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Human herpes simplex virus: Life cycle and development of inhibitors

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Abstract

WHO reports that 90% of human population is infected by different types of herpesviruses, which develop latency or cause oral and genital herpes, conjunctivitis, eczema herpeticum, and other diseases. Herpesvirus almost always accompanies HIV-infection and complicates AIDS treatment. Herpes simplex virus type 1 is one of the most wide spread viruses from the Herpesviridae family. HSV virion, genome structure, replication mechanisms, antiherpes drug development strategies, including design of prodrugs, and mutations causing ACV-resistance in clinical HSV isolates are discussed in this review.

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Abbreviations

ACV:

acyclovir

AraA:

adenine arabinoside

BVDU:

(E)-5-(2-bromovinyl)-2′-deoxyuridine (brivudin)

CMV:

cytomegalovirus

DAI:

DNA-dependent activator of interferon regulatory factor

GCV:

ganciclovir

HFC-1:

host cell factor 1

HHV-6A, 6B, 7, 8:

human herpes virus

HIV:

human immunodeficiency virus

HpACV:

acyclovir H-phosphonate

HSV-1:

herpes simplex virus-1

IFI16:

γ-interferon-inducible protein

IRF-3:

interferon regulatory factor 3

LAT:

latency associated transcript

ND-10:

nuclear domain 10

PCV:

penciclovir

PFA:

phosphonoformic acid

PMEA:

9-(2-phosphonylmethoxyethyl)-adenine

RR:

ribonucleotide reductase

VZV:

varicella zoster virus

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  1. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, 119991, Moscow, Russia

    M. K. Kukhanova, A. N. Korovina & S. N. Kochetkov

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  1. M. K. Kukhanova
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  2. A. N. Korovina
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  3. S. N. Kochetkov
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Original Russian Text © M. K. Kukhanova, A. N. Korovina, S. N. Kochetkov, 2014, published in Uspekhi Biologicheskoi Khimii, 2014, Vol. 54, pp. 457–494.

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Kukhanova, M.K., Korovina, A.N. & Kochetkov, S.N. Human herpes simplex virus: Life cycle and development of inhibitors. Biochemistry Moscow 79, 1635–1652 (2014). https://doi.org/10.1134/S0006297914130124

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