr. Res. 2015, vol. 128, p. 11.

    Article  CAS  Google Scholar 

  25. Sukhoverkov, K.V., Deigen, I.M., Egorov, A.M., and Kudryashova, E.V., Sverkhkrit. Flyuidy: Teor. Prakt. 2017, vol. 12(4), p. 66.

    Google Scholar 

  26. Kudryashova, E.V., Deigen, I.M., Sukhoverkov, K.V., Filatova, L.Yu., Klyachko, N.L., Vorobei, A.M., Pokrovskii, O.I., Ustinovich, K.B., Parenago, O.O., Antonov, E.N., Dunaev, A.G., Krotova, L.I., Popov, V.K., and Egorov, A.M., Russian Journal of Physical Chemistry, 2016, vol. 10(8), p. 1.

    Google Scholar 

  27. Kudryashova, E.V., Sukhoverkov, K.V., Deigen, I.M., Vorobei, A.M., Pokrovskii, O.I., Parenago, O.O., Presnov, D.E., and Egorov, A.M., Journal of Physical Chemistry B, 2017, vol. 11(7), p. 1153.

    CAS  Google Scholar 

  28. Sukhoverkov, K.V., Kudryashova, E.V., Egorov, A.M., Glazunova, K.V., Acta Naturae, 2016, Spec. Issue C, p. 155.

    Google Scholar 

  29. Kurkov, S.V. and Loftsson, T., Int. J. Pharm. 2013, vol. 453, p. 167.

    Article  CAS  PubMed  Google Scholar 

  30. Belyakova, L.A., Lyashenko, D.Yu., Varvarin, A.M., Ryabov, S.V, Kercha, Yu.Yu., and Namor, D., Ukr. Khim. Zh. 2005, vol. 71, no. 8, p. 86.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Chemistry, Moscow State University, Moscow, 119296, Russia

    A. A. Skuredina, I. M. Le-Deygen & E. V. Kudryashova

Authors
  1. A. A. Skuredina
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  2. I. M. Le-Deygen
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  3. E. V. Kudryashova
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Correspondence to A. A. Skuredina.

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Original Russian Text © A.A. Skuredina, I.M. Le-Deygen, E.V. Kudryashova, 2018, published in Kolloidnyi Zhurnal, 2018, Vol. 80, No. 3, pp. 330–337.

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Skuredina, A.A., Le-Deygen, I.M. & Kudryashova, E.V. The Effect of Molecular Architecture of Sulfobutyl Ether β-Cyclodextrin Nanoparticles on Physicochemical Properties of Complexes with Moxifloxacin. Colloid J 80, 312–319 (2018). https://doi.org/10.1134/S1061933X18030134

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