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Infection and Immunity, May 2006, p. 3042-3045, Vol. 74, No. 5
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.5.3042-3045.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

A Fungicidal Monoclonal Antibody Protects against Murine Invasive Candidiasis

María J. Sevilla,1* Beatriz Robledo,1 Aitor Rementeria,1 María D. Moragues,2 and José Pontón3

Departamento de Inmunología, Microbiología y Parasitología, Facultad de Ciencia y Tecnología,1 Facultad de Medicina y Odontología,3 Departamento de Enfermería I, Universidad del País Vasco, Apartado 644, E-48080 Bilbao, Vizcaya, Spain2

Received 2 November 2005/ Returned for modification 2 December 2005/ Accepted 9 February 2006

Mice infected by Candida albicans and treated with monoclonal antibody C7 survived longer than saline-treated animals. A prozone-like effect was observed. The in vitro candidacidal activity of macrophages was strongly enhanced when C. albicans was opsonized by C7 and complete murine serum was present.

* Corresponding author. Mailing address: Departamento de Inmunología, Microbiología y Parasitología, Facultad de Ciencia y Tecnología, Universidad del País Vasco, Apartado 644, E-48080 Bilbao, Vizcaya, Spain. Phone: 34-94-601-2688. Fax: 34-94-601-3500. E-mail: mariajesus.sevilla{at}ehu.es.

Editor: A. Casadevall

Infection and Immunity, May 2006, p. 3042-3045, Vol. 74, No. 5
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.5.3042-3045.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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Copyright © 2006 by the American Society for Microbiology. All rights reserved.