Abstract
Carboxylation of o-cresol, m-cresol, and p-cresol with sodium ethyl carbonate (SEC) proceeds regioselectively with the formation of cresotic acids: 2-hydroxy-3-methylbenzoic acid, 2-hydroxy-4-methylbenzoic acid, and 2-hydroxy-5-methylbenzoic acid, respectively. Optimal conditions for conducting the process have been found to be as follows: the reactants ratio of [cresol]: [sodium ethyl carbonate] = (1.5–2): 1, T = 180–185°C, \({P_{C{O_2}}}\) = 10 atm, and t = 6–7 h. Simple and convenient methods for the synthesis of cresotic acids, which can be used for their industrial manufacturing, have been developed.
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Original Russian Text © Kh.A. Suerbaev, E.G. Chepaikin, N.Zh. Kudaibergenov, G.Zh. Zhaksylykova, 2016, published in Neftekhimiya, 2016, Vol. 56, No. 4, pp. 414–418.
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Suerbaev, K.A., Chepaikin, E.G., Kudaibergenov, N.Z. et al. Synthesis of cresotic acids by carboxylation of cresols with sodium ethyl carbonate. Pet. Chem. 56, 646–650 (2016). https://doi.org/10.1134/S0965544116070161
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DOI: https://doi.org/10.1134/S0965544116070161