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Solubility of esomeprazole magnesium trihydrate in alcohols at temperatures from 298.15 to 318.15 K

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Abstract

The solubility of esomeprazole magnesium trihydrate in methanol, ethanol, 1-propanol and 1-butanol was determined at temperatures ranging from 298.15 to 318.15 K at atmospheric pressure using gravimetrical method. The highest solubility is found in 1-butanol and lowest in ethanol. The experimental solubility data are correlated by the modified Apelblat equation. Thermodynamic properties such as dissolution enthalpy, Gibb’s energy, and entropy of mixing have been determined from the solubility data.

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Authors and Affiliations

  1. Physical Chemical Laboratory, Department of Chemistry, Saurashtra University, Rajkot, 360005, India

    K. Bhesaniya & S. Baluja

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  1. K. Bhesaniya
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  2. S. Baluja
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Correspondence to S. Baluja.

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Bhesaniya, K., Baluja, S. Solubility of esomeprazole magnesium trihydrate in alcohols at temperatures from 298.15 to 318.15 K. Russ. J. Phys. Chem. 87, 2187–2190 (2013). https://doi.org/10.1134/S0036024413130062

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  • DOI: https://doi.org/10.1134/S0036024413130062

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