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Journal of Bacteriology, April 2007, p. 2921-2925, Vol. 189, No. 7
0021-9193/07/$08.00+0     doi:10.1128/JB.01485-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Precise Excision and Self-Integration of a Composite Transposon as a Model for Spontaneous Large-Scale Chromosome Inversion/Deletion of the Staphylococcus haemolyticus Clinical Strain JCSC1435{triangledown}

Shinya Watanabe,1 Teruyo Ito,1,2 Yuh Morimoto,1 Fumihiko Takeuchi,1 and Keiichi Hiramatsu1,2*

Department of Infection Control Science, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, Japan,1 Department of Bacteriology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, Japan2

Received 20 September 2006/ Accepted 9 January 2007

Large-scale chromosomal inversions (455 to 535 kbp) or deletions (266 to 320 kbp) were found to accompany spontaneous loss of beta-lactam resistance during drug-free passage of the multiresistant Staphylococcus haemolyticus clinical strain JCSC1435. Identification and sequencing of the rearranged chromosomal loci revealed that ISSha1 of S. haemolyticus is responsible for the chromosome rearrangements.

* Corresponding author. Mailing address: Department of Bacteriology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, Japan 113-8421. Phone: 81-3-5802-1041. Fax: 81-3-5684-7830. E-mail: khiram06{at}med.juntendo.ac.jp.

{triangledown} Published ahead of print on 19 January 2007.

Journal of Bacteriology, April 2007, p. 2921-2925, Vol. 189, No. 7
0021-9193/07/$08.00+0     doi:10.1128/JB.01485-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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