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Transgenerational genomic instability in the first generation offspring of mice exposed to low-intensity red and near-infrared irradiation in vivo

  • Biophysics of Complex Systems
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Abstract

Transgenerational genomic instability in the first generation offspring of mice exposed to lowintensity infrared laser (632.8 nm) and light-emitting-diode infrared irradiation (850 nm) was investigated in vivo. It was found that the level of spontaneous damage in bone marrow according to the micronucleus test, the level of reactive oxygen species in whole blood, and the mass index of lymphoid organs in all of the descendants of irradiated mice did not increase. After additional X-ray exposure of the progeny at a dose rate of 1.5 Gy, a decrease in the level of damage and the absence of an adaptive response were revealed upon testing according to “radiosensitivity” and the radiation-induced adaptive-response scheme (0.1 + 1.5 Gy), respectively, compared to the descendants of nonirradiated mice. The rate of tumor growth in the offspring of irradiated mice did not differ from that in the descendants of nonirradiated mice, although inhibition of the tumor growth rate was observed in their irradiated parents. The survival rate after irradiation at a dose rate of 6.5 Gy did not differ from both the parents and the control.

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Abbreviations

IRL:

infrared light

ROS:

reactive oxygen species

PCPE:

polychromatophylic erythroblasts

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Authors and Affiliations

  1. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290, Russia

    S. I. Zaichkina, A. R. Dyukina, O. M. Rozanova, S. P. Romanchenko, N. B. Simonova & S. S. Sorokina

  2. Institute of Photon Technologies, Crystallography and Photonics Federal Scientific Research Center, Russian Academy of Sciences, Troitsk, Moscow, 142190, Russia

    V. I. Yusupov & V. N. Bagratashvili

Authors
  1. S. I. Zaichkina
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  2. A. R. Dyukina
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  3. O. M. Rozanova
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  4. S. P. Romanchenko
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  5. N. B. Simonova
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  6. S. S. Sorokina
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  7. V. I. Yusupov
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  8. V. N. Bagratashvili
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Corresponding author

Correspondence to S. I. Zaichkina.

Additional information

Original Russian Text © S.I. Zaichkina, A.R. Dyukina, O.M. Rozanova, S.P. Romanchenko, N.B. Simonova, S.S. Sorokina, V.I. Yusupov, V.N. Bagratashvili, 2017, published in Biofizika, 2017, Vol. 62, No. 5, pp. 1016–1022.

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Zaichkina, S.I., Dyukina, A.R., Rozanova, O.M. et al. Transgenerational genomic instability in the first generation offspring of mice exposed to low-intensity red and near-infrared irradiation in vivo. BIOPHYSICS 62, 836–841 (2017). https://doi.org/10.1134/S0006350917050244

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  • DOI: https://doi.org/10.1134/S0006350917050244

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