Skip to main content
Log in

Comparison of the Effect on Heart Rate Variability for Modeling Septoplasty and Modeling Deprivation of the Olfactory Analyzer in Rats

  • Published:
Doklady Biological Sciences Aims and scope Submit manuscript

Abstract

Modeling septoplasty and modeling sensory deprivation of the olfactory analyzer in rats were compared for the effect on the frequency domain of heart rate variability (HRV). Bulbectomy provoked more pronounced changes in HRV as compared with septoplasty simulation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1.
Fig. 2.

REFERENCES

  1. Kastyro, I.V., Popadyuk, V.I., Reshetov, I.V., Kostyaeva, M.G., Dragunova, S.G., Kosyreva, T.F., Khamidulin, G.V., and Shmaevsky, P.E., Changes in the time-domain of heart rate variability and corticosterone after surgical trauma to the nasal septum in rats, Dokl. Biochem. Biophys., 2021, vol. 499, pp. 247–250.

    Article  CAS  PubMed  Google Scholar 

  2. Kostyaeva, M.G., Kastyro, I.V., Yunusov, T.Yu., Kolomin, T.A., Torshin, V.I., Popadyuk, V.I., Draguno-va, S.G., Shilin, S.S., Kleiman, V.K., Slominsky, P.A., and Teplov, A.Y., Protein p53 expression and dark neurons in rat hippocampus after experimental septoplasty simulation, Mol. Genet., Microbiol. Virol., 2022, vol. 37, no. 1, pp. 19–24.

    Article  CAS  Google Scholar 

  3. Van Egmond, M.M.H.T., Rovers, M.M., Hannink, G., Hendriks, C.T.M., and van Heerbeek, N., Septoplasty with or without concurrent turbinate surgery versus non-surgical management for nasal obstruction in adults with a deviated septum: A pragmatic, randomised controlled trial, Lancet, 2019, vol. 394, no. 10195, pp. 314–321.

    Article  PubMed  Google Scholar 

  4. Kalmykov, I.K., Popadyuk, V.I., Ermakova, N.V., Kleyman, V.K., Shalamov, K.P., Efimenkov, I.O., Dyachenko, Yu.E., Sharipova, N.R., Sedelnikova, A.D., Gordeev, D.V., Torshin, V.I., and Kastyro, I.V., Influence of the choice of anesthetic aid on changes in the frequency range of heart rate variability during septoplasty in the early postoperative period, Russ. Rhinol., 2022, vol. 30, no. 3, pp. 169–177.

    Google Scholar 

  5. Dąbrowska‑Bień, J., Skarżyński, P.H., Gwizdalska, I., Łazęcka, K., and Skarżyńsk, H., Complications in septoplasty based on a large group of 5639 patients, Eur. Arch. Oto-Rhino-Laryngol., 2018, vol. 275, pp. 1789–1794.

    Article  Google Scholar 

  6. Simsek T., Coskun Musaoglu I., and Uluat A. The effect of lidocaine and tramadol in nasal packs on pain after septoplasty, Eur. Arch. Oto-Rhino-Laryngol., 2019, vol. 276, no. 6, pp. 1663–1669.

    Article  Google Scholar 

  7. Kastyro, I.V., Reshetov, I.V., Popadyuk, V.I., Tor-shin, V.I., Ermakova, N.V., Karpukhina, O.V., Inozemtsev, A.N., Khamidulin, G.V., Shmaevsky, P.E., Sardarov, G.G., Gordeev, D.V., and Scopich, A.A., Studying the physiological effects of a new model of septoplasty in rats, Head Neck Russ. J., 2020, vol. 8, no. 2, pp. 33–38.

    Google Scholar 

  8. Kastyro, I.V., Inozemtsev, N., Shmaevsky, P.E., Khamidullin, G.V., Torshin, V.I., Kovalenko, A.N., Pryanikov, P.D., and Guseinov, I.I., The impact of trauma of the mucous membrane of the nasal septum in rats on behavioral responses and changes in the balance of the autonomic nervous system (pilot study), J. Phys.: Conf. Ser., 2020, vol. 1611, p. 012054.

