Skip to main content
SpringerLink
Log in

The ability to solve elementary logic tasks in mice with the knockout of sodium–calcium exchanger gene 2 (NCX2)

  • Physiology
  • Published:
Doklady Biological Sciences Aims and scope Submit manuscript

Abstract

Mice with a knockout of the sodium–calcium exchanger 2 (NCX2) gene were statistically significantly more successful than wild-type controls in the solution of two cognitive tasks, the test for the capacity to extrapolate the direction of the stimulus movement and the “puzzle-box” test for the capacity to find a hidden route to safe environment, which were based on food and aversive motivations, respectively. In both tests, the success of task solution was based on the animal’s ability to use the object’s “permanence” rule (according to J. Piaget). The data confirm that the knockout of this gene, which is accompanied by modulation of the temporal pattern of calcium membrane flux, also induces changes in mouse CNS plasticity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Golibrodo, V.A., Perepelkina, O.V., Lil’p, I.G., et al., Zh. Vyssh. Nervn. Deyat., 2014, vol. 64, no. 6, pp. 639–645.

    CAS  Google Scholar 

  2. Perepelkina, O.V., Golibrodo, V.A., Lil’p, I.G., et al., Dokl. Biol. Sci., 2015, vol. 460, no. 5, pp. 52–56.

    Article  CAS  PubMed  Google Scholar 

  3. Ben Abdallah, N.M., Fuss, J., Trusel, M., et al., Exp. Neurol., 2011, vol. 227, p. 1016, doi 10.1016/jexpneurol.2010.09.008.

    Article  Google Scholar 

  4. Ennaceur, A., Behav. Brain Res., 2010, vol. 215, no. 2, p. 1016, doi 10.1016/jbbr.2009.12.036.

    Article  Google Scholar 

  5. Ennaceur, A., Michalikova, S., Bradford, A., et al., Behav. Brain Res., 2005, vol. 159, no. 2, pp. 247–266.

    Article  CAS  PubMed  Google Scholar 

  6. Jeon, D., Yang, Y.M., Jeong, M.J., et al., Neuron, 2003, vol. 38, no. 6, pp. 965–976.

    Article  CAS  PubMed  Google Scholar 

  7. Li, X.F., Kiedrowski, L., Tremblay, F., et al., J. Biol. Chem., 2006, vol. 281, no. 10, pp. 6273–6282.

    Article  CAS  PubMed  Google Scholar 

  8. Luedke, A.C., Boucher, P.O., Niel, L., et al., Behav. Brain Res., 2013, vol. 239, p. 1016, doi 10.1016/jbbr.2012.10.056.

    Article  Google Scholar 

  9. Naude, P.J., Dobos, N., van der Meer, D., et al., Behav. Brain Res., 2014, vol. 258, p. 1016, doi 10.1016/jbbr.2013.10.006.

    Article  Google Scholar 

  10. Powell, S.B., Geyer, M.A., Gallagher, D., et al., Behav. Brain Res., 2004, vol. 152, no. 2, pp. 341–349.

    Article  PubMed  Google Scholar 

  11. Reynolds, S., Urruela, M., and Devine, D.P., Autism Res, 2013, vol. 6, no. 5, p. 1002, doi 10.1002/aur.1298.

    Google Scholar 

  12. Zucca, P., Milos, N., and Vallortigara, G., Anim. Cogn., 2007, vol. 10, pp. 243–258.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Moscow State University, Moscow, 199991, Russia

    I. I. Poletaeva, O. V. Perepelkina, O. S. Boyarshinova, V. A. Golibrodo & I. G. Lilp

  2. Institute of Anatomy, University of Zürich, Zürich, Switzerland

    H.-P. Lipp

  3. School of Laboratory Medicine, Kwazulu-Natal University, Durban, South Africa

    H.-P. Lipp

  4. Center for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon, Republic of Korea

    Hee Sup Shin

Authors
  1. I. I. Poletaeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. O. V. Perepelkina
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. O. S. Boyarshinova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. V. A. Golibrodo
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. I. G. Lilp
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. H.-P. Lipp
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Hee Sup Shin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to I. I. Poletaeva.

Additional information

Original Russian Text © I.I. Poletaeva, O.V. Perepelkina, O.S. Boyarshinova, V.A. Golibrodo, I.G. Lilp, H.-P. Lipp, Hee Sup Shin, 2016, published in Doklady Akademii Nauk, 2016, Vol. 469, No. 3, pp. 375–378.

The article was translated by the authors.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Poletaeva, I.I., Perepelkina, O.V., Boyarshinova, O.S. et al. The ability to solve elementary logic tasks in mice with the knockout of sodium–calcium exchanger gene 2 (NCX2). Dokl Biol Sci 469, 159–162 (2016). https://doi.org/10.1134/S0012496616040098

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0012496616040098

Search

Navigation