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Development of a Biodegradable Polymer Based on High-Molecular-Weight Polylactide for Medicine and Agriculture: Mechanical Properties and Biocompatibility

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Abstract

The efficiency of controlled drug release systems is largely determined by the properties of the matrix material. Our research team developed a process for production of biodegradable polymer films based on high-molecular-weight polylactide with properties necessary for medical and agricultural applications. A process for incorporation of drugs (gentamicin sulfate, lincomycin hydrochloride, cefotaxime) into high-molecular-weight polylactide films was developed. The mechanical properties and biocompatibility of the obtained polymers were studied. The films based on high-molecular-weight polylactide were found to have high strength characteristics (yield strength of about 49 MPa, tensile strength of 54 MPa). With increasing drug concentration, the strength characteristics of polymer films linearly decrease. The biocompatibility of the polymers was demonstrated on both cell cultures and implantation into animal models.

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REFERENCES

  1. Zaidi, S.A., Drug Deliv., 2016, vol. 23, pp. 2262–2271.

    CAS  PubMed  Google Scholar 

  2. Peres, C., Matos, A.I., Conniot, J., et al., Acta Biomater., 2017, vol. 48, pp. 41–57.

    Article  CAS  Google Scholar 

  3. Sullivan, M.P., McHale, K.J., Parvizi, J., et al., Bone Joint. J., 2014, vol. 96, pp. 569–573.

    Article  Google Scholar 

  4. Vu, K.D., Hollingsworth, R.G., Leroux, E., et al., Food Res. Int., 2011, vol. 44, pp. 198–203.

    Article  CAS  Google Scholar 

  5. Baikin, A.S., Kaplan, M.A., Nasakina, E.O., et al., Dokl. Chem., 2019, vol. 489, no. 2, pp. 261–263.

    Article  CAS  Google Scholar 

  6. Sevost’yanov, M.A., Nasakina, E.O., Baikin, A.S., et al., Perspekt. Mater., 2018, no. 11, pp. 39–49.

  7. Shtil’man, M.I., Polimery mediko-biologicheskogo naznacheniya (Medical and Biological Polymers), Moscow: Akademkniga, 2006.

  8. Bukharova, T.B., Antonov, E.N., Popov, V.K., et al., Bull. Exp. Biol. Med., 2010, vol. 149, pp. 148–153.

    Article  CAS  Google Scholar 

  9. Li, Z., Jiang, Z., Zhao, L., et al., Mater. Sci. Eng. C, 2017, vol. 81, pp. 443–451.

    Article  CAS  Google Scholar 

  10. Ramphul, H., Bhaw-Luximon, A., and Jhurry, D., Carbohydr. Res., 2017, vol. 178, pp. 238–250.

    Article  CAS  Google Scholar 

  11. Sevostyanov, M.A., Baikin, A.S., Shatova, L.A., et al., Dokl. Chem, 2018, vol. 482, pp. 204–206.

    Article  CAS  Google Scholar 

  12. Garmash, S.A., Smirnova, V.S., Karp, O.E., et al., J. Environ. Radioact., 2014, vol. 127, pp. 163–170.

    Article  CAS  Google Scholar 

  13. Sevost'yanov, M.A., Nasakina, E.O., Baikin, A.S., et al., J. Mater. Sci. Mater. Med., 2018, vol. 29, p. 33.

    Article  Google Scholar 

  14. Ramot, Y., Haim-Zada, M., Domb, A.J., et al., Adv. Drug. Deliv. Rev., 2016, vol. 107, pp. 153–162.

    Article  CAS  Google Scholar 

  15. Farah, S., Anderson, D.G., and Langer, R., Adv. Drug. Deliv. Rev., 2016, vol. 107, pp. 367–392.

    Article  CAS  Google Scholar 

Download references

Funding

This study was performed within the State assignment no. 075–00746–19–00 and was partially supported through a grant of the President of the Russian Federation for the State Support of Young Russian Scientists MD-2128.2020.11.

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Authors and Affiliations

  1. Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, 119991, Moscow, Russia

    M. A. Sevostyanov, M. A. Kaplan, E. O. Nasakina, A. M. Tsareva, A. A. Kolmakova,  A. G. Kolmakov & A. S. Baikin

  2. All-Russian Research Institute of Phytopatology, 143050, Bol’shie Vyazemy, Moscow oblast, Russia

    M. A. Sevostyanov, S. V. Gudkov & A. P. Glinushkin

  3. Ugresha Branch, Dubna State University, 140090, Dzerzhinsky, Moscow oblast, Russia

    M. A. Sevostyanov

  4. Voronezh State Technical University, 394036, Voronezh, Russia

    L. A. Shatova

  5. Institute of Cell Biophysics, Russian Academy of Sciences, 142290, Pushchino, Moscow oblast, Russia

    E. V. Karaduleva

  6. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290, Pushchino, Moscow oblast, Russia

    A. V. Kulikov

  7. Prokhorov General Physics Institute, Russian Academy of Sciences, 117942, Moscow, Russia

    R. M. Sarimov, A. V. Shkirin & S. V. Gudkov

  8. Lobachevsky State University of Nizhny Novgorod, 603105, Nizhny Novgorod, Russia

    S. V. Gudkov

Authors
  1. M. A. Sevostyanov
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  2. M. A. Kaplan
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  3. E. O. Nasakina
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  4. L. A. Shatova
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  5. A. M. Tsareva
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  6. A. A. Kolmakova
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  7. E. V. Karaduleva
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  8. A. V. Kulikov
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  9. R. M. Sarimov
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  10. A. V. Shkirin
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  11. S. V. Gudkov
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  12. A. P. Glinushkin
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  13. A. G. Kolmakov
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  14. A. S. Baikin
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Corresponding author

Correspondence to M. A. Sevostyanov.

Additional information

Translated by Z. Svitanko

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Sevostyanov, M.A., Kaplan, M.A., Nasakina, E.O. et al. Development of a Biodegradable Polymer Based on High-Molecular-Weight Polylactide for Medicine and Agriculture: Mechanical Properties and Biocompatibility. Dokl Chem 490, 36–39 (2020). https://doi.org/10.1134/S0012500820020044

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  • DOI: https://doi.org/10.1134/S0012500820020044

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