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Journal of Clinical Microbiology, January 2005, p. 502-505, Vol. 43, No. 1
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.1.502-505.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Variation of the Polymorphic Region X of the Protein A Gene during Persistent Airway Infection of Cystic Fibrosis Patients Reflects Two Independent Mechanisms of Genetic Change in Staphylococcus aureus

Barbara C. Kahl,1* Alexander Mellmann,2 Susanne Deiwick,1 Georg Peters,1 and Dag Harmsen2

Institute of Medical Microbiology,1 Institute for Hygiene, University of Muenster, Muenster, Germany2

Received 19 June 2004/ Returned for modification 13 August 2004/ Accepted 21 September 2004

Variation of the polymorphic region of the protein A gene (spa) was observed during long-term persistence of Staphylococcus aureus in the airways of 10 cystic fibrosis patients and occurred at a rate of one genetic change every 70 months. Independent mutational events were observed eight times in 142 isolates: four deletions, two duplications of repeats, and two point mutations.

* Corresponding author. Mailing address: Institute of Medical Microbiology, University Hospital of Muenster, Domagkstr. 10, 48149 Muenster, Germany. Phone: 49-251-8355381. Fax: 49-251-8355350. E-mail: kahl{at}uni-muenster.de.

Journal of Clinical Microbiology, January 2005, p. 502-505, Vol. 43, No. 1
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.1.502-505.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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