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Preparation and Properties of Complexes Based on Chitosan-Ag Nanocomposite and Cephalosporin Antibiotics

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Abstract

Aggregatively stable, positively charged (~45 mV) chitosan-Ag nanocomposites with a spherical shape and size up to 60.0 nm were synthesized by the “green chemistry” method via the chemical reduction of silver nitrate with chitosan. Chitosan-Ag/ceftriaxone and chitosan-Ag/cefotaxime complexes containing up to 1.06 ± 0.01 and 1.29 ± 0.03 mg antibiotic/mg chitosan-Ag respectively were obtained. It was found that an increase in the ceftriaxone : chitosan-Ag weight ratio in the reaction mixture from 0.5 to 1.25 leads to an increase in the efficiency of antibiotic binding to nanoparticles from 7.2 ± 0.2 to 71.7 ± 0.2%. With an increase in the cefotaxime : chitosan-Ag ratio in the reaction mixture from 0.5 to 10, the antibiotic binding efficiency decreases from 66.2 ± 1.5 to 13.0 ± 0.7%. The formation of chitosan-Ag/antibiotic complexes was confirmed by infrared (IR) spectroscopy. The effectiveness of the use of the chitosan-Ag/cefotaxime complexes against antibiotic-resistant strains of Escherichia coli and Staphylococcus aureus was established.

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Funding

This work was carried out with the financial support of the Belarusian Republican Foundation for Fundamental Research (contract X20SRBG-002) and grant no. 337-00-00612/2019-09/02.

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Authors and Affiliations

  1. Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus, 220141, Minsk, Republic of Belarus

    A. N. Kraskouski, V. V. Nikalaichuk, K. S. Hileuskaya, V. I. Kulikouskaya & V. E. Agabekov

  2. Vyshelessky Institute of Experimental Veterinary Medicine, 220063, Minsk, Republic of Belarus

    E. A. Stepanova & I. I. Kuzminski

  3. University of Belgrade, 11000, Belgrade, Republic of Serbia

    N. Opavski

Authors
  1. A. N. Kraskouski
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  2. V. V. Nikalaichuk
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  3. K. S. Hileuskaya
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  4. V. I. Kulikouskaya
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  5. E. A. Stepanova
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  8. V. E. Agabekov
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Correspondence to A. N. Kraskouski.

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The authors declare that they have no conflicts of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.

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Kraskouski, A.N., Nikalaichuk, V.V., Hileuskaya, K.S. et al. Preparation and Properties of Complexes Based on Chitosan-Ag Nanocomposite and Cephalosporin Antibiotics. Appl Biochem Microbiol 58, 136–142 (2022). https://doi.org/10.1134/S0003683822020120

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  • DOI: https://doi.org/10.1134/S0003683822020120

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