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A Complex Study of the Peculiarities of Blood Serum Absorption of Rats with Experimental Liver Cancer

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Abstract

Terahertz time-domain spectroscopy (THz-TDS) in the 0.05–1.0 THz frequency range was used to study the blood serum of rats in the dynamics of experimental liver cancer. It was shown that the THz transmission spectra of samples from healthy animals and 14 and 28 days after tumor cells implantation are similar in shape, but differ in amplitude. There is a change in the biochemical composition of the blood, including a decrease in the protein content, by the 28th day of the experiment. The observed changes in the THz response are explained by a decrease in the number of protein molecules and bound water and correlate with changes in the refractive index in the visible and near-IR ranges from 480 to 1550 nm, measured using a multiwave refractometer.

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Funding

This study was supported by the Russian Foundation for Basic Research (project no. 17-00-00275 (17-00-00270, 17-00-00272) in the medical–biological part and project no. 18-52-00040 in part of the development of THz technology.

Author information

Authors and Affiliations

  1. National Research Centre Kurchatov Institute, 123182, Moscow, Russia

    M. M. Nazarov

  2. Institute of Laser Physics, Siberian Branch, Russian Academy of Sciences, 630090, Novosibirsk, Russia

    O. P. Cherkasova

  3. Tomsk State University, 634050, Tomsk, Russia

    O. P. Cherkasova, E. N. Lazareva & V. V. Tuchin

  4. Novosibirsk State Technical University, 630073, Novosibirsk, Russia

    O. P. Cherkasova

  5. Saratov State University, 410012, Saratov, Russia

    E. N. Lazareva & V. V. Tuchin

  6. Saratov State Medical University, 410012, Saratov, Russia

    A. B. Bucharskaya & N. A. Navolokin

  7. Institute of Precision Mechanics and Control, Russian Academy of Sciences, 410028, Saratov, Russia

    V. V. Tuchin

  8. Moscow State University, 119991, Moscow, Russia

    A. P. Shkurinov

  9. Institute for Problems of Laser and Information Technologies of the Russian Academy of Sciences, Branch of Federal Scientific Research Center Crystallography and Photonics, 140700, Shatura, Russia

    A. P. Shkurinov

Authors
  1. M. M. Nazarov
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  3. E. N. Lazareva
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  4. A. B. Bucharskaya
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  6. V. V. Tuchin
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  7. A. P. Shkurinov
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Corresponding author

Correspondence to O. P. Cherkasova.

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All applicable international, national, and/or institutional guidelines for the care and use of animals have been implemented.

CONFLICT OF INTEREST

The authors declare no conflict of interest.

Additional information

Translated by I. Shipounova

The 22nd Annual Conference Saratov Fall Meeting 2018 (SFM’18): VI International Symposium “Optics and Biophotonics” and XXII International School for Junior Scientists and Students on Optics, Laser Physics, and Biophotonics, September 24–29, 2018, Saratov, Russia. https://www.sgu.ru/structure/fiz/saratov-fall-meeting/previousconferences/saratov-fall-meeting-2018

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Nazarov, M.M., Cherkasova, O.P., Lazareva, E.N. et al. A Complex Study of the Peculiarities of Blood Serum Absorption of Rats with Experimental Liver Cancer. Opt. Spectrosc. 126, 721–729 (2019). https://doi.org/10.1134/S0030400X19060183

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  • DOI: https://doi.org/10.1134/S0030400X19060183

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