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Journal of Clinical Microbiology, September 2005, p. 4911-4913, Vol. 43, No. 9
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.9.4911-4913.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Molecular Evidence of Recurrent Histoplasmosis with 9-Year Latency in a Patient with Addison's Disease

Tai-Chung Tseng,1 Shwu-Jen Liaw,2,4 Cheng-Hsiang Hsiao,3 Cheng-Yi Wang,1 Li-Na Lee,1,2 Tien-Shang Huang,1 and Po-Ren Hsueh1,2*

Departments of Internal Medicine,1 Laboratory Medicine,2 Pathology, National Taiwan University Hospital,3 School of Medical Technology, National Taiwan University College of Medicine, Taipei, Taiwan4

Received 6 April 2005/ Returned for modification 22 April 2005/ Accepted 17 May 2005

We present a case of fatal histoplasmosis in a patient with Addison's disease and long-term use of corticosteroid. The patient acquired Histoplasma capsulatum in China and initially presented with a laryngeal mass. He developed fulminant pneumonia and respiratory failure 9 years later. Nucleotide sequences of internal transcribed spacer regions of rRNA genes of the H. capsulatum isolate recovered from biopsied lung tissue and of the extracted fungal DNA from the laryngeal lesion were identical, indicating the recurrent nature of infection.


* Corresponding author. Mailing address: Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, 7 Chung-Shan South Road, Taipei, Taiwan. Phone: 886-2-23123456 ext. 5363. Fax: 886-2-23224263. E-mail: hsporen{at}ha.mc.ntu.edu.tw.


Journal of Clinical Microbiology, September 2005, p. 4911-4913, Vol. 43, No. 9
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.9.4911-4913.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.







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