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Role of acidosis, NMDA receptors, and acid-sensitive ion channel 1a (ASIC1a) in neuronal death induced by ischemia

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Abstract

This review collects data on the influence of intracellular and extracellular acidosis on neuronal viability and the effect of acidosis on neuronal damage progressing under brain ischemia/hypoxia. Particular attention is devoted to the involvement of ionotropic glutamic receptors and acid-sensitive ion channel 1a in these processes.

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Abbreviations

ASIC1a:

acid-sensitive ion channel 1a

CaMKII:

Ca2+/calmodulin-dependent protein kinase II

CGNs:

cultured granular neurons

EIPA:

5-(N-ethyl-N-isopropyl)-amiloride

NMDA:

N-methyl-D-aspartate

NMDARs:

NMDA-subtype of glutamate receptors incorporating NR2B-subunit

ROS:

reactive oxygen species

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Authors and Affiliations

  1. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991, Moscow, Russia

    N. K. Isaev, E. Y. Plotnikov, T. G. Khryapenkova, D. N. Silachev & D. B. Zorov

  2. Brain Research Department, Scientific Center of Neurology, Russian Academy of Medical Sciences, Pereulok Obukha 5, 105064, Moscow, Russia

    N. K. Isaev & E. V. Stelmashook

  3. Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119992, Moscow, Russia

    E. R. Lozier & Y. V. Doludin

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  1. N. K. Isaev
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  2. E. V. Stelmashook
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Correspondence to N. K. Isaev.

Additional information

Published in Russian in Biokhimiya, 2008, Vol. 73, No. 11, pp. 1461–1466.

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Isaev, N.K., Stelmashook, E.V., Plotnikov, E.Y. et al. Role of acidosis, NMDA receptors, and acid-sensitive ion channel 1a (ASIC1a) in neuronal death induced by ischemia. Biochemistry Moscow 73, 1171–1175 (2008). https://doi.org/10.1134/S0006297908110011

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  • DOI: https://doi.org/10.1134/S0006297908110011

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