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Influence of Loranthus micranthus against STZ-Induced Neurobehavioral Deficits in Diabetic Rats

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Abstract

Loranthus micranthus (LM) is used in the treatment of diabetes and mental disorders in Nigerian folklore medicine. We studied the short-term memory behavior as well as the activity of acetylcholinesterase, antioxidant status and glycolytic flux in cerebrum and cerebellum of diabetic rats treated with LM extract. Histopathological evaluation was used to assess the level of damage on brain tissue due to diabetes complications. Treatment with LM improved short-term memory behavior, significantly reduced the levels of lipid peroxidation (LPO), increased glutathione (GSH) levels and enhanced the activities of antioxidant enzymes. Activities of glucose metabolism enzymes were augmented while acetylcholinesterase (AChE) activity was reduced by LM treatment compared with the untreated diabetic group. Histopathology evaluation revealed the possible influence of LM in reversing diabetes-induced damage in brain tissue. Further studies are required to accentuate the potentials of LM extract in assuaging diabetes-induced neurological deficits.

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Funding

This work was supported by FUNAI Institutional based TETFUND grant with code FUNAI/FST/14/B2/022 awarded to Dr. Azubuike Ebokaiwe.

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Authors and Affiliations

  1. Department of Chemistry/Biochemistry and Molecular Biology, Alex-Ekwueme Federal University Ndufu-Alike, P.O. Box 1010, Abakaliki, Nigeria

    Azubuike P. Ebokaiwe & Obinna Osuji

  2. Department of Anatomy, School of Health and Health Technology, Federal University of Technology, Akure, Nigeria

    Omamuyovwi M. Ijomone

  3. Department of Biochemistry, Faculty of Applied Sciences, KolaDaisi University, Ibadan, Nigeria

    Sharon O. Osawe

  4. Department of Biology/Microbiology/Biotechnology, Alex-Ekwueme Federal University, Ndufu-Alike, Nigeria

    Moses Alo

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  1. Azubuike P. Ebokaiwe
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  2. Omamuyovwi M. Ijomone
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Correspondence to Azubuike P. Ebokaiwe.

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Ethical approval. All animals received humane care according to the criteria outlined in the “Guide for the Care and Use of Laboratory Animals” prepared by the National Academy of Science (NAS) and published by the National Institute of Health. The experiment was performed in accordance with the guidelines and approval of institutional animal ethics committee AE-FUNA.

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Ebokaiwe, A.P., Ijomone, O.M., Osawe, S.O. et al. Influence of Loranthus micranthus against STZ-Induced Neurobehavioral Deficits in Diabetic Rats. Neurochem. J. 13, 283–294 (2019). https://doi.org/10.1134/S1819712419030061

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