    Google Scholar 

  9. Carod-Artal, F.J., Infectious diseases causing autonomic dysfunction, Clin. Auton. Res., 2018, vol. 28, pp. 67–81.

    Article  PubMed  Google Scholar 

  10. Ghosh, R., Roy, D, Sengupta, S., and Benito-Leon, J., Autonomic dysfunction heralding acute motor axonal neuropathy in COVID-19, J. Neurovirol., 2020, vol. 26, pp. 964–966.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Buchhorn, R., Baumann, C., and Willaschek, C., Heart rate variability in a patient with coronavirus disease 2019, Int. Cardiovasc. Forum J., 2020, p. 2020050209.

  12. Riganello, F., Chatelle, C., Schnakers, C., and Laureys, S., Heart rate variability as an indicator of nociceptive pain in disorders of consciousness?, J. Pain Symptom Manage., 2019, vol. 57, no. 1, pp. 47–56.

    Article  PubMed  Google Scholar 

  13. Dragunova, S.G., Kosyreva, T.F., Severin, A.E., Shmaevsky, P.E., Khamidulin, G.V., Popadyuk, V.I., Yudin, D.K., Yunusov, T.Y., Kleyman, V.K., Kuzne-tsov, N.D., Skopich, A.A., Kastyro, I.V., Kostyaeva, M.G., Vostrikov, A.M., Sheveleva, V.A., Antoniv, V.F., Torshin, V.I., and Ermakova, N.V., The effect of simulating sinus lifting and septoplasty on changes in the sympathetic and parasympathetic nervous systems in rats, Head Neck Russ. J., 2021, vol. 9, no. 3, pp. 43–49.

    Google Scholar 

  14. Freitas, A.E., Machado, D.G., Budni, J., Neis, V.B., Balen, G.O., Lopes, M.W., de Souza, L.F., Dafre, A.L., Leal, R.B., and Rodrigues, A.L., Fluoxetine modulates hippocampal cell signaling pathways implicated in neuroplasticity in olfactory bulbectomized mice, Behav. Brain Res., 2013, vol. 15, no. 237, pp. 176–184.

    Article  Google Scholar 

  15. Dolgalev, Al.Al., Svyatoslavov, D.S., Pout, V.A., Reshetov, I.V., and Kastyro, I.V., Effectiveness of the sequential use of plastic and titanium implants for experimental replacement of the mandibular defect in animals using preliminary digital design, Dokl. Biochem. Biophys., 2021, vol. 496, pp. 36–39.

    Article  CAS  PubMed  Google Scholar 

  16. Agadzhanyan, N.A., Batotsyrenova, T.E., Severin, A.E., Semenov, Y.N., Sushkova, L.T., and Gomboeva, N.G., Comparison of specific features of the heart rate variability in students living in regions with different natural and climatic conditions, Human Physiol., 2007, vol. 33, no. 6, pp. 715–719.

    Article  Google Scholar 

  17. Takabatake, N., Nakamura, H., Minamihaba, O., Inage, M., Inoue, S., Kagaya, S., Michiyasu, Y., and Tomoike, H., A novel pathophysiological phenomenon in cachexic patients with obstructive pulmonary disease: the relationship between the circadian rhythm of circulating leptin and very low frequency component of heart rate variability, Am. J. Respir. Crit. Care Med., 2001, vol. 163, pp. 1314–1319.

    Article  CAS  PubMed  Google Scholar 

  18. Pinchasov, G. and Juodzbalys, G., Graft-free sinus augmentation procedure: a literature review, J. Oral Maxillofacial Res., 2014, vol. 5, no. 1, p. e1.

    Article  Google Scholar 

  19. Sturman, O., Germain, P.L., and Bohacek, J., Exploratory rearing: a context- and stress-sensitive behavior recorded in the open-field test, Stress, 2018, vol. 21, no. 5, pp. 443–452.

