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Monoclonal antibodies to tumor necrosis factor-alpha influence metabolic activity in lymphocytes under conditions of chronic ethanol consumption

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Abstract

In Wistar rats consuming ethanol for 10 weeks (the Lieber-De Carli liquid diet), dose-dependent effects of infliximab (monoclonal antibody to tumor necrosis factor alpha, TNFα) have been demonstrated. The 10-day course of intraperitoneal injections of infliximab (1 or 10 mg/kg body weight) to rats exposed to chronic ethanol consumption caused changes in the concentrations of free amino acids and their nitrogencontaining metabolites, and also promoted the development of amino acid imbalance in liver lymphocytes. Treatment of ethanol consuming animals with infliximab increased in a dose-dependent manner the pool of free amino acids and the amount of their nitrogen-containing metabolites in lymphocytes. Adaptive changes in the system of the transport of amino acids and other nutrients in the liver lymphocytes are one of the possible mechanisms associated with TNFα inactivation.

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Authors and Affiliations

  1. Grodno State Medical University, ul. Gorkogo 80, Grodno, 230003, Belarus

    M. V. Haretskaya & V. M. Sheibak

Authors
  1. M. V. Haretskaya
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  2. V. M. Sheibak
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Correspondence to M. V. Haretskaya.

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Original Russian Text © M.V. Haretskaya, V.M. Sheibak, 2014, published in Biomeditsinskaya Khimiya.

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Haretskaya, M.V., Sheibak, V.M. Monoclonal antibodies to tumor necrosis factor-alpha influence metabolic activity in lymphocytes under conditions of chronic ethanol consumption. Biochem. Moscow Suppl. Ser. B 8, 47–52 (2014). https://doi.org/10.1134/S1990750814010065

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