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Infection and Immunity, May 2006, p. 3035-3038, Vol. 74, No. 5
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.5.3035-3038.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Plasmodium falciparum Parasites Expressing Pregnancy-Specific Variant Surface Antigens Adhere Strongly to the Choriocarcinoma Cell Line BeWo

Rikke N. Haase,1 Rosette Megnekou,1 Maja Lundquist,1 Michael F. Ofori,1,2 Lars Hviid,1* and Trine Staalsoe1

Centre for Medical Parasitology, Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet) and Institute of Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark,1 Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana2

Received 2 January 2006/ Returned for modification 28 January 2006/ Accepted 1 February 2006

Placenta-sequestering Plasmodium falciparum parasites causing pregnancy-associated malaria express pregnancy-specific variant surface antigens (VSAPAM). We report here that VSAPAM-expressing patient isolates adhere strongly to the choriocarcinoma cell line BeWo and that the BeWo line can be used to efficiently select for VSAPAM expression in vitro.

* Corresponding author. Mailing address: Department of Infectious Diseases, M7641, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark. Phone: 45 35 45 79 57. Fax: 45 35 45 76 44. E-mail: lhcmp{at}rh.dk.

Editor: W. A. Petri, Jr.

Infection and Immunity, May 2006, p. 3035-3038, Vol. 74, No. 5
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.5.3035-3038.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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