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Journal of Bacteriology, August 2006, p. 5650-5653, Vol. 188, No. 15
0021-9193/06/$08.00+0     doi:10.1128/JB.00323-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Arginine-Dependent Acid Resistance in Salmonella enterica Serovar Typhimurium

Jasper Kieboom1,2,{dagger} and Tjakko Abee1*

Laboratory of Food Microbiology, Wageningen University Agrotechnology and Food Sciences Group, P.O. Box 8129, 6700 EV Wageningen, The Netherlands,1 RIKILT Institute of Food Safety, P.O. Box 230, 6700 AE Wageningen, The Netherlands2

Received 6 March 2006/ Accepted 15 May 2006

Salmonella enterica serovar Typhimurium does not survive a pH 2.5 acid challenge under conditions similar to those used for Escherichia coli (J. W. Foster, Nat. Rev. Microbiol. 2:898-907, 2004). Here, we provide evidence that S. enterica serovar Typhimurium can display arginine-dependent acid resistance (AR) provided the cells are grown under anoxic conditions and not under the microaerobic conditions used for assessment of AR in E. coli. The role of the arginine decarboxylase pathway in Salmonella AR was shown by the loss of AR in mutants lacking adiA, which encodes arginine decarboxylase; adiC, which encodes the arginine-agmatine antiporter; or adiY, which encodes an AraC-like regulator. Transcription of adiA and adiC was found to be dependent on AdiY, anaerobiosis, and acidic pH.

* Corresponding author. Mailing address: Laboratory of Food Microbiology, Wageningen University Agrotechnology and Food Sciences Group, P.O. Box 8129, 6700 EV Wageningen, The Netherlands. Phone: 31 317 484981. Fax: 31 317 484978. E-mail: tjakko.abee{at}wur.nl.

{dagger} Present address: TNO Defence, Security and Safety, Business Unit, Biological and Chemical Protection, P.O. Box 45, 2280 AA Rijswijk, The Netherlands.

Journal of Bacteriology, August 2006, p. 5650-5653, Vol. 188, No. 15
0021-9193/06/$08.00+0     doi:10.1128/JB.00323-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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