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Radiation-Induced Transformations of 2-Fluoroethanol in Aqueous Solutions

  • RADIATION CHEMISTRY
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Abstract

Steady-state radiolysis has been used to study the radiation-induced transformations of 2-fluoroethanol in dilute aqueous solutions as a model system for examining the autoradiolytic dehalogenation of the radiopharmaceutical drug 2-[18F]fluorodeoxyglucose ([18F]FDG). A derivatization–gas chromatography procedure for determining the fluoride anion in the presence of organofluorine compounds has been developed. It has been established that •OH and H• induced the dehalogenation of 2-fluoroethanol in aqueous solutions. Unlike bromo- and chlorohydrins, 2-fluoroethanol does not interact with \({\text{e}}_{{{\text{aq}}}}^{ - }\) according to the dissociative attachment mechanism. It has been shown that О2 halved the radiation-chemical yield of fluoride due to the oxidation of hydroxyl-containing carbon-centered radicals of 2-fluoroethanol. The constant of unimolecular dehalogenation of the 2-fluoroethanol radical is 3.9 × 106 s−1, as calculated using the method of competing reactions.

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REFERENCES

  1. Trojanowicz, M., Bartosiewicz, I., Bojanowska-Czajka, A., Kulisa, K., Szreder, T., Bobrowski, K., Nichiporc, H., Garcia-Reyes, J.F., Nalęcz-Jaweckie, G., Męczyńska-Wielgosz, S., and Kisala, J., Chem. Eng. J., 2019, vol. 357, p. 698.

    Article  CAS  Google Scholar 

  2. Scott, P.J., Hockley, B.G., Kung, H.F., Manchanda, R., Zhang, W., and Kilbourn, M.R., Appl. Radiat. Isot., 2009, vol. 67, no. 1, p. 88.

    Article  CAS  Google Scholar 

  3. Brinkevich, S.D., Sukonko, O.G., Chizh, G.V., and Poloiko, Yu.F., Med.-Biol. Probl. Zhizn-sti, 2014, no. 11, p. 151.

  4. Brinkevich, S.D., Tugai, O.V., and Nevzorov, D.I., High Energy Chem., 2019, vol. 53, no. 4, p. 300.

    Article  CAS  Google Scholar 

  5. Brinkevich, S., Pires, L.P., Portilho, F.L., and Santos-Oliveira, R., Curr. Radiopharm., 2018, vol. 11, p. 69.

    Article  CAS  Google Scholar 

  6. Walters, L.R., Martin, K.J., Jacobson, M.S., Hung, J.C., and Mosman, E.A., J. Nucl. Med. Technol., 2012, vol. 40, no. 1, p. 52.

    Article  Google Scholar 

  7. Brinkevich, S.D. and Tugai, O.V., High Energy Chem., 2020, vol. 54, no. 1, p. 51.

    Article  Google Scholar 

  8. Joszai, I., Svidro, M., and Pótári, N., Appl. Radiat. Isot., 2019, vol. 146, p. 78.

    Article  CAS  Google Scholar 

  9. Búriová, E., Macášek, F., Melichar, F., Kropá, M., and Procházka, L., J. Radioanal. Nucl. Chem., 2005, vol. 264, no. 3, p. 595.

    Article  Google Scholar 

  10. Brinkevich, S.D. and Shadyro, O.I., High Energy Chem., 2018, vol. 52, no. 4, p. 364.

    Article  CAS  Google Scholar 

  11. Sarathchandraprakash, N.K., Balaji, J., and Manral, K., Int. J. Innov. Res. Sci. Eng. Technol., 2014, vol. 3, no. 12, p. 18269.

    Google Scholar 

  12. Brinkevich, S.D., Kuzmuk, D.A., Sverdlov, R.L., and Shadyro, O.I., High Energy Chem., 2019, vol. 53, no. 6, p. 472.

    Article  CAS  Google Scholar 

  13. Brinkevich, S.D. and Shadyro, O.I., High Energy Chem., 2009, vol. 43, no. 6, p. 435.

    Article  CAS  Google Scholar 

  14. Dzhagatspanyan, R.V. and Filippov, M.T., Radiatsionnaya khimiya galogensoderzhashchikh organicheskikh soedinenii (Radiation Chemistry of Halogenated Organic Compounds), Moscow: Atomizdat, 1973.

  15. Petryaev, E.P. and Shadyro, O.I., Radiatsionnaya khimiya bifunktsional’nykh organicheskikh soedinenii (Radiation Chemistry of Bifunctional Organic Compounds), Minsk: Universitetskoe, 1986.

  16. Edimecheva, I.P., Kisel, R.M., Shadyro, O.I., Kazem, K., Murase, H., and Kagiya, T., J. Radiat. Res., 2005, vol. 46, no. 3, p. 319.

    Article  CAS  Google Scholar 

  17. Xing, W., Yin, M., Lv, Q., Hu, Y., Liu, C., and Zhang, J., Rotating Electrode Methods and Oxygen Reduction Electrocatalysts, Xing, W., Yin, G., Zhang, J., Eds., Amsterdam: Elsevier, 2014, p. 1.

    Google Scholar 

  18. Adams, G.E. and Willson, R.L., Trans. Faraday Soc., 1969, vol. 65, p. 2981.

    Article  CAS  Google Scholar 

  19. Müller, S.N., Batra, R., Senn, M., Giese, B., Kisel, M., and Shadyro, O., J. Am. Chem. Soc., 1997, vol. 119, no. 12, p. 2795.

    Article  Google Scholar 

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Authors and Affiliations

  1. Belarusian State University, 220030, Minsk, Belarus

    S. D. Brinkevich, O. V. Tuhai, A. A. Sladkova & O. I. Shadyro

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  1. S. D. Brinkevich
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  2. O. V. Tuhai
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  3. A. A. Sladkova
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  4. O. I. Shadyro
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Correspondence to S. D. Brinkevich.

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Translated by V. Makhlyarchuk

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Brinkevich, S.D., Tuhai, O.V., Sladkova, A.A. et al. Radiation-Induced Transformations of 2-Fluoroethanol in Aqueous Solutions. High Energy Chem 54, 455–461 (2020). https://doi.org/10.1134/S001814392006003X

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  • DOI: https://doi.org/10.1134/S001814392006003X

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