Skip to main content
SpringerLink
Log in

Structure and properties of complexes of polycationic brushes with anionic liposomes

  • Polyelectrolytes
  • Published:
Polymer Science Series A Aims and scope Submit manuscript

Abstract

The adsorption of anionic lipid vesicles (liposomes) on the surfaces of colloidal particles containing grafted polycationic chains (cationic brushes) is studied. The stability of liposome-brush complexes in aqueous salt solutions increases with the content of anionic lipid in the liposomal membrane; complexes with liposomes containing 20 and 30 mol% anionic lipids do not dissociate into individual components in a 1.2 M NaCl solution. The integrity of the brush-bound liposomes is preserved. The developed approach can be used to obtain nanosized carriers for biologically active compounds.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. A. D. Bangham, M. W. Hill, and N. G. A. Miller, in Methods in Membrane Biology, Ed. by E. D. Korn (Plenum, New York, 1974).

    Google Scholar 

  2. T. Nii and F. Ishii, Int. J. Pharm. 298, 198 (2005).

    Article  CAS  Google Scholar 

  3. A. K. Thompson, A. Couchoud, and H. Singh, Dairy Sci. Technol. 89, 99 (2009).

    Article  CAS  Google Scholar 

  4. L. Zhang, F. X. Gu, J. M. Chan, et al., Clin. Pharmacol. Therapeutics 83, 761 (2008).

    Article  CAS  Google Scholar 

  5. D. D. Lasic, Liposomes. From Physics to Applications (Elsevier, Amsterdam, 1993).

    Google Scholar 

  6. S. G. Patil, S. G. Gattani, R. S. Gaud, et al., Pharma Rev. 18(3), 53 (2005).

    Google Scholar 

  7. R. P. Richter, R. Bérat, and A. R. Brisson, Langmuir 22, 3497 (2006).

    Article  CAS  Google Scholar 

  8. C. Yoshina-Ishii, G. P. Miller, M. L. Kraft, et al., J. Am. Chem. Soc. 127, 1356 (2005).

    Article  CAS  Google Scholar 

  9. A. A. Yaroslavov, A. V. Sybachin, M. Schrinner, et al., J. Am. Chem. Soc. 132, 5948 (2010).

    Article  CAS  Google Scholar 

  10. Y. Mei, A. Wittemann, G. Sharma, et al., Macromolecules 36, 3452 (2003).

    Article  CAS  Google Scholar 

  11. L. Samokhina, M. Schrinner, and M. Ballauff, Langmuir 23, 3615 (2007).

    Article  CAS  Google Scholar 

  12. A. E. Gad, Biochim. Biophys. Acta-Biomembr. 728, 377 (1983).

    Article  CAS  Google Scholar 

  13. A. A. Yaroslavov, E. A. Kiseliova, O. Yu. Udalykh, and V. A. Kabanov, Langmuir 14, 5160 (1998).

    Article  CAS  Google Scholar 

  14. R. B. Gennis, Biomembranes: Molecular Structure and Function (Springer, New York, 1989; Mir, Moscow, 1997).

    Google Scholar 

  15. H. Kahler and B. J. Lloyd, Jr., Science (Washington, D. C.) 114, 2950 (1951).

    Article  Google Scholar 

  16. A. V. Sybachin, A. A. Efimova, E. A. Litmanovich, F. M. Menger, and A. A. Yaroslavov, Langmuir 23, 10034 (2007).

    Article  CAS  Google Scholar 

  17. A. A. Yaroslavov, N. S. Melik-Nubarov, and F. M. Menger, Acc. Chem. Res. 39, 702 (2006).

    Article  CAS  Google Scholar 

  18. Juan A. San, D. Letourneur, and V. A. Izumrudov, Bioconjug. Chem. 18, 922 (2007).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Faculty of Chemistry, Moscow State University, Moscow, 119991, Russia

    O. V. Zaborova, A. V. Sybachin & A. A. Yaroslavov

  2. Department of Physics, Humboldt University, Newtonstr. 15, 12489, Berlin, Germany

    M. Ballauff

  3. Helmholtz-Zentrum Berlin für Materialien und Energie, Hahn-Meitner-Platz 1, 14109, Berlin, Germany

    M. Ballauff

Authors
  1. O. V. Zaborova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. V. Sybachin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Ballauff
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. A. Yaroslavov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. V. Sybachin.

Additional information

Original Russian Text © O.V. Zaborova, A.V. Sybachin, M. Ballauff, A.A. Yaroslavov, 2011, published in Vysokomolekulyarnye Soedineniya, Ser. A, 2011, Vol. 53, No. 11, pp. 1877–1884.

This work was supported by the Russian Foundation for Basic Research, project no.11-03-00936.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zaborova, O.V., Sybachin, A.V., Ballauff, M. et al. Structure and properties of complexes of polycationic brushes with anionic liposomes. Polym. Sci. Ser. A 53, 1019–1025 (2011). https://doi.org/10.1134/S0965545X11110137

Download citation

  • Received:

  • Revised:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0965545X11110137

Keywords

Search

Navigation