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Synthesis, Antitubercular Activity, and Molecular Docking Studies of Novel 2-(4-Chlorobenzylamino)-4-(cyclohexylmethylamino)-pyrimidine-5-carboxamides

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Abstract

A novel series of 2-(4-chlorobenzylamino)-4-(cyclohexylmethylamino)-pyrimidine-5-carboxamide derivatives are synthesized and their structures are confirmed by 1H and 13C NMR, and MS spectral data. The compounds are screened for their antitubercular activity, and those with aryl moiety 7o, 7q, and 7r demonstrate potent activity against Mycobacterium tuberculosis. Docking studies suggest a mode of interaction of the products with the binding site of enoyl-CoA hydratase demonstrating that the target compounds were potential anti-TB agents.

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Authors and Affiliations

  1. Department of Chemistry, Koneru Lakshmaiah Education Foundation, Green Fields, Vaddeswaram, Guntur, 522502, India

    B. Srinu, G. Kali Charan, E. Srinivas, Ch. P. Koteswara Rao & S. Naresh Varma

  2. Department of Pharmaceutical Chemistry, Gurunanak Institutions Technical Campus, School of Pharmacy, Hyderabad, 501506, India

    R. Parameshwar

  3. Department of Pharmaceutical Chemistry, Guruktupa Institute of Pharmacy, Maharashtra, 431129, India

    J. N. Narendra Sharath Chandra

Authors
  1. B. Srinu
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  2. R. Parameshwar
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  3. G. Kali Charan
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  4. E. Srinivas
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  5. Ch. P. Koteswara Rao
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  6. J. N. Narendra Sharath Chandra
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Correspondence to S. Naresh Varma.

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Srinu, B., Parameshwar, R., Kali Charan, G. et al. Synthesis, Antitubercular Activity, and Molecular Docking Studies of Novel 2-(4-Chlorobenzylamino)-4-(cyclohexylmethylamino)-pyrimidine-5-carboxamides. Russ J Gen Chem 89, 836–843 (2019). https://doi.org/10.1134/S1070363219040327

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  • DOI: https://doi.org/10.1134/S1070363219040327

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