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Journal of Bacteriology, May 2008, p. 3411-3416, Vol. 190, No. 9
0021-9193/08/$08.00+0     doi:10.1128/JB.01928-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Campylobacter jejuni CsrA Mediates Oxidative Stress Responses, Biofilm Formation, and Host Cell Invasion{triangledown}

Joshua A. Fields and Stuart A. Thompson*

Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia 30912

Received 12 December 2007/ Accepted 21 February 2008

The putative global posttranscriptional regulator csrA was mutated in Campylobacter jejuni 81-176. The csrA mutant was attenuated in surviving oxidative stress. CsrA also contributed to biofilm formation and adherence to and invasion of INT407 intestinal epithelial cells, suggesting a regulatory role for CsrA in C. jejuni pathogenesis.

* Corresponding author. Mailing address: Department of Biochemistry and Molecular Biology, Medical College of Georgia, 1459 Laney-Walker Blvd., Augusta, GA 30912. Phone: (706) 721-7277. Fax: (706) 721-6608. E-mail: stthomps{at}mcg.edu

{triangledown} Published ahead of print on 29 February 2008.

Journal of Bacteriology, May 2008, p. 3411-3416, Vol. 190, No. 9
0021-9193/08/$08.00+0     doi:10.1128/JB.01928-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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