    Article  PubMed  Google Scholar 

  20. Eckberg, D.L., Sympathovagal balance: a critical appraisal, Circulation, 1997, vol. 96, pp. 3224–3232.

    Article  CAS  PubMed  Google Scholar 

  21. Billman, G.E., The LF/HF ratio does not accurately measure cardiac sympatho-vagal balance, Front. Physiol., 2013, vol. 4, p. 26.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Kang, J.H., Kim, J.K., Hong, S.H., Lee, C.H., and Choi, B.Y., Heart rate variability for quantification of autonomic dysfunction in fibromyalgia, Ann. Rehabil. Med., 2016, vol. 40, no. 2, pp. 301–309.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Kastyro, I.V., Reshetov, I.V., Khamidulin, G.V., Shmaevsky, P.E., Karpukhina, O.V., Inozemtsev, A.N., Torshin, V.I., Ermakova, N.V., and Popadyuk, V.I., The effect of surgical trauma in the nasal cavity on the behavior in the open field and the autonomic nervous system of rats, Dokl. Biochem. Biophys., 2020, vol. 492, pp. 121–123.

    Article  CAS  PubMed  Google Scholar 

  24. Popadyuk, V.I., Kastyro, I.V., Ermakova, N.V., and Torshin, V.I., Septoplasty and tonsillectomy: acute stress response as a measure of effectiveness of local anesthetics, Vestn. Otorinolaringol., 2016, vol. 81, no. 3, pp. 7–11.

    Article  CAS  PubMed  Google Scholar 

  25. Alvites, R.D., Caseiro, A.R., Pedrosa, S.S., Branquinho, M.E., Varejão, A.S.P., and Maurício, A.C., The nasal cavity of the rat and mouse-source of mesenchymal stem cells for treatment of peripheral nerve injury, Anat. Rec., 2018, vol. 301, pp. 1678–1689. https://doi.org/10.1002/ar.23844

    Article  CAS  Google Scholar 

  26. Aragoneses Lamas, J.M., Gómez Sánchez, M., Cuadrado González, L., Suárez García, A., and Aragoneses Sánchez, J., Vertical bone gain after sinus lift procedures with beta-tricalcium phosphate and simultaneous implant placement—a cross-sectional study, Medicina, 2020, vol. 56, p. 609

    Article  PubMed  PubMed Central  Google Scholar 

  27. Dard, M., Animal models for experimental surgical research in implant dentistry, in Implant Dentistry Research Guide: Basic, Transitional, and Experimental Clinical Research, Ballo, A., Ed., New York: Nova Sci., 2012, pp. 167–190.

    Google Scholar 

  28. Goebel, M.U., Mills, P.J., Irwin, M.R., and Zieg-ler, M.G., Interleukin-6 and tumor necrosis factor-alpha production after acute psychological stress, exercise, and infused isoproterenol: differential effects and pathways, Psychosom. Med., 2000, vol. 62, pp. 591–598.

    Article  CAS  PubMed  Google Scholar 

  29. Kim, E.J., Pellman, B., and Kim, J.J., Stress effects on the hippocampus: a critical review, Learn Mem., 2015, vol. 22, no. 9, pp. 411–416.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Mello Lima, J.F., Melo de Matos, J.D., Santos, Í.K.S., de Oliveira, A.J.A.G., de Vasconcelos, J.E.L., Zoghe-ib, L.V., and Sartorelli de Castro, D., Maxillary sinus lift surgery techniques: a literature review maxillary sinus lift surgery techniques: a literature review maxillary sinus lift surgery techniques: a literature review, Int. J. Adv. Res., 2017, vol. 5, no. 8, pp. 832–844.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to A. G. Mnatsakanyan.

Ethics declarations

Conflict of interests. The authors declare that they have no conflicts of interest.

Statement on the welfare of animals. Experiments with rats were performed in compliance with the Guidance for Works with Experimental Animals (1984) and the European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes (1986). The study protocol was approved by the Ethics Committee at the Peoples’ Friendship University of Russia (Minutes no. 1 dated September 18, 2020).

Additional information

Translated by T. Tkacheva

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mnatsakanyan, A.G., Korolev, A.G., Tsymbal, A.A. et al. Comparison of the Effect on Heart Rate Variability for Modeling Septoplasty and Modeling Deprivation of the Olfactory Analyzer in Rats. Dokl Biol Sci 509, 107–111 (2023). https://doi.org/10.1134/S0012496623700291

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0012496623700291

Keywords:

Navigation