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Journal of Bacteriology, January 2008, p. 769-771, Vol. 190, No. 2
0021-9193/08/$08.00+0     doi:10.1128/JB.01253-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

LuxS Affects Flagellar Phase Variation Independently of Quorum Sensing in Salmonella enterica Serovar Typhimurium

M. H. Karavolos,¹ D. M. Bulmer,^1, K. Winzer,^2, M. Wilson,¹ P. Mastroeni,³ P. Williams,⁴ and C. M. A. Khan^1*

Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Newcastle NE2 4HH,¹ Department of Biological Sciences, Lancaster University, Lancaster LA1 4YQ,² Centre for Veterinary Science, University of Cambridge, Cambridge CB3 0ES,³ Institute of Infection Immunity and Inflammation, Centre for Biomolecular Sciences, University Park, University of Nottingham, Nottingham NG7 RD, United Kingdom⁴

Received 3 August 2007/ Accepted 19 October 2007

LuxS catalyzes the synthesis of the quorum-sensing signaling molecule autoinducer 2. We show that in Salmonella enterica serovar Typhimurium, deletion of the luxS gene polarizes flagellar phase variation toward the more immunogenic phase 1 flagellin. This phenotype is complementable by luxS in trans but is independent of quorum-sensing signals.

Published ahead of print on 16 November 2007.

These authors have contributed equally to the